学习与工作经历：

2001年至今 肝病科创建人、学科带头人

2009.06至今 山东大学肝病研究所所长

2006.06至今 山东大学博士生导师

2002.09至今 山东大学齐鲁医院主任医师、教授

2001.04至今 山东大学齐鲁医院内科副主任

2004.05-2019.07 山东大学齐鲁医院肝病科主任

2004.12-2006.12  中国疾病预防控制中心 博士后

2001.09-2004.06   山东大学   博士研究生毕业，医学博士学位

2001.04-2004.05 山东大学齐鲁医院肝病科副主任

1997.01-2002.09山东大学齐鲁医院副主任医师、副教授

1985.06-1996.12山东医科大学附属医院住院医师、主治医师

1983.07-1985.06 山东省立医院住院医师

研究方向：

（1）肝病表观遗传分子分型和个体化诊断：建立了DNA甲基化分子标志物为基础的肝衰竭诊断标准和评估体系；

（2）肝病免疫细胞调控的基础和临床研究：系统开展慢性乙型肝炎的免疫研究，以Th17细胞、Th22细胞以及CTL细胞为重点，着眼于建立乙型肝炎表面抗原转阴的临床预警分子标志物，研究成果达到国际领先水平；

（3）氧化损伤在肝病中的基础和临床研究：通过临床流行病学方法和生物化学方法相结合，发现慢性乙型肝炎患者存在氧化损伤平衡状态紊乱，提出抗氧化损伤可能有助于慢性乙型肝炎患者高胆红素血症的治疗，应用于临床治疗，取得较好的临床效果；

（4）HBsAg转阴研究；

（5）肝硬化的综合治疗的研究；

（6）肝癌的早期诊断和综合治疗的研究；

（7）药食同源产品研发，多项科技成果转化，在企业落地投产。

学术/社会兼职：

国家感染性疾病临床医学研究中心山东省分中心负责人，国家卫生计生委合理用药专家委员会抗菌药物专业组专家，中华医学会医学病毒学分会委员，中国医师协会感染科医师分会常务委员，中国微生物学会干扰素与细胞因子专业委员会副主任委员，中国研究型医院学会感染病学专业委员会常务委员，山东省医学会医学病毒学分会主任委员，山东省医药教育协会感染病专业委员会主任委员，山东省医学会感染病学分会名誉主任委员，山东省医师协会感染科医师分会名誉主任委员，山东省流行病传染病防控和应急处置中医药专家委员会成员

获奖荣誉：

第十届吴阶平医学研究奖-保罗•杨森药学研究奖三等奖

山东省科技进步奖二等奖2项（第一完成人）

本科生课程：

《内科学》肝脏疾病部分

研究生课程：

1. 2017ZX10202202-001-007，提高HBeAg阳性慢乙肝临床治愈率新方案的研究，中华人民共和国科学技术部，2017.01-2020.12，70.17万元，主持；

2. 2017ZX10202202-002-007，提高HBeAg阴性慢乙肝临床治愈率新方案的研究，中华人民共和国科学技术部，2017.01-2020.12，58.09万元，主持；

3. 2021YFC2301801，细胞因子风暴综合征的临床特征及疾病重症化的预警预测研究，中华人民共和国科学技术部，2021.12-2024.11，77.64万元，主持；

4. 82272313，乙型肝炎病毒调控DNA甲基化诱导T淋巴细胞亚群失衡的机制研究，国家自然基金项目，2022.09-2026.12，52万元，主持；

(1)Wang H, Yin YP, Wang ZL, Qian Y, Fan YC, Liu HH, Wang K.Hypermethylation of thymosin β4 predicts a poor prognosis for patients with acute-on-chronic hepatitis B liver failure.Hepatobiliary Pancreat Dis Int.2022;S1499-3872(22)00191-6.

(2)Liu HH, Wang J, Zhang Y, Fan YC, Wang K.Prognostic potential of the small GTPase Ran and its methylation in hepatocellular carcinoma.Hepatobiliary Pancreat Dis Int. 2022;21(3):248-256.

(3)Yang JR, Wang J, Li HM, Gao S, Fan YC, Wang K.IL-6 Promoter Hypomethylation Acts As a Diagnostic Biomarker in Hepatitis B Virus-Associated Hepatocellular Carcinoma.

Front Oncol.2022;12:746643.

(4)Wang H, Qian Y, Wang JW, Fang Y, Fan YC, Liu HH, Wang K.Hypomethylation of thymosin β4 promoter is associated with glucocorticoid therapy in patients with acute-on-chronic hepatitis B-induced liver failure.Int Health. 2022;ihac003.

(5)Ji XF, Fan YC, Sun F, Wang JW, Wang K.Noncanonical Wnt5a/JNK Signaling Contributes to the Development of D-Gal/LPS-Induced Acute Liver Failure.Inflammation. 2022;45(3):1362-1373.

(6)Qian Y, Wang H, Zhang Y, Wang JW, Fan YC, Gao S, Wang K. Hypermethylation of Cyclin D2 Predicts Poor Prognosis of Hepatitis B Virus-Associated Hepatocellular Carcinoma after Hepatectomy. Tohoku J Exp Med.2021;254(3):233-243.

(7)Gao S, Fan YC, Han LY, Wang K. Serum exosomal long noncoding RNA nuclear-enriched abundant transcript 1 predicts 90-day mortality in acute-on-chronic hepatitis B liver failure. Expert Rev Clin Immunol.2021;17(7):789-797.

(8)Han J, Wang K. Clinical significance of serum hepcidin in the diagnosis and treatment of patients with anemia of chronic disease: a meta-analysis. Biomarkers.2021;26(4):296-301.

(9)Xiang L, Chen LM, Zhai YJ, Sun WJ, Yang JR, Fan YC, Wang K. Hypermethylation of secreted frizzled related protein 2 gene promoter serves as a noninvasive biomarker for HBV-associated hepatocellular carcinoma. Life Sci.2021;270:119061.

(10)Fang Y, Yuan XD, Liu HH, Xiang L, Chen LM, Fan YC, Gao S, Wang K. 5-Aza-2'-deoxycytidine may enhance the frequency of T regulatory cells from CD4 + na?ve T cells isolated from the peripheral blood of patients with chronic HBV infection. Expert Rev Clin Immunol.2021;17(2):177-185.

(11)Qian Y, Wang JW, Fang Y, Yuan XD, Fan YC, Gao S, Wang K. Measurement of Cyclin D2 (CCND2) Gene Promoter Methylation in Plasma and Peripheral Blood Mononuclear Cells and Alpha-Fetoprotein Levels in Patients with Hepatitis B Virus-Associated Hepatocellular Carcinoma. Med Sci Monit.2020;26:e927444.

(12)Chen LM, Xiang L, Sun WJ, Zhai YJ, Gao S, Fan YC, Wang K. Diagnostic Value of the Hypomethylation of the WISP1 Promoter in Patients with Hepatocellular Carcinoma Associated with Hepatitis B Virus. Tohoku J Exp Med.2020;252(4):297-307.

(13)Wang JW, Qian Y, Wu CS, Zhao NH, Fang Y, Yuan XD, Gao S, Fan YC, Wang K. Combined use of murine double minute-2 promoter methylation and serum AFP improves diagnostic efficiency in hepatitis B virus-related hepatocellular carcinoma. Int J Med Sci.2020;17(18):3190-3199.

(14)Han J, Fan YC, Wang K. Radiofrequency ablation versus microwave ablation for early stage hepatocellular carcinoma: A PRISMA-compliant systematic review and meta-analysis.,Medicine (Baltimore) 2020;99(43):e22703.

(15)Fang Y, Xiang L, Chen LM, Sun WJ, Zhai YJ, Fan YC, Wang K. TNFRSF12A and a new prognostic model identified from methylation combined with expression profiles to predict overall survival in hepatocellular carcinoma. Transl Cancer Res.2020;9(9):5493-5507.

(16)Han LY, Yang JR, Zhao ZH, Gao S, Fan YC, Wang K. RIPK3 mRNA level acts as a diagnostic biomarker in hepatitis B virus-associated hepatocellular carcinoma. Pathol Res Pract.2020;216(10):153147.

(18)Liu HH, Fang Y, Wang JW, Yuan XD, Fan YC, Gao S, Han LY, Wang K. Hypomethylation of the cyclin D1 promoter in hepatitis B virus-associated hepatocellular carcinoma. Medicine (Baltimore).2020;99(20):e20326.

(19)Yuan XD, Wang JW, Fang Y, Qian Y, Gao S, Fan YC, Wang K. Methylation status of the T-cadherin gene promotor in peripheral blood mononuclear cells is associated with HBV-related hepatocellular carcinoma progression. Pathol Res Pract.2020;216(5):152914.

(20)Lan YT, Wang ZL, Tian P, Gong XN, Fan YC, Wang K. Treg/Th17 imbalance and its clinical significance in patients with hepatitis B-associated liver cirrhosis. Diagn Pathol.2019;14(1):114.

(21)Zhao Q, Wu C, Wang J, Li X, Fan Y, Gao S, Wang K. LncRNA SNHG3 Promotes Hepatocellular Tumorigenesis by Targeting miR-326..Tohoku J Exp Med 2019;249(1):43-56.

(22)Li FC, Fan YC, Li YK, Wang K. Plasma diamine oxidase level predicts 6-month readmission for patients with hepatitis B virus-related decompensated cirrhosis. Virol J.2019;16(1):115.

(23)Zhao NH, Qian Y, Wu CS, Wang JW, Fang Y, Fan XP, Gao S, Fan YC, Wang K. Diagnostic value of NKG2D promoter methylation in hepatitis B virus-associated hepatocellular carcinoma. Biomark Med 2019;13(13):1093-1105.

(24)Han L, Teng Y, Fan Y, Gao S, Li F, Wang K. Receptor-Interacting Protein Kinase 3 (RIPK3) mRNA Levels Are Elevated in Blood Mononuclear Cells of Patients with Poor Prognosis of Acute-on-Chronic Hepatitis B Liver Failure. Tohoku J Exp Med 2019;247(4):237-245.

(25)Zhao Q, Wu CS, Fang Y, Qian Y, Wang H, Fan YC, Wang K. Glucocorticoid Regulates NLRP3 in Acute-On-Chronic Hepatitis B Liver Failure. Int J Med Sci 2019;16(3):461-469.

(26)Wu CS, Zhao Q, Zhang J, Wang JW, Qian Y, Fan YC, Wang K. Methylation status of the stimulator of interferon genes promoter in patients with chronic hepatitis B. Medicine (Baltimore) 2018;97(52):e13904.

(27)Chen LY, Fan XP, Fan YC, Zhao J, Gao S, Li F, Qi ZX, Wang K. BATF Interference Blocks Th17 Cell Differentiation and Inflammatory Response in Hepatitis B Virus Transgenic Mice. Dig Dis Sci 2019;64(3):773-780.

(28)Wang JW, Wang JW, Zhang J, Wu CS, Fang Y, Su WW, Fan YC, Wang K. Decreased Methylation of IFNAR Gene Promoter from Peripheral Blood Mononuclear Cells Is Associated with Oxidative Stress in Chronic Hepatitis B. J Interferon Cytokine Res 2018 ;38(11):480-490.

(29)Li FC, Li YK, Fan YC, Wang K. Plasma concentration of diamine oxidase (DAO) predicts 1-month mortality of acute-on-chronic hepatitis B liver failure. Clin Chim Acta 2018;484:164-170.

(30)Li F, Qiao CY, Gao S, Fan YC, Chen LY, Wang K. Circulating cell-free DNA of methylated insulin-like growth factor-binding protein 7 predicts a poor prognosis in hepatitis B virus-associated hepatocellular carcinoma after hepatectomy. Free Radic Res 2018;52(4):455-464.

(31)Wang LY, Fan YC, Zhao J, Ji XF, Wang K. Increased BATF expression is associated with the severity of liver damage in patients with chronic hepatitis B. Clin Exp Med 2018;18(2):263-272.

(32)Tao LP, Fan XP, Fan YC, Zhao J, Gao S, Wang K. Combined detection of insulin-like growth factor-binding protein 7 promoter methylation improves the diagnostic efficacy of AFP in hepatitis B virus-associated hepatocellular carcinoma. Pathol Res Pract.2018;214(1):144-150.

(33)Fan XP, Dou CY, Fan YC, Cao CJ, Zhao ZH, Wang K. Methylation status of the estrogen receptor 1 promoter predicts poor prognosis of acute-on-chronic hepatitis B liver failure. Rev Esp Enferm Dig 2017;109(12):818-827.

(34)Lan YT, Fan XP, Fan YC, Zhao J, Wang K. Change in the Treg/Th17 cell imbalance in hepatocellular carcinoma patients and its clinical value. Medicine (Baltimore) 2017;96(32):e7704.

(35)Qiao CY, Li F, Teng Y, Zhao J, Hu N, Fan YC, Wang K. Aberrant GSTP1 promoter methylation predicts poor prognosis of acute-on-chronic hepatitis B pre-liver failure. 2018;18(1):51-62.

(36)Hu N, Fan XP, Fan YC, Chen LY, Qiao CY, Han LY, Wang K. Hypomethylated Ubiquitin-Conjugating Enzyme2 Q1 (UBE2Q1) Gene Promoter in the Serum Is a Promising Biomarker for Hepatitis B Virus-Associated Hepatocellular Carcinoma. Tohoku J Exp Med 2017;242(2):93-100.

(37)Fan YC, Zhang YY, Wang N, Sun YY, Wang K. Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) is associated with immune phases of patients with chronic hepatitis B. Oncotarget.2017;8(19):30781-30792.

(38)Liu XY, Fan YC, Gao S, Zhao J, Li F, Zhang J, Wang K. Hypermethylation of the N-Myc Downstream-Regulated Gene 2 Promoter in Peripheral Blood Mononuclear Cells is Associated with Liver Fibrosis in Chronic Hepatitis B. Tohoku J Exp Med. 2017;241(2):155-163.

(39)Tian MM, Fan YC, Zhao J, Gao S, Zhao ZH, Chen LY, Wang K. Hepatocellular carcinoma suppressor 1 promoter hypermethylation in serum. A diagnostic and prognostic study in hepatitis B. Clin Res Hepatol Gastroenterol 2017;41(2):171-180.

(40)Zhao J, Fan YC, Liu XY, Zhao ZH, Li F, Wang K. Hypermethylation of the galectin-3 promoter is associated with poor prognosis of acute-on-chronic hepatitis B liver failure. Dig Liver Dis 2017;49(6):664-671.

(41)Zhao J, Fan YC, Chen LY, Gao S, Li F, Wang K. Alteration of methyl-CpG binding domain family in patients with chronic hepatitis B. Clin Res Hepatol Gastroenterol 2017;41(3):272-283.

(42)Sun FK, Gao S, Fan YC, Shi CH, Zhang ZH, Wang LY, Li F, Li XY, Ji XF, Zhao J, Wang K. High promoter methylation levels of glutathione-S-transferase M3 predict poor prognosis of acute-on-chronic hepatitis B liver failure. Hepatol Res 2017;47(6):566-573.

(43)Gao S, Li XY, Fan YC, Sun FK, Han LY, Li F, Ji XF, Wang K. A noninvasive model to predict liver histology in HBeAg-positive chronic hepatitis B with alanine aminotransferase≤2upper limit of normal. J Gastroenterol Hepatol 2017;32(1):215-220.