学习与工作经历：

1999-09~2004-06 青岛大学医学院 本科生

2004-09~2007-06 山东大学 硕士研究生

2005-08~2011-04 山东大学齐鲁医院 住院医师

2011-05~2018-08 山东大学齐鲁医院 主治医师

2012-08~2015-12 山东大学 博士

2018-09~2023-08 山东大学齐鲁医院 副主任医师

2019-02~2024-11 山东大学基础医学院 博士后

2020-11~2025-05 山东大学齐鲁医院 肝病科副主任（主持工作）

2022-11~2024-12 山东大学齐鲁医院 科研处副处长（兼）

2018-12~至今 山东大学齐鲁医院 硕士生导师

2021-09~至今 山东大学齐鲁医院 研究员

2022-05~至今 山东大学 临床教授

2023-01~至今 山东大学齐鲁医院（第一临床学院） 内科教研室（肝病）副主任

2023-09~至今 山东大学齐鲁医院 主任医师

2024-06~至今 山东大学齐鲁医院 博士生导师

2025-01~至今 山东大学齐鲁医院 供应处处长

2025-06~至今 山东大学齐鲁医院 肝病科主任

研究方向：

乙型肝炎的免疫机制，肝衰竭的预警预测研究

学术/社会兼职：

中华医学会医学病毒学分会常务委员

中国医师协会感染科医师分会常务委员

中华医学会感染病学分会青年委员

山东省医学会医学病毒学分会副主任委员

山东省医学会感染病学分会副主任委员

获奖荣誉：

山东省泰山学者青年专家

山东大学齐鲁医院杰出青年人才

本科生课程：

内科学

精准医疗与药物设计

检体诊断学

研究生课程：

1. 预测慢性肝病重症化的甲基化诊断试剂关键技术和产业化，国家重点研发计划“科技助力经济2020”重点专项，2020.08-2022.07，430万元，项目负责人

2. 81970522，DNA甲基化调控CD8+T细胞免疫反应在HBV感染中的作用和机制研究，国家自然科学基金面上项目，2020.01-2023.12，55万元，项目负责人

3. 82270631，FOXP3-TSDR甲基化调控Treg细胞在慢性HBV感染免疫耐受中的作用和分子机制，国家自然科学基金面上项目，2023.01-2026.12，52万元，项目负责人

4. 2022YFC2304500，益生菌及关键代谢物促进HBV特异性T细胞免疫清除的作用和分子机制，国家重点研发计划任务级课题，2022.12-2025.12，80万元，课题负责人

5. 2023YFF0718804，电子-声子耦合超宽带激光器在激光医学中的示范应用，国家国家重点研发计划子课题，2023.12-2026.11，75.5万元，课题负责人

6. 92463304，序构关键战略功能晶体研究，国家自然科学基金重大研究计划集成项目， 2025.01-2027.12，50万元，课题骨干

7. 2024CXGC010604，肿瘤靶向医用激光动力设备研制与应用，山东省重点研发计划（重大科技创新工程）子课题， 2024.09-2027.08，257.52万元，课题负责人

8. tsqn202103169,泰山学者青年专家经费，2021.03-2025.12，100万元，项目负责人

1. Wang T, Fan YC, Tan S, Wang Z, Li M, Guo X, Yu X, Lin Q, Song X, Xu L, Li L, Li S, Gao L, Liang X, Li C, Ma C. Probiotics and their metabolite spermidine enhance IFN-γ+CD4+ T cell immunity to inhibit hepatitis B virus. Cell Rep Med. 2024 Nov 19;5(11):101822.

2. Zhou S, Li M, Wang P, Guo C, Zhang J, Luo X, Fan YC, Chen EQ, Qi X, Chen J, Ye L, Yuan HY, Yin WB, Wang K, Zheng MH, Pang Y, Qiao J, Jiang C. A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite-CerS6-ceramide axis. Science. 2025 May;388(6746):eadp5540.

3. Ma HY, Yang XY, Tian YX, Li XD, He YL, Yang Q, Zheng MH, Zheng YB, Yu Y, Xu LY, Wang QN, Zhang T, Shi Y, Fan YC. Performance of the AASLD, EASL, and APASL Clinical Practice Guidelines in"grey zone"stages of Chinese patients with chronic hepatitis B. Hepatol Int. 2025;19(4):796-808.

4. You X, Hu X, Sun Z, Xu W, Liu L, Huang T, Yuan S, Yin J, Wang H, Wang L, Wang J, Xu W, Zhang Z, Zhang Y, Fan Y, Liu F. Dual targeting PPARα and NPC1L1 metabolic vulnerabilities blocks tumorigenesis. Cancer Lett. 2025 Mar 1:612:217493.

5. Wu YP, Feng J, Zhang YY, Wu BY, Zhao ZH, Fan YC. Biological ageing mediates the associations between urinary metals and metabolic dysfunction-associated steatotic liver disease. Ecotoxicol Environ Saf. 2025 Jul 15:300:118455.

6. Yang XY, Li XD, Wu BY, Yang Q, Zheng YB, Zheng MH, Wu YP, Ma HY, Zuo J, Jia RX, Yu Y, Xu LY, Tian YX, An Q, Zhang T, He YL, Shi Y, Fan YC. A Model to Identify Gray Zone Patients With Chronic Hepatitis B Requiring Antiviral Therapy: A Multicenter Retrospective Study. J Infect Dis. 2025;232(2):485-498.

7. Bao X, Li H, Wang Z, Tong F, Liu M, Zheng Z, Wang P, Cheng H, Liu Y, Dai Y, Fan YC, Li Z, Huang B. TiO2/Ti3C2 as an efficient photocatalyst for selective oxidation of benzyl alcohol to benzaldehyde. Appl Catal B: Environ, 2021,286,119885.

8. Lv M, He R, Li R, Zhang X, Xie W, Wang Z, Liu Y, Wang P, Cheng H, Fan YC, Huang B, Zheng Z. Dual-antenna@reactor with active “hot spots” for full-spectrum driven CO2 cycloaddition studied at single-particle level. Appl Catal B-Environ. 2025, 365, 124972.

9. Zhang M, Mao Y, Bao X, Zhai G, Xiao D, Liu D, Wang P, Cheng H, Liu Y, Zheng Z, Dai Y, Fan Y, Wang Z, Huang B. Coupling Benzylamine Oxidation with CO2 Photoconversion to Ethanol over a Black Phosphorus and Bismuth Tungstate S-Scheme Heterojunction. Angew Chem Int Ed Engl. 2023 Sep 4;62(36):e202302919.

10. Li W, Xiao D, Gong X, Xu X, Ma F, Wang Z, Wang P, Liu Y, Dai Y, Zheng Z, Fan YC, Huang B. Electrocatalytic upgrading of polyethylene terephthalate plastic to formic acid at an industrial-scale current density via Ni-MOF@MnCo-OH catalyst. Chem Eng J.2024,480,148087.

11. Lv M, Zhang X, Li B, Gong X, Zhang Y, Wang Z, Liu Y, Wang P, Cheng H, Dai Y, Fan YC, Huang B. Plasmonic Ag Interlayer Induced Direct Energy Transfer Studied at Single-Particle Level. ACS Energy Lett.2023,8(10):4033-4042.

12. Gong X, Zhang Y, Xu Y, Zhai G, Liu X, Bao X, Wang Z, Liu Y, Wang P, Cheng H, Fan Y, Dai Y, Zheng Z, Huang B. Synergistic Effect between CO2 Chemisorption Using Amino-Modified Carbon Nitride and Epoxide Activation by High-Energy Electrons for Plasmon-Assisted Synthesis of Cyclic Carbonates. ACS Appl Mater Interfaces. 2022 Nov 16;14(45):51029-51040.

13. Ma F, Wu Q, Liu M, Zheng L, Tong F, Wang Z, Wang P, Liu Y, Cheng H, Dai Y, Zheng Z, Fan Y, Huang B. Surface Fluorination Engineering of NiFe Prussian Blue Analogue Derivatives for Highly Efficient Oxygen Evolution Reaction. ACS Appl Mater Interfaces. 2021 Feb 3;13(4):5142-5152.

14. Bao X, Lv X, Wang Z, Wang M, Liu M, Dai D, Zheng L, Zheng Z, Cheng H, Wang P, Liu Y, Dai Y, Fan YC, Huang B. Nitrogen vacancy enhanced photocatalytic selective oxidation of benzyl alcohol in g-C3N4. Int J Hydrogen Energ. 2031,46(76),37782-37791.

15. Tian YX, Wu BY, An Q, Wu YP, Zuo J, Yeo YH, Fan YC. Global Prevalence, Temporal Trends, and Associated Mortality of Bacterial Infections in Patients with Liver Cirrhosis: A Meta-analysis. J Clin Transl Hepatol. 2025;13(11):918-934.

16. Wu YP, Yang XY, Tian YX, Feng J, Yeo YH, Ji FP, Zheng MH, Fan YC. Dose-dependent Relationship between Alcohol Consumption and the Risks of Hepatitis B Virus-associated Cirrhosis and Hepatocellular Carcinoma: A Meta-analysis and Systematic Review. J Clin Transl Hepatol. 2025;13(3):179-188.

17.Liu Y, Wang X, Xu F, et al. Risk Factors of Chronic Kidney Disease in Chronic Hepatitis B: A Hospital-based Case-control Study from China. J Clin Transl Hepatol. 2022;10(2):238-246.

18. Wu YP, Li FC, Ma HY, Yang XY, Zuo J, Tian YX, Lv L, Wang K, Fan YC. Characteristics and risk factors for invasive fungal infection in hospitalized patients with acute-on-chronic hepatitis B liver failure: a retrospective cohort study from 2010 to 2023. Front Microbiol. 2024;15:1391814.

19. Wang LY, Yang XY, Wu YP, Fan YC. IL-22-producing CD3 + CD8- T cells increase in immune clearance stage of chronic HBV infection and correlate with the response of Peg-interferon treatment. Clin Immunol. 2023;250:109320.

20.Wu BY, Tian YX, Zuo J, Yang JR, Fan YC. Global, Regional, and National Burdens of Hepatitis E From 1990 to 2021 and Predicted 2030 Incidence: Results From the Global Burden of Disease Study 2021. J Med Virol. 2025;97(3):e70279.

21.Zuo J, Tian YX, An Q, Wu BY, Yang JR, Fan YC. Potential Biomarkers and Therapeutic Targets in Hepatitis B Virus-related Acute Liver Failure: Interplay of the Ferroptosis, Autophagy and Immune Responses. Int J Med Sci. 2025;22(4):806-818.

22. Yang XQ, Yang XJ, Tian YX, An Q, Yao YX, Zuo J, Wu BY, Yang JR, Fan YC. Global, regional, and national burdens of cirrhosis in childhood and adolescence during 2000 to 2021: an age-period-cohort analysis. Front Public Health. 2025 Aug 29:13:1638207.

23. Zhao ZH, Fan YC. Editorial: High Baseline ALT Level Confers Risk of Hepatic Adverse Events During Immune Checkpoint Inhibitors Treatment: A Call for Caution. Aliment Pharmacol Ther. 2025 Feb;61(4):712-713.

24. Gong K, Xu X, Yao J, Ye S, Yu X, Tu H, Lan Y, Fan YC, Shi Y. Acute hepatitis of unknown origin in children: A combination of factors. Front Pharmacol. 2022;13:1056385.