学习与工作经历：

2007年师从中国工程院张运院士攻读博士学位，2010年进入山东大学齐鲁医院工作。目前担任山东大学齐鲁医院心内科主任医师，科副主任；山东大学教授，博士生导师。主要从事冠心病、高血压、心力衰竭等心血管疾病的诊治，尤其擅长心血管疾病介入治疗和危重症救治。

研究方向：

心血管重构分子机制、干预靶点和预警策略；临床心血管流行病学。

学术/社会兼职：

《Journal of Geriatric Cardiology》编委

美国心脏病学院Fellow（FACC）

国家标准化心血管与代谢中心山东省中心主任

山东省医学会地方病学会副主任委员

山东医药教育协会心脏重症专业委员会主任委员

山东省医药教育协会心脏重症专业委员会主任委员

山东省医药教育协会心脏介入专业委员会副主任委员

山东省医学会心血管病学分会委员/秘书/青年学组副组长

山东省医学会心肺复苏与体外生命支持多学科联合委员会委员

获奖荣誉：

首批山东省齐鲁卫生与健康杰出青年人才，首届山东大学齐鲁医学院名医（杰出青年医师），山东大学齐鲁医院杰出青年人才。

本科生课程：

内科学

研究生课程：

临床心脏病学

（1）国家重点研发计划“心肌纤维化演变机理探索与无创精准影像评价体系构建”子课题，（项目资助号：2021YFF0501403；项目起止年月2022-01至2026-12），经费：60万。

（2）国家自然科学基金面上项目“Collectrin调控动脉粥样硬化的作用及机制研究”（项目资助号：81970366；项目起止年月2020-01至2023-12），经费：66万。

（3）国家自然科学基金面上项目“ACE2-Ang-(1-7)轴在心肌缺血再灌注损伤中的作用及其机制研究”（项目资助号：81570324；项目起止年月2016-01至2019-12），经费：68.4万。

（4）国家自然科学基金青年科学基金“JAML在动脉粥样硬化发生发展中作用机制的研究”（项目资助号：81100207；项目起止年月2012-01至2014-12），经费23万。

（5）山东省重点研发计划（科技示范工程）“重大心血管疾病智能化精准诊疗新技术开发与示范应用” 项目资助号：2021SFG0503；项目起止年月2021-10至2024-12），经费：3200万。第5位。

1. Cheng C, Zhang J, Li X, Xue F, Cao L, Meng L, Sui W, Zhang M, Zhao Y, Xi B, Yu X, Xu F, Yang J*, Zhang Y*, Zhang C*. NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice. Signal Transduct Target Ther. 2023;8:290.

2.Wu Z, Xie L, Guo D, Chen S, Liu X, Sun X, Wang J, Zhang Y, Liu L, Cui H, Zang D, Yang J*. Triglyceride-glucose index in the prediction of adverse cardiovascular events in patients without diabetes mellitus after coronary artery bypass grafting: a multicenter retrospective cohort study. Cardiovasc Diabetol. 2023;22:230.

3.Wu Z, Guo D, Chen S, Sun X, Zhang Y, Liu X, Liu L, Lin Z*, Yang J*. Combination of the triglyceride-glucose index and EuroSCORE II improves the prediction of long-term adverse outcomes in patients undergoing coronary artery bypass grafting. Diabetes Metab Res Rev. 2023:e3710.

4.Zhang S, Wu Z, Zhuang Y, Sun X, Wang J, Chen S, Guo D, Xu P, Zhang C*, Yang J*. The metabolic score for insulin resistance in the prediction of major adverse cardiovascular events in patients after coronary artery bypass surgery: a multicenter retrospective cohort study. Diabetol Metab Syndr. 2023;15:157.

5. Wu Z, Cheng C, Sun X, Wang J, Guo D, Chen S, Zhang Y, Liu X, Liu L, Zhang C*, Yang J*. The synergistic effect of the triglyceride-glucose index and serum uric acid on the prediction of major adverse cardiovascular events after coronary artery bypass grafting: a multicenter retrospective cohort study. Cardiovasc Diabetol. 2023 May 2;22(1):103.

6. Liu L, Wu Z, Zhuang Y, Zhang Y, Cui H, Lu F, Peng J*, Yang J*. Association of triglyceride-glucose index and traditional risk factors with cardiovascular disease among non-diabetic population: a 10-year prospective cohort study. Cardiovasc Diabetol. 2022 Nov 24;21(1):256.

7. Zhang Y, Cheng C, Wei F, Wu Z, Cui H, Liu L, Lu F, Peng J*, Yang J*. Reduced peak expiratory flow predicts increased risk of cardiovascular disease: A 10-year prospective cohort study in Eastern China. Respir Med Res. 2023 Jun;83:100988.

8. Wu Z, Li H, Zhang Q, Yang J*. Rare exacerbation of myocardial bridge after septal myocardial ablation in hypertrophic obstructive cardiomyopathy: a case report. Eur Heart J Case Rep. 2023 Apr 5;7(4):ytad168.

9.Wu Z, Liu L, Wang W, Cui H, Zhang Y, Xu J, Zhang W, Zheng T*, Yang J*. Triglyceride-glucose index in the prediction of adverse cardiovascular events in patients with premature coronary artery disease: a retrospective cohort study. Cardiovasc Diabetol. 2022 Jul 29;21(1):142. doi: 10.1186/s12933-022-01576-8.

10. Wu Z, Cui H, Li W, Zhang Y, Liu L, Liu Z, Zhang W, Zheng T, Yang J*. Comparison of three non-insulin-based insulin resistance indexes in predicting the presence and severity of coronary artery disease. Front Cardiovasc Med. 2022 Jul 29;9:918359. doi: 10.3389/fcvm.2022.918359.

11. Wu Z, Cui H, Zhang Y, Liu L, Zhang W, Xiong W, Lu F, Peng J*, Yang J*. The impact of the metabolic score for insulin resistance on cardiovascular disease: a 10-year follow-up cohort study. Journal of Endocrinological Investigation. 2023 Mar;46(3):523-533.

12.Zhang C, Suo M, Liu L, Qi Y, Zhang C, Xie L, Zheng X, Ma C, Li J, Yang J*, Bu P*. Melatonin Alleviates Contrast-Induced Acute Kidney Injury by Activation of Sirt3. Oxid Med Cell Longev. 2021;2021: 6668887.

13. Cheng C, Xue F, Sui W, Meng L, Xie L, Zhang C, Yang J*, Zhang Y*. Deletion of natriuretic peptide receptor C alleviates adipose tissue inflammation in hypercholesterolemic Apolipoprotein E knockout mice. J Cell Mol Med. 2021 Oct;25(20):9837-9850. doi: 10.1111/jcmm.16931.

14.Fang Y, Yang J, Zu G, Cong C, Liu S, Xue F, Ma S, Liu J, Sun Y*, Sun M*. Junctional Adhesion Molecule-Like Protein Promotes Tumor Progression and Metastasis via p38 Signaling Pathway in Gastric Cancer. Front Oncol. 2021;11:565676.

15. Wu Z, Zhang W, Yang J. Letter by Wu et al Regarding Article, "Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis". Circulation. 2021 May 11;143(19):e919-e920.

16. Xue F, Yang J, Cheng J, Sui W, Cheng C, Li H, Zhang M, Zhang J, Xu X, Ma J, Lu L, Xu J, Zhang M, Zhang Y, Zhang C*. Angiotensin-(1-7) mitigated angiotensin II-induced abdominal aortic aneurysms in apolipoprotein E-knockout mice. Br J Pharmacol. 2020;177:1719-1734.

17. Sun Y, Guan J, Hou Y, Xue F, Huang W, Zhang W, Zhang Y, Zhang C, Yang J*. Silencing of junctional adhesion molecule-like protein attenuates atherogenesis and enhances plaque stability in ApoE-/- mice. Clin Sci (Lond). 2019. 133(11): 1215-1228.

18. Zhang Q, Liu X, Li N, Zhang J, Yang J*, Bu P*. Sirtuin 3 deficiency aggravates contrast-induced acute kidney injury. J Transl Med. 2018. 16(1): 313.

19. Li W, Li J, Hao P, Chen W, Meng X, Li H, Zhang Y, Zhang C, Yang J*. Imbalance between angiotensin II and angiotensin-(1-7) in human coronary atherosclerosis. J Renin Angiotensin Aldosterone Syst. 2016. 17(3).

20. Yang J, Sun Y, Dong M, Yang X, Meng X, Niu R, Guan J, Zhang Y*, Zhang C*. Comparison of angiotensin-(1-7), losartan and their combination on atherosclerotic plaque formation in apolipoprotein E knockout mice. Atherosclerosis. 2015;240:544-549.

21. Yang J, Yang X, Meng X, Dong M, Guo T, Kong J, Zhang K, Zhang Y*, Zhang C*. Endogenous activated angiotensin-(1-7) plays a protective effect against atherosclerotic plaques unstability in high fat diet fed ApoE knockout mice. Int J Cardiol. 2015;184:645-652.

22. Hao P, Yang J(Co-first author), Liu Y, Zhang M, Zhang K, Gao F, Chen Y, Zhang C*, Zhang Y*. Combination of angiotensin-(1-7) with perindopril is better than single therapy in ameliorating diabetic cardiomyopathy. Sci Rep. 2015;5:8794.

23. Meng X, Yang J, Zhang K, An G, Kong J, Jiang F, Zhang Y*, Zhang C*. Regulatory T cells prevent angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E knockout mice. Hypertension. 2014;64:875-882.

24. Yang JM, Dong M, Meng X, Zhao YX, Yang XY, Liu XL, Hao PP, Li JJ, Wang XP, Zhang K, Gao F, Zhao XQ, Zhang MX, Zhang Y*, Zhang C*. Angiotensin-(1-7) dose-dependently inhibits atherosclerotic lesion formation and enhances plaque stability by targeting vascular cells. Arterioscler Thromb Vasc Biol. 2013;33:1978-1985.

25. Yang J, Zhao Y, Hao P, Meng X, Dong M, Wang Y, Zhang Y*, Zhang C*. Impact of angiotensin I converting enzyme insertion/deletion polymorphisms on dilated cardiomyopathy and hypertrophic cardiomyopathy risk. PLoS One. 2013;8:e63309.

26. Meng X, Li W, Yang J(Co-first author), Zhang K, Qin W, An G, Gao F, Wang Y, Zhang C*, Zhang Y*. Regulatory T cells prevent plaque disruption in apolipoprotein E-knockout mice. Int J Cardiol. 2013;168:2684-2692.

27. Yang J, Liu Z, Zhang C, Zhao Y, Sun S, Wang S, Zhao Y, Zhang Y, Li J*, Lu F*. The prevalence of hyperuricemia and its correlates in an inland Chinese adult population, urban and rural of Jinan. Rheumatol Int. 2013;33:1511-1517.

28. Zhang H#, Sun M#, Sun T, Zhang C, Meng X, Zhang Y, Yang J*(Corresponding author). Association between Angiotensin II Type 1 Receptor Gene Polymorphisms and Ischemic Stroke: A Meta-Analysis. Cerebrovasc Dis. 2011;32:431-438.

29. Zhang H#, Sun ML#, Peng J#, Sun T, Zhang Y, Yang JM*(Corresponding author). Association of the angiotensin type 1 receptor gene A1166C polymorphisms with myocardial infarction: a meta-analysis. J Thromb Haemost. 2011;9:1258-1260.

30. Yang JM, Wang Y, Qi LH, Wang Y, Gao F, Ding SF, Ni M, Liu CX, Zhang C*, Zhang Y*. Combinatorial interference of toll-like receptor 2 and 4 synergistically stabilizes atherosclerotic plaque in apolipoprotein E-knockout mice. J Cell Mol Med. 2011;15:602-611.

31. Yang J, Lu F, Zhang C, Liu Z, Zhao Y, Gao F, Sun S, Zhao Y, Zhang Y*. Prevalence of prehypertension and hypertension in a Chinese rural area from 1991 to 2007. Hypertens Res. 2010;33:331-337.