学习与工作经历：

教育经历

(1) 1982-09 至 1987-07, 山东医科大学, 临床医学, 学士

(2) 1987-09 至 1990-07, 山东医科大学, 循环生理, 硕士

(3) 2000-09 至 2003-07, 中国协和医科大学, 神经生理, 博士

博士后工作经历

(1) 2004-01 至 2006-07, Dental school, University of Maryland, USA, Postdoctor

(2) 2006-08 至 2008-07,  School of Medicine, University of Pittsburgh, USA. Postdoctor.

科研与学术工作经历

(1) 2008-08 至 2014-01, School of Medicine, University of Pittsburgh, Research Associate 

(2) 2014-05--至今, 山东大学第二医院, 泌尿外科, 教授

研究方向：

生理及疾病状态下尿路（主要下尿路）感觉产生的外周神经机制。特别是膀胱过度活动症（OAB）、膀胱活动低下（UAB）、间质性膀胱炎膀胱疼痛综合征（IC/BPS）发生的外周感觉神经机制。具体研究内容为利用电生理、钙离子成像、组织学及分子生物学手段探讨多种TRP通道（TRPA1,TRPV1,TRPM3,TRPM7,TRPM8，TRPV2，TRPV4，TRPC等）,电压依赖性Na+、K+、Ca2+、Cl-通道及机械感受性Piezo1/2通道在UAB、OAB、间质性膀胱炎疼痛、神经源膀胱逼尿肌过度活动以及膀胱纤维化发生中的作用及细胞机制。

学术/社会兼职：

国际尿控协会（ICS）及美国疼痛学会会员。 

本科生课程：

研究生课程：

1. 81670686，老年特发性低活动膀胱（UAB）外周感觉神经机制的实验研究，国家自然科学基金面上项目，2017年01月至 2020年 12月，58.00万元，项目负责人。

2. 82070783，TRPM3通道参与IC/BPS慢性痛发生及机制的实验研究，国家自然科学基金面上项目，2021年01月至 2024年 12月，55.00万，项目负责人。

1. Zhao Mengmeng, Liu Lei, Chen Zhenghao, Ding Ning, Wen Jieliang, Liu Jiaxin, Ge Nan,Zhang Xiulin(corresponding).Upregulation of transient receptor potential cation channel subfamily M member-3 in bladder afferents is involved in chronic pain in cyclophosphamide-induced cystitis.Pain 2022，Feb 21. doi:10.1097/j.pain.0000000000002616. Online ahead of print.

2. Zhao MengMeng, Chen Zhenghao, Liu Lei, Ding Ning, Wen Jiliang, Liu Jiaxin, Wang WenZhen, Ge Nan, Zu Shulu, Song Wei, Chen Guoqing and Zhang Xiulin (corresponding).Functional Expression of Transient Receptor Potential and Piezo1 Channels in Cultured Interstitial Cells of Human-Bladder Lamina Propria. Frontiers in Physiology, 2021, 12:762847, doi: 10.3389/fphys.2021.762847

3. Jiliang Wen,Zhenghao Chen,Si Wang,Mengmeng Zhao,Shaoyong Wang,Shengtian Zhao,ZhangXiulin(corresponding).Age-related reductions in the excitability of phasic dorsal root ganglion neurons innervating the urinary bladder in female rats. Brain Res. 2021 Feb 1;1752:147251. doi: 10.1016/j.brainres.2020.147251

4. Jiliang Wen,Zhenghao Chen,Mengmeng Zhao,Shulu Zu,Shengtian Zhao,Shaoyong Wang,ZhangXiulin(corresponding).Cell Deformation at the Air-Liquid Interface Evokes Intracellular Ca 2+ Increase and ATP Release in Cultured Rat Urothelial Cells. Front Physiol. 2021 Feb 3;12:631022. doi: 10.3389/fphys.2021.631022.

5. Jiaxin Liu,Mengmeng Zhao,Zhenghao Chen,Yang Xu,Liqiang Guo,Shaoyong Wang,Yan Li,Benkang Shi,ZhangXiulin(corresponding),Xiao-Dong Jin.TRPM3 channel activation inhibits contraction of the isolated human ureter via CGRP released from sensory nerves.Life Sci . 2021 Mar 1;268:118967. doi: 10.1016/j.lfs.2020.118967.

6. Stephanie L Daugherty,Jonathan M Beckel,Kyoungeun A Kim,Bruce A Freeman,Jiaxin Liu,Shaoyong Wang,William C de Groat,ZhangXiulin(corresponding). TRP Channel Agonists Activate Different Afferent Neuromodulatory Mechanisms in Guinea Pig Urinary Bladder. Front Physiol . 2021 Jun 24;12:692719. doi: 10.3389/fphys.2021.692719.

7. Jiaxin Liu,Lei Liu,Mengmeng Zhao,Ning Ding,Nan Ge,Stephanie L Daugherty,Jonathan M Beckel,Shaoyong Wang,ZhangXiulin(corresponding). Activation of TRPM8 channel inhibits contraction of the isolated human ureter. Neurourol Urodyn. 2021 Aug;40(6):1450-1459. doi: 10.1002/nau.24689.

8. Zhang Xiulin, Hartung JE, Friedman RL, Koerber HR, Belfer I, Gold MS.Nicotine Evoked Currents in Human Primary Sensory Neurons.J Pain. 2019 Jul;20(7):810-818.doi: 10.1016/j.jpain.2019.01.005

9. Wen J, Zu S, Chen Z, Daugherty SL, de Groat WC, Liu Y, Yuan M, Cheng G,Zhang Xiulin(corresponding).Reduced bladder responses to capsaicin and GSK-1016790A in retired-breeder female rats with diminished volume sensitivity.Am J Physiol Renal Physiol, 2018 Nov 1;315(5):F1217-F1227.doi:10.1152/ajprenal.00198.2018

10. ZhangXiulin(corresponding),Jonathan M Beckel,Stephanie L Daugherty,Ting Wang,Stephen R Woodcock,Bruce A Freeman,William C de Groat.Activation of TRPC channels contributes to OA-NO2-induced responses in guinea-pig dorsal root ganglion neurons.J Physiol. 2014 Oct 1;592(19):4297-312. doi: 10.1113/jphysiol.2014.271783.

11. ZhangXiulin, Albers KM, Gold MS.Inflammation-induced increase in nicotinic acetylcholine receptor current in cutaneous nociceptive DRG neurons from the adult rat.Neuroscience. 2015 Jan 22;284:483-99.doi:10.1016/j.neuroscience.2014.10.018

12. Zhang Xiulin, Lee KY, Priest BT, Belfer I, Gold MS.Inflammatory mediator-induced modulation of GABAA currents in human sensory neurons.Neuroscience. 2015 Dec 3;310:401-409.doi:10.1016/j.neuroscience.2015.09.048

13. ZhangXiulin,Birgit T Priest,Inna Belfer,Michael S Gold.Voltage-gated Na+ currents in human dorsal root ganglion neurons.Elife . 2017 May 16;6:e23235. doi: 10.7554/eLife.23235.

14. Zhenghao Chen, Yaxiao Liu, Mengmeng Zhao, Shulu Zu, Yan Li, Benkang Shi, Shaoyong Wang ,Zhang Xiulin(corresponding). Urinary ATP may be a biomarker for bladder outlet obstruction and its severity in patients with benign prostatic hyperplasia.Transl Androl Urol 2020;9(2):284-294.doi:10.21037/tau.2020.02.18

15. Zhang Xiulin(corresponding), Koronowski KB, Li L, Freeman BA, Woodcock S, de Groat WC.Nitro-oleic acid desensitizes TRPA1 and TRPV1 agonist responses in adult rat DRG neurons.Exp Neurol,2014,251:12-21.doi: 10.1016/j.expneurol.2013.10.020

16. Zhang Xiulin(corresponding), Pietra C, Lovati E, de Groat WC.Activation of neurokinin-1 receptors increases the excitability of guinea pig dorsal root ganglion cells.J Pharmacol Exp Ther,2012,343(1):44-52.doi: 10.1124/jpet.112.196113

17. Zhang Xiulin(corresponding), Daugherty SL, de Groat WC.Activation of CaMKII and ERK1/2 contributes to the time-dependent potentiation of Ca2+ response elicited by repeated application of capsaicin in rat DRG neurons.Am J Physiol Regul Integr Comp Physiol,2011,300(3):R644-54.doi: 10.1152/ajpregu.00672.2010.Epub 2010 Dec 22.

18. Albers KM,Zhang XiulinDiges CM, Schwartz ES, Yang CI, Davis BM, Gold MS.Artemin growth factor increases nicotinic cholinergic receptor subunit expression and activity in nociceptive sensory neurons.Mol Pain,2014,10:31.doi: 10.1186/1744-8069-10-31

19. Zhu Y,Zhang Xiulin, Gold MS.Activity-dependent hyperpolarization of EGABA is absent in cutaneous DRG neurons from inflamed rats.Neuroscience, 2014,256:1-9.doi: 10.1016/j.neuroscience.2013.10.004

20. Zhang Xiulin, Mok LP, Lee KY, Charbonnet M, Gold MS.Inflammation-induced changes in BK(Ca) currents in cutaneous dorsal root ganglion neurons from the adult rat.Mol Pain,2012,8:37.doi: 10.1186/1744-8069-8-37

21. Lu SG,ZhangXiulin, Luo DZ, Gold MS.Persistent inflammation alters the density and distribution of voltage-activated calcium channels in subpopulations of rat cutaneous DRG neurons.Pain,2010,151(3):633-643,doi: 10.1016/j.pain.2010.08.030

22. Zhang Xiulin, Mok LP, Katz EJ, Gold MS.BKCa currents are enriched in a subpopulation of adult rat cutaneous nociceptive dorsal root ganglion neurons.Eur J Neurosci,2010,31(3):450-62,doi: 10.1111/j.1460-9568.2009.07060.x

23. Zhang Xiulin, Gold MS.Dihydropyridine block of voltage-dependent K+ currents in rat dorsal root ganglion neurons.Neuroscience,2009,161(1):184-94.doi: 10.1016/j.neuroscience.2009.03.012

24. Lu SG,Zhang Xiulin,Gold MS.Intracellular calcium regulation among subpopulations of rat dorsal root ganglion neurons.J Physiol,2006,577(Pt 1):169-90.doi:10.1113/jphysiol.2006.116418

25. Li CY,Zhang Xiulin, Matthews EA, Li KW, Kurwa A, Boroujerdi A, Gross J, Gold MS, Dickenson AH, Feng G, Luo ZD.Calcium channel alpha2delta1 subunit mediates spinal hyperexcitability in pain modulation.Pain, 2006,125(1-2):20-34. doi:10.1016/j.pain.2006.04.022