学习与工作经历：

2000年-2003年 潍坊医学院硕士研究生；2003年-2006年 山东大学医学院博士研究生；2006年至今 山东大学齐鲁医院；2007年-2010年 山东大学基础医学博士后；2012年-2015年 山东大学化学博士后；2018年 美国堪萨斯大学医学中心高级访问学者。

研究方向：

体部疾病影像诊断、零磁医学，影像组学与人工智能、纳米分子成像

学术/社会兼职：

中国医师协会放射医师分会战略发展工作委员会副组长、中国研究型医院学会肿瘤影像诊断学专业委员会委员、中国医师协会放射医师分会消化学组委员、中华医学会放射学分会分子影像学组委员、山东省放射学分会副主任委员、山东省研究型医院协会影像创新与研究分会主任委员，中国医学影像整合联盟常务理事兼腹部影像专委会委员等。

获奖荣誉：

1、山东省科技进步二等奖（首位）

2、山东医学科技三等奖（首位）

3、山东省科技进步三等奖（第二位）

4、山东生物医学工程学会科学技术一等奖（第四位）

5、齐鲁卫生与健康杰出青年人才

6、全国住院医师规范化培训优秀带教老师

7、山东大学优秀临床教师

8、山东省优秀学位论文指导老师

9、齐鲁医学优秀教师

本科生课程：

断层解剖与医学影像学；医学影像学；消化系统疾病诊疗技术；核医学(双语)

研究生课程：

腹部影像诊断学；医学影像成像原理

国家自然科学基金面上项目

工信部重大项目子课题

山东省自然科学基金重大基础项目

山东省重点研发计划（重大科技创新工程）项目

山东省自然科学基金

1.       Gaorui Zhang, Jiazhi Duan, Feiran Yu, Yafei Qi, Songbo Zhao, Yuxuan Zhao, Xiaoyu Han, Hong Liu, Yuanhua Sang, Dexin Yu. GSH-Responsive Mn2+ Burst Nanoboxes as Mitophagy Intervention Agents Augment Ferroptosis and Chemoimmunotherapy in Triple-Negative Breast Cancer. Advanced Functional Materials. DOI: 10.1002/adfm.202500491

2.       Wang F, Xu X, Chen Y, Xu J, Ji W, Yu D*. Evaluation of Occult Liver Metastases in Pancreatic Adenocarcinoma by Diffusion-Weighted Related Magnetic Resonance Imaging. J Magn Reson Imaging. 2025 Mar 10. doi: 10.1002/jmri.29747.

3.       Wang F, Fan J, Lu F, Xu J, Zhang H, Han J, Chen J, Yu D. HIF-1α expression is associated with the pathological response to neoadjuvant chemotherapy in pancreatic ductal adenocarcinoma patients and can be predicted using CECT features. Quant Imaging Med Surg. 2025,15(1), 662-675. doi: 10.21037/qims-24-103.

4.       Dawei Zhou, Gaorui Zhang, Jingze Zhu, Chen Ai, Wenbo Wang, Yuxuan Zhao, Xiaoyu Han, Yafei Qi, Jiazhi Duan, Dexin Yu, Lipid acid metabolism reprogramming nanoagent induces ferroptosis storm and cGAS-STING activation for metal-immunotherapy of triple negative breast cancer, Chemical Engineering Journal, 2025, 162048, https://doi.org/10.1016/j.cej.2025.162048. 

5.       Yuxuan Zhao, Gaorui Zhang, Feiran Yu, Fang Bai, Chen Ai, Jingze Zhu, Dawei Zhou, Xinghua Xu, Hong Liu, Jiazhi Duan, Dexin Yu. Cascading catalytic nanozyme enhance ferroptosis-mediated chemoimmunotherapy via the cGAS-STING and IL-6/STAT3 pathways, Chemical Engineering Journal, 2025, 161354, https://doi.org/10.1016/j.cej.2025.161354.

6.       Yu F, Zhang G, Sun J, Zhao Y, Qi Y, Han X, Ai C, Sun W, Duan J, Yu D. Nanotension Relief Agent Enhances Tissue Penetration by Reducing Solid Stress in Pancreatic Ductal Adenocarcinoma via Rho/ROCK Pathway Inhibition. Biomater Res. 2025 Apr 9;29:0173. doi: 10.34133/bmr.0173.

7.       Lang L, Zuo L, Dou K, Fan J, Li D, Tang Y, Ji W, Yu D. The optimal slice to quantify the volumes of subcutaneous adipose tissue and skeletal muscle on chest computed tomography as imaging marker for body composition estimation. Postgrad Med J. 2025 May 14. doi: 10.1093/postmj/qgaf076.

8.       Tian R, Hou F, Zhang H, Yu G, Yang P, Li J, Yuan T, Chen X, Chen Y, Hao Y, Yao Y, Zhao H, Yu P, Fang H, Song L, Li A, Liu Z, Lv H, Yu D, Cheng H, Mao N, Song X. Multimodal fusion model for prognostic prediction and radiotherapy response assessment in head and neck squamous cell carcinoma. NPJ Digit Med. 2025 May 23;8(1):302. doi: 10.1038/s41746-025-01712-0.

9.       Fan J, Zuo L, Liu X, Tang Y, He M, Cheng Q, Yang C, Yu D. Incremental value of CT-based perirenal fat characteristics in the categorization and progression prediction of diabetic kidney disease. J Diabetes Complications. 2025 Sep;39(9):109104. doi: 10.1016/j.jdiacomp.2025.109104.

10.    Wang F, Xu X, Xu J, et al. Exploring the value of multiparametric quantitative MRI in the assessment of pancreatic ductal adenocarcinoma fibrosis grading. Eur Radiol. 2025;35(6):3625-3637. doi:10.1007/s00330-024-11246-w.

11.    Sun W, Wang H, Qi Y, Li M, Zhang R, Gao Z*, Cui J*, Yu D*. Metal-Phenolic Vehicles Potentiate Cycle-Cascade Activation of Pyroptosis and cGAS-STING Pathway for Tumor Immunotherapy. ACS Nano. 2024 Aug 27;18(34):23727-23740.

12.    An Y, Wei P, Liu L, Yimier R, Peng X, Liu D,Yu D*.Intratumoral calcification on CT assists in distinguishing benign and malignant upper abdomen neoplasm. Postgrad Med J. 2024 Sep 18: qgae118. doi: 10.1093/postmj/qgae118.

13.    Zuo L, Hou M, Fan J, Li F, Wang B, Zhao Q, Yang Y,Yu D*. Multiparametric MRI manifestations of the spontaneous intratumoral coagulative necrosis in HCC. Abdom Radiol (NY). 2024 Jul;49(7):2198-2208. doi: 10.1007/s00261-024-04355-z.

14.    Cui L, Qin Z, Sun S, Feng W, Hou M,Yu D*. Diffusion-weighted imaging-based radiomics model using automatic machine learning to differentiate cerebral cystic metastases from brain abscesses. J Cancer Res Clin Oncol. 2024 Mar 16;150(3):132. doi: 10.1007/s00432-024-05642-4.

15.    Li N, Zhang G, Zhan J*,Yu D*. pH-responsive iron-loaded carbonaceous nanoparticles for chemodynamic therapy based on the Fenton reaction. J Mater Chem B. 2024;12(16):3959-3969. doi:10.1039/d3tb02875e

16.    Fan J, Zuo L, Li F, Wang B, An Y,Yu D*. Patients with type 2 diabetes mellitus and early diabetic kidney disease exhibit lower computed tomography-measured skeletal muscle attenuation values: a propensity score-matched study. J Ren Nutr. 2024. doi:10.1053/ j.jrn.2024.04.002

17.    Wang B, Zuo L, Fan J, Ji Y, Xu L, Xu M, An Y, Zhang Y, Ji G,Yu D*. Association between higher intermuscular adipose tissue and decreased renal function in patients with systemic lupus erythematosus mediated by insulin resistance. Insights Imaging. 2024 Jun 18;15(1):144.

18.    Shuo Shi, Xin-Cheng Mao, Yong-Quan Cao, Yu-Yan Zhou, Yu-Xuan Zhao,De-Xin Yu*. CT Radiomics Features of Abdominal Adipose and Muscle Tissues Can Predict the Postoperative Early Recurrence of Hepatocellular Carcinoma, Academic Radiology,Volume, 2024, 31(4) 1312-1325, https:// doi.org /10.1016/ j.acra.2023.10.001.

19.    Wang H，Sun W，Zhou D，Qi Y，Gao Z*，Cui J*，Yu D*. Hydrogel-immobilized nanotherapeutics: Inhibition of protective autophagy to amplify STING signals for postsurgical tumor immunotherapy [J]. Chemical Engineering Journal, 2024, 480: 148211.

20.    Zuo L, Tian Z, Zhou B, Hou M, Chen Y, Han P, Ma C, Wu X,Yu D*. Perivascular fat attenuation index value and plaque volume increased in non-target lesions of coronary arteries after stenting. Eur Radiol. 2023 Dec 7. doi: 10.1007/s00330-023-10468-8.

21.    F Wang, N Li, W Wang, L Ma, Y Sun, H Wang, J Zhan*, D Yu*. A Multifunctional, Highly Biocompatible, and Double-Triggering Caramelized Nanotheranostic System Loaded with Fe3O4 and DOX for Combined Chemo-Photothermal Therapy and Real-Time Magnetic Resonance Imaging Monitoring of Triple Negative Breast Cancer. International Journal of Nanomedicine, 2023 Feb 19;18:881-897.

22.    Zhang G, Li N, Qi Y, Zhao Q, Zhan J*, Yu D*.Synergistic ferroptosis-gemcitabine chemotherapy of the gemcitabine loaded carbonaceous nanozymes to enhance the treatment and magnetic resonance imaging monitoring of pancreatic cancer. Acta Biomater. 2022 Apr 1; 142:284-297.