学习与工作经历：

2016.8-至今    山东大学齐鲁医院泌尿外科

2014.10-2015.12 美国耶鲁大学联合培养博士

2013.9-2016.6   复旦大学外科学（泌尿外科方向）博士

2006.9-2013.7   山东大学临床医学（本硕连读7年制）

研究方向：

膀胱免疫微环境与膀胱功能障碍

泌尿系统医工结合研究

学术/社会兼职：

国际尿控协会（ICS）会员

韩国泌尿外科协会（KUA）国际会员

中国医师协会中西医结合分会泌尿外科青年委员会副主任委员

中国老年保健协会盆底医学分会青年委员会副主任委员

中国医师协会泌尿外科分会青年委员

中国研究型医院协会泌尿外科委员会青年委员

中华医学会泌尿外科委员会尿控学组委员

中华医学会泌尿外科青委会转化医学学组委员

获奖荣誉：

2021年  山东省医学科技奖二等奖（第2位）

2020年  山东大学齐鲁医院杰出青年人才

2019年  中华医学会尿控年会优秀论文三等奖

2018年  中国中青年泌尿外科医师临床技能大赛三等奖

2018年  亚洲泌尿外科青年医师大赛第二名（Second Prize）

2018年  中国医师协会中西医结合分会泌尿外科年会优秀论文二等奖

本科生课程：

《外科学》《智能医学》

研究生课程：

1、2022JC004 高密度柔性可拉伸干电极阵列研发与应用验证，山东大学集成攻关培育项目 2022.7-2024.7 120万元 主持

2、CRCC021,骶神经调控术对脊髓损伤患者神经源性膀胱功能障碍的疗效研究，山东大学临床研究项目， 2020-07至2023-06, 20万元, 主持

3、81900637, 膀胱上皮细胞来源外泌体microRNA调控骨髓来源抑制性细胞（MDSC）影响膀胱细菌感染结局的机制研究,国家自然科学基金委员会青年项目, 2020-01至2022-12, 20万元,主持

4、81970661, 膀胱上皮细胞来源外泌体LncRNA MALAT1通过NLRP3炎症小体调控BOO后膀胱重塑的机制探究,国家自然科学基金委员会面上项目, 2020-01至2023-12, 53万元, 参加。

5、320.6750.19092-21，基于基因突变谱的膀胱癌复发风险预测模型的建立，吴阶平医学基金会临床科研专项基金，2020-01至2022-12,10万元, 主持

6、2018WS333，膀胱上皮细胞GM-CSF对细菌感染后膀胱局部免疫应答的调控机制研究，山东省医药卫生科技发展计划项目， 2019/01-2021/12，主持

1. Gao Zhengdong., Liu Yaxiao., Zhang Lekai., Yang Zizhuo., Lv Linchen., Wang Shuai., Chen Lipeng., Zhou Nan., Zhu Yaofeng., Jiang Xuewen., Shi Benkang.,Li Yan. Escherichia coliNociceptor Neurons are Involved in the Host Response to Urinary Tract Infections. [J] Journal of Inflammation Research 2022, 15: 3337-3353.

2. Chen Lipeng., Lv Linchen., Zhang Lekai., Gao Zhengdong., Liu Yaxiao., Wang Shuai., Zhou Nan., Xia Yangyang., Cui Jianfeng., Jiang Xuewen., Zhang Xiulin.,Li Yan., Shi Benkang.(2021). Metformin ameliorates bladder dysfunction in a rat model of partial bladder outlet obstruction. Am J Physiol Renal Physiol,2021,320(5), F838-F858.

3.Li Yan,Liu Y, Gao Z, Zhang L, Chen L, Wu Z, Liu Q, Wang S, Zhou N, Chai TC, Shi B.Single-cell transcriptomes of mouse bladder urothelium uncover novel cell type markers and urothelial differentiation characteristics. Cell Proliferation 2021 DOI:10.1111/cpr.13007

4.Wu Z, Zhu K, Liu Q, Liu Y, Chen L, Cui J, Guo H, Zhou N, Zhu Y,Li Yan,Shi B,Profiles of Immune Infiltration in Bladder Cancer and its Clinical Significance: an Integrative Genomic Analysis.Int J Med Sci 2020;17(6)

5. Wu Z, Wang M, Liu Q, Liu Y, Zhu K, Chen L, Guo H,Li Yan*, Shi B*. Identification of gene expression profiles and immune cell infiltration signatures between low and high tumor mutation burden groups in bladder cancer. Int J Med Sci. 2020 Jan 1;17(1):89-96.

6. Wu Z, Liu Q, Zhu K, Liu Y, Chen L, Guo H, Zhou N,Li Yan*, Shi B*. Cigarette smoke induces the pyroptosis of urothelial cells through ROS/NLRP3/caspase-1 signaling pathway. Neurourol Urodyn. 2020 Feb;39(2):613-624.

7. Liu Q, Wu Z, Liu Y, Chen L, Zhao H, Guo H, Zhu K, Wang W, Chen S, Zhou N,Li Yan*, Shi B*. Cannabinoid receptor 2 activation decreases severity of cyclophosphamide-induced cystitis via regulating autophagy. Neurourol Urodyn. 2020 Jan;39(1):158-169.

8. Wu Zonglong^#,Li Yan^#,Liu Qinggang, Liu Yanxiao, Chen Lipeng, Zhao Hongda, Guo Hongda, Zhu Kejia, Zhou Nan, Chai Toby, Shi Benkang. Pyroptosis engagement and bladder urothelial cells derived exosomes recruit mast cells and induce barrier dysfunction of bladder urothelium after UPEC infection. American Journal of Physiology-Cell Physiology. 2019,DOI：10.1152/ajpcell.00102.

9. Liu, Yaxiao^#,Li Yan^#,Liu Qinggang, Wu Zonglong, Cui Jianfeng, Zhu Kejia, Zhao Hongda, Zhou changkuo, Shi Benkang. The role of GM-CSF in a mouse model of experimental autoimmune prostatitis. American Journal of Physiology-Renal Physiology. 2019;317(7):F23-F29.

10. Xu Xufeng^#, Wang Youcui, Zong Liang, Chen Zhiyu,Li Yan*. Elevating Integrin-linked Kinase expression has rescued hippocampal neurogenesis and memory deficits in an AD animal model,Brain Res. 2018 Sep 15;1695:65-77.

11.Li Yan^#, Lu Ming, Alvarez-Lugo Lery, Chen Gang, Chai Toby*. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is released by female mouse bladder urothelial cells and expressed by the urothelium as an early response to lipopolysaccharides (LPS), Neurourology and Urodynamics, 2017, 36(4): 1020-1025.

12. Wu Zhiming^#,Li Yan^#, Li Zhiyong, Liu Zhuowei, Qin Zike, Li Xiangdong, Ye Yunlin, Bu Lei, Lin Bin, Wang Zhanyu, Jia Guojin, Chen Gang*. Transcriptional regulation of E-cadherin by small activating RNA: A new double-stranded RNA, International Journal of Oncology, 2016, 49(4): 1620-8.

13.Li Yan^#, Xu Guofeng, Huang Kai, Wang Jun, Zhang Jihong, Liu Jikai, Wang Zhanyu, Chen Gang*. Alteration of ASIC1 expression in clear cell renal cell carcinoma, OncoTargets and Therapy, 2015, 14(8): 2121-7.

14.Li Yan^#, Li Shun^#, Zhu Yaofeng, Liang Xinyue, Meng Hui, Chen Jun, Zhang Deqing, Guo Hu, Shi Benkang*. Incidence and risk of hypertension with sorafenib in patients with cancer: a meta-analysis, Journal of Clinical Hypertension. 2014, 16(3): 177-85.

15.Li Yan^#, Sun Yan^#, Zhang Zhaocun, Feng Xiaodi, Meng Hui, Li Shun, Zhu Yaofeng, Chen Shouzhen, Wang Yang, Wang Jun, Zhang Deqing, Jiang Xuewen, Li Ning, Shi Benkang*. Cannabinoid receptors 1 and 2 are associated with bladder dysfunction in an experimental diabetic rat model, BJU International, 2013, 112(2): E143-150.