学习与工作经历：

博士毕业于上海交通大学附属第六人民医院。后在山东大学齐鲁医院工作至今。先后于荷兰、新加坡、泰国、澳门等地学习人工髋膝关节置换及翻修的诊疗。

研究方向：

膝关节骨关节炎的分子机制研究以及人工智能抗菌性新材料研发。第一作者或通讯作者发表SCI文章十余篇，参与发表《Science》 2篇

学术/社会兼职：

《中华骨科杂志》特约审稿人

《中华肩肘外科电子杂志》工作站山东站编辑委员会委员

《中华创伤杂志》青年学术委员会委员

山东省医学会骨科分会关节外科学组委员

山东省研究型医院协会关节外科学分会肩关节学组组长

山东省公共卫生学会骨关节分会副主任委员

山东省医学会骨科分会关节外科学组人工智能工作委员会委员

山东省医师协会创新与转化医学专业委员会委员

中国康复医学会修复重建外科专业委员会骨缺损骨坏死学组委员

中国老年保健协会骨关节保护与健康分会委员 

获奖荣誉：

2019年山东大学临床医学院教学成果一等奖

本科生课程：

《手术学》，《外科学》骨科（关节部分）

研究生课程：

260101120025CG 神经酰胺-GPCR信号轴调控骨再生的分子机制及靶向干预策略研究  横向课题  2025.10-2028.03    75万  主持

26010112002420  地舒单抗促进骨质疏松症患者髋关节置换术后假体周围骨密度的研究  横向课题 2023.11-2026.8  10万 主持

82272548  GDF11通过TNF-α/NF-κB/GPX4分子轴线调控髓核细胞铁死亡延缓椎间盘退变的机制研究  国家自然基金 2023.1-2026.12  参与

1) Lin H, Ma C, Cai K, et al. Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis. Science 13: eado4188[EB/OL].(2025)

2) Wang S, Zhou X, Zhang F, et al. Thrombospondin-1 mitigates osteoarthritis progression by inhibiting mechanical stress-induced chondrocyte ferroptosis via the integrin/YAP pathway[J]. Frontiers in Immunology, 2025, 16: 1577234.

3) Zhang H, Wang Z, Li Q, et al. IRTKS promotes osteogenic differentiation by inhibiting PTEN phosphorylation[J]. Biomedicine & Pharmacotherapy, 2024, 177: 116872.

4) Unsaturated bond recognition leads to biased signal in a fatty acid receptor[J]. Science, 2023, 380(6640): eadd6220.

5) He Q, Zhang H, Hu B, et al. CircRNA hsa_circ_0001421 promotes the osteoblast differentiation of human adipose mesenchymal stem cells through the miR-608/SP7 axis[J]. Biochemical Engineering Journal, 2022, 181: 108386.

6) He Q, Li R, Hu B, Guo Y. Stromal cell-derived factor-1 promotes osteoblastic differentiation of human bone marrow mesenchymal stem cells via the lncRNA-H19/miR-214-5p/BMP2 axis[J]. J Gene Med, 23(9) (2021) e3366.

7) Guo Y-Y, Liu B, Hu B-B, Xiao G-Y, Wu Y-P, Sun P-F, et al. Antibacterial activity and increased osteoblast cell functions of zinc calcium phosphate chemical conversion on titanium. Surface and Coatings Technology. 2016;294:131-8.

8) Guo Y, Hu B, Tang C, Wu Y, Sun P, Zhang X, et al. Increased osteoblast function in vitro and in vivo through surface nanostructuring by ultrasonic shot peening. Int J Nanomedicine. 2015;10:4593-603.

9) Wang ZP, Zhang HF, Zhang F, Hu BL, Wei HT, Guo YY. Bevacizumab did not reduce the risk of anemia associated with chemotherapy: an up-to-date meta-analysis. European journal of clinical pharmacology. 2015;71:517-24.

10) GUO Y-y, CHENG M-q, CHEN D-s, XUE X-b, ZHANG X-l. In vitro corrosion resistance and cytotoxicity of novel TiNbTaZr alloy. T Nonferr Metal Soc (Eng). 2012;22:s175–s80.（SCI 1.178，第一作者）

11) Guo Y, Chen D, Lu W, Jia Y, Wang L, Zhang X. Corrosion resistance and in vitro response of a novel Ti35Nb2Ta3Zr alloy with a low Young's modulus. Biomedical materials (Bristol, England). 2013;8:055004.

12) Guo Y, Chen D, Cheng M, Lu W, Wang L, Zhang X. The bone tissue compatibility of a new Ti35Nb2Ta3Zr alloy with a low Young's modulus. International journal of molecular medicine. 2013;31:689-97.

13) Cheng T, Zhu C, Guo Y, Shi S, Chen D, Zhang X. Patellar denervation with electrocautery in total knee arthroplasty without patellar resurfacing: a meta-analysis. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA. 2014;22:2648-54.

14) Zhu C, Tan H, Cheng T, Shen H, Shao J, Guo Y, et al. Human beta-defensin 3 inhibits antibiotic-resistant Staphylococcus biofilm formation. The Journal of surgical research. 2013;183:204-13.

15) Zhu C, He N, Cheng T, Tan H, Guo Y, Chen D, et al. Ultrasound-targeted microbubble destruction enhances human beta-defensin 3 activity against antibiotic-resistant Staphylococcus biofilms. Inflammation. 2013;36:983-96.

16) Cheng T, Chen D, Zhu C, Pan X, Mao X, Guo Y, et al. Fixed- versus mobile-bearing unicondylar knee arthroplasty: are failure modes different? Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA. 2013;21:2433-41.

17) Cheng M, Chen D, Guo Y, Zhu C, Zhang X. Comparison of fixed- and mobile-bearing total knee arthroplasty with a mean five-year follow-up: A meta-analysis. Experimental and therapeutic medicine. 2013;6:45-51.

18) Chen D, Zhang X, Guo Y, Shi S, Mao X, Pan X, et al. MMP-9 inhibition suppresses wear debris-induced inflammatory osteolysis through downregulation of RANK/RANKL in a murine osteolysis model. International journal of molecular medicine. 2012;30:1417-23.

19) Chen D, Guo Y, Mao X, Zhang X. Inhibition of p38 mitogen-activated protein kinase down-regulates the inflammatory osteolysis response to titanium particles in a murine osteolysis model. Inflammation. 2012;35:1798-806.