学习与工作经历：

学习经历

1992.09-1997.07   潍坊医学院临床医学系本科

1997.09-1999.07   山东大学（原山东医科大学）骨科硕士研究生

1999.09-2002.07   山东大学骨科博士研究生

2007.04-2008.03   Nippon Medical School（日本医科大学整形外科）

2011.08-2011.11  Hartford Hospital(USA)

2014.04-2014.11  RUSH university medical center

工作经历

2002.07-2007.03  山东大学齐鲁医院骨科主治医师

2008.03-2015.09  山东大学齐鲁医院骨科副教授，硕士生导师

2015.09-2016.10 山东大学齐鲁医院骨科主任医师，硕士生导师

2016.10-2017.03 山东大学齐鲁医院骨科主任医师，博士生导师

2017.03-2019.05  山东大学齐鲁医院骨科主任医师，博士生导师（专业型），脊柱外科副主任

2019.05-2020.12   山东大学齐鲁医院骨科主任医师，博士生导师（学术型），脊柱外科副主任

2020.12-2021.11 山东大学齐鲁医院骨科主任医师，博士生导师（学术型），骨科常务副主任，脊柱外科副主任

2021.11-至今   山东大学齐鲁医院骨科主任医师，博士生导师（学术型），骨科常务副主任，脊柱外科主任，骨科一病区主任

研究方向：

主要从事脊柱退变性疾病的微创手术治疗、脊柱畸形矫形手术治疗等相关临床及科研工作。

学术/社会兼职：

中华医学会骨科学分会微创外科学组委员，SICOT中国部常委、SICOT中国部微创外科学会副主任委员，中华预防医学会脊柱疾病预防与控制专委会脊柱退变学组委员，中华中医药学会脊柱微创专委会常委，山东省医学会骨科学分会候任主委、微创学组副组长，国际神经修复学会理事，腰椎侧方入路学会中国部委员，中国康复医学会脊柱脊髓专业委员会青年委员及脊柱脊髓基础学组委员，中国老年学及老年医学学会老年骨科专委会委员及脊柱学组委员；山东省疼痛医学会骨科分会副主任委员等。

获奖荣誉：

山东省科技进步二等奖1项、山东医学科技二等奖1项、山东医学科技三等奖2项、天津市科学技术特等奖1项，实用新型专利4项。

本科生课程：

《外科学》、《3D打印技术及材料学进展》、《人工智能及数字化学科交叉课程》

研究生课程：

《骨科相关研究进展》、《骨科学诊疗技术进展》、《脊柱微创技术相关研究进展》

1. 81272024  Decorin 基因转染调控 TGF-beta/Smad 抑制腰椎黄韧带增生的实验研究 国家自然科学基金委 2013年01月-2016年12月  75万元 项目负责人

2. 81874022  Circ_010567-miRNA141靶向调控TGF-β1-ALK1/5双通路对黄韧带细胞外基质重塑的影响及机制研究 国家自然科学基金委  2019年01月-2022年12月  57万元  项目负责人

3. 82172483温敏水凝胶缓释HBMSC-exo介导circRNA_0069313-miR_142-3p-TGF-β1调控腰椎黄韧带肥厚的研究 国家自然科学基金委 2022年01月-2025年12月  55万元  项目负责人 

4. 2022CXGCO10503 微创脊柱外科远程手术机器人研发及产业化示范应用  山东省科技厅 2022年1月-2025年1月 120万元 课题负责人

1.Yang X, Wang L, Yang Q, Su J, Qiu C, Ibrahim Y, Yuan S, Tian Y, Liu X. Neurological Safety of Endoscopic Transforaminal Lumbar Interbody Fusion: A Magnetic Resonance Neurography Study. Spine (Phila Pa 1976). 2022 Sep 28. doi: 10.1097/BRS.0000000000004496. Epub ahead of print. PMID: 36191017.

2.Wang L, Li C, Wang Z, Li D, Tian Y, Yuan S, Liu X. Comparison of robot-assisted versus fluoroscopy-assisted minimally invasive transforaminal lumbar interbody fusion for degenerative lumbar spinal diseases: 2-year follow-up. J Robot Surg. 2022 Jul 5. doi: 10.1007/s11701-022-01442-5.

3.Jia J, Chen C, Wang P, Wang L, Liu X. Comparison of Adjacent Segment Degeneration After Minimally Invasive or Open Transforaminal Lumbar Interbody Fusion: A Minimum 5-Year Follow-up. Clin Spine Surg. 2022 Jun 8. doi: 10.1097/BSD.0000000000001351.

4.Wang L, Li C, Wang L, Qi L, Liu X. Sciatica-Related Spinal Imbalance in Lumbar Disc Herniation Patients: Radiological Characteristics and Recovery Following Endoscopic Discectomy. J Pain Res. 2022 Jan 6;15:13-22. doi: 10.2147/JPR.S341317.

5.Chang MZ., Wang LL., Yuan SM., Tian YH., Zhao YW., Liu Xinyu.(2022). Percutaneous Endoscopic Robot-Assisted Transforaminal Lumbar Interbody Fusion (PE RA-TLIF) for Lumbar Spondylolisthesis: A Technical Note and Two Years Clinical Results. Pain Physician, 2022,25(1), E73-E86.

6.Ibrahim Y, Li H, Zhao G, Yuan S, Zhao Y, Liu W, Tian Y, Wang L, Liu X. Posterior Temporary C1-2 Pedicle Screws Fixation for the Treatment of Unstable C1-2 Complex Fractures: Minimum of 2-Year Follow-Up. Global Spine J. 2021 Aug 19:21925682211039186. doi: 10.1177/21925682211039186.

7.Wang Lianlei., Li Hao., Zhao Yiwei., Yuan Suomao., Tian Yonghao., Liu Xinyu.(2021). Ligamentum-preserved/temporary preserved minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) for lumbar spondylolisthesis: technical note and two-years follow-up. Spine (Phila Pa 1976), undefined(undefined), undefined. doi:10.1097/BRS.0000000000004136

8.Wang L, Chang M, Tian Y, Yan J, Xu W, Yuan S, Zhang K, Liu X. The Role of Smad2 in Transforming Growth Factor β1-Induced Hypertrophy of Ligamentum Flavum. World Neurosurg. 2021 Apr 5:S1878-8750(21)00518-0. doi: 10.1016/j.wneu.2021.03.147.

9.Zhao Y, Yuan S, Liu W, Tian Y, Liu X. Clinical Validity of 3 Different Grading Systems for Facet Joint Violation: A Retrospective Study and In-Depth Review. Global Spine J. 2021 Apr 20:21925682211006028. doi: 10.1177/21925682211006028.

10.Zhao Y, Yuan S, Tian Y, Wang L, Liu X. Uniplanar Cannulated Pedicle Screws in the Correction of Lenke Type 1 Adolescent Idiopathic Scoliosis. World Neurosurg. 2021 Jan 30:S1878-8750(21)00130-3. doi: 10.1016/j.wneu.2021.01.099.

11.Chen X, Yang Q, Kalisi KUMM, Yuan S, Tian Y, Liu X. Comparison of Morphometric Measurements of Traditional Posterior Cervical Screw and Paravertebral Foramen Screw in Chinese Population. Spine (Phila Pa 1976). 2021 Apr 1;46(7):E443-E449. doi: 10.1097/BRS.0000000000003807.

12.Yakubu Ibrahim, Yiwei Zhao, Wubo Liu, Suomao Yuan, Yonghao Tian, Lianlei Wang, Xinyu Liu. An unusual injury mechanism of atlantoaxial dislocation: illustrative case. J Neurosurg Case Lessons 1(24):CASE21134, 2021 DOI: 10.3171/CASE21134

13.Liu W, Zhao Y, Yuan S, Tian Y, Liu X. Modified mini-open SRS-Schwab grade 4 osteotomy combined with percutaneous pedicle screws fixation in post-traumatic thoracolumbar kyphosis. BMC Musculoskelet Disord. 2020 Sep 28;21(1):638-645. doi: 10.1186/s12891-020-03666-8.

14.Zhao Y, Yuan S, Tian Y, Liu X. Necessity of routinely performing foraminoplasty during percutaneous endoscopic transforaminal discectomy (PETD) for lumbar disc herniation. Br J Neurosurg. 2020 Sep 11:1-7. doi: 10.1080/02688697.2020.1817853.

15.Liu W, Zhao Y, Jia J, et al. Morphologic changes of intervertebral foramen after minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF): a radiographic and clinical study [published online ahead of print, 2020 Jun 26]. World Neurosurg. 2020;S1878-8750(20)31411-X.

16.Mai, R., Tan, H., Zhao, Y. et al. Diagnostic value and clinical significance of magnetic resonance imaging with the FS-PD-TSE sequence in diagnosing lumbar cartilaginous endplate failure. Eur Spine J 29, 1121–1130 (2020).https://doi.org/10.1007/s00586-020-06338-2

17.Zhao Y, Yuan S, Tian Y, Liu X. Risk Factors Related to Superior Facet Joint Violation During Lumbar Percutaneous Pedicle Screw Placement in Minimally Invasive Transforaminal Lumbar Interbody Fusion (MIS-TLIF) [published online ahead of print, 2020 Apr 28]. World Neurosurg. 2020;S1878-8750(20)30825-1. doi:10.1016/j.wneu.2020.04.118

18.Zhao Y, Jia J, Liu W, Chen X, Mai R, Tian Y, Zhao J, Liu X. Influence of contoured versus straight rod on clinical outcomes and sagittal parameters in minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) at L4/5 level-more than 5 years follow-up. J Orthop Sci. 2020 Jan;25(1):89-95. doi: 10.1016/j.jos.2019.03.008. [Epub ahead of print]PubMed PMID: 30929967.

19.Xinyu Yang, Xinyu Liu. Instrumentation-related complications of lumbar degenerative disc diseases treated by minimally invasive transforaminal lumbar interbody fusion Brain Science Advances 2019, 5(3): 213–219 https://doi.org/10.26599/BSA.2019.9050019

20.Bing Fu, Yonghao Tian, Xinyu Liu. Treatment of single-segment lumbar tuberculosis with minimally invasive posterior internal fixation combined with anterior small incision debridement. Brain Science Advances 2019, 5(3): 203–212.

21.Jia J, Zhao Y, Liu X. Impact of sagittal imbalance correction on clinical outcomes in patients undergoing MIS-TLIF for LSS. Clin Neurol Neurosurg. 2019 Jun;181:119-126. doi: 10.1016/j.clineuro.2019.04.017. Epub 2019 Apr 15. PubMed PMID: 31039493.

22.Yuan S, Wei B, Tian Y, Yan J, Xu W, Wang L, Liu X. Posterior temporary C1-2 fixation for 3-part fractures of the axis (odontoid dens and Hangman fractures). Medicine (Baltimore). 2018 Nov;97(48):e12957. doi: 10.1097/MD.0000000000012957. IF 1.803

23.Liu X, Yuan S, Tian Y, Wang L, Gong L, Zheng Y, Li J. Comparison of percutaneous endoscopic transforaminal discectomy, microendoscopic discectomy, and microdiscectomy for symptomatic lumbar disc herniation: minimum 2-year follow-up results. J Neurosurg Spine. 2018,28(3) 317-325. doi: 10.3171/2017.6.SPINE172. IF 2.696

24.Yuan S, Wei B, Tian Y, Yan J, Xu W, Wang L, Liu X. The comparison of clinical outcome of fresh type II odontoid fracture treatment between anterior cannulated screws fixation and posterior instrumentation of C1-2 without fusion: a retrospective cohort study. J Orthop Surg Res. 2018 Jan 8;13(1):3. doi:10.1186/s13018-017-0702-0. IF 1.545

25.Tian Y, Liu X. Clinical outcomes of two minimally invasive transforaminal lumbar interbody fusion (TLIF) for lumbar degenerative diseases. Eur J Orthop Surg Traumatol. 2016 Oct;26(7):745-51. doi: 10.1007/s00590-016-1755-1. Epub 2016 Mar 4.

26.Wang L, Liu X. Cervical sagittal alignment in adolescent idiopathic scoliosis patients (Lenke type 1-6). J Orthop Sci. 2016 Dec 23. pii: S0949-2658(16)30247-0. doi: 10.1016/j.jos.2016.12.006. [Epub ahead of print](IF 1.133)

Wang L, Liu X. Cervical sagittal alignment in adolescent idiopathic scoliosis patients (Lenke type 1-6) [J]. Journal of Orthopaedic Science, 2017, 22(2):254. IF 1.133

27.Liu Xinyu, Wang lianlei, Yuan Suomao, Tian Yonghao, Zheng Yanping, Li Jianmin. Multiple-level Lumbar Spondylolysis and Spondylolisthesis. J Neurosurg Spine. 2015 Mar; 22(3): 283-7, DOI: 10.3171/2014.10.SPINE14415. IF 2.696

28.Xinyu Liu, Suomao Yuan, Yonghao Tian, Lianlei Wang, Yanping Zheng, Jianmin Li. Expanded eggshell procedure combined with closing-opening technique (a modified vertebral column resection) for the treatment of thoracic and thoracolumbar angular kyphosis. J Neurosurg Spine. 2015 Jul;23(1):42-8http:// thejns.org/doi/abs/ 10.3171/2014.11.SPINE14710. IF 2.696

29.Liu Xinyu; Yuan, Suomao; Tian, Yonghao.Modified Unilateral Laminotomy for Bilateral Decompression for Lumbar Spinal Stenosis: Technical Note. Spine, 2013, 38(12): E732-E737, May 20, 2013.

30.Liu Xinyu, Zhang Kai，Gong Laing-tai，Zheng Yan-ping, Li Jian-min. The anatomic and radiographic measurement of C2 lamina in Chinese population.Eur Spine J.2011 Dec; 20(12): 2261-6. IF-1.965

31.Liu X,Wang Y,Wu X,Zheng Y,Jia L,Li J,Zhang K,Li J,Wei B. Impact of surgical approaches on the lumbar multifidus muscle: an experimental study using sheep as models. JNeurosurg Spine2010; 12(5): 570-6.

32.Liu Xinyu, Konno S, Miyamoto M, Gembun Y, Horiguchi G, Ito H.Clinical usefulness of assessing lumbar somatosensory evoked potentials in lumbar spinal stenosis.J Neurosurg Spine 2009,11(1):71-78.

33.Liu Xinyu, Konno S, Miyamoto M, Gembun Y, Horiguchi G, Ito H.Clinical value of motor evoked potentials with transcranial magnetic stimulation in the assessment of lumbar spinal stenosis. International Orthopaedics 2009 33 (4),1069-1074.

34.Liu Xinyu,Yanping Z, Jianmin L, Liangtai G. Hemilaminoplasty for the treatment of lumbar disc herniation. International Orthopaedics 2009，33(5):1323-1327.