学习经历：

1995-2000年，山东医科大学，临床医学系，学士

2000-2005年，山东大学，病理学教研室，硕博连读

工作经历：

2005-2008年，山东大学病理学教研室，讲师

2008-2017年，山东大学病理学教研室，副教授

2015-2016年，美国内布拉斯加大学医学中心，访问学者

2017-2024，山东大学病理学系，主任医师

2024-至今，山东大学病理学系，教授

研究方向：

肝癌及淋巴瘤的诊断及机制研究

学术/社会兼职：

山东省医学会病理学分会淋巴瘤学组组长

国家卫生健康委能力建设和继续教育中心淋巴瘤专科建设项目病理组成员

中国抗癌协会(CACA)淋巴瘤专委会委员

中国临床肿瘤学会(CSCO)淋巴瘤专委会委员

中华医学会病理学分会淋巴造血疾病学组委员

获奖荣誉：

第三届 “人民好医生”金山茶花计划淋巴瘤领域杰出贡献奖(2023)

本科生课程：

病理学

研究生课程：

肿瘤病理学

32270820， HBP代谢重编程导致的Gfpt1-Nans-Siglec通路激活在肝癌中的作用及机制研究；国家自然科学基金；2023.1-2026.12，54万元，主持

1. Zhang C*, Li H, Wang Y, Liu W, Zhang Q, Zhang T, Zhang X, Han B, Zhou G*.Epigenetic inactivation of the tumor suppressor gene RIZ1 in hepatocellular carcinoma involves both DNA methylation and histone modifications.J Hepatol, 2010; 53(5): 889-95.

2.Zhang C, Li H, Zhou G*, Zhang Q, Zhang T, Li J, Zhang J, Hou J, Liew CT, Yin D. Transcriptional silencing of the TMS1/ASC tumor suppressor gene by an epigenetic mechanism in hepatocellular carcinoma cells. J Pathol, 2007, 212(2): 134-142.

3.Zhang, Xiaoying,Li, Hiu Ming,Liu, Zhiyan,Zhou, Gengyin,Zhang, Qinghui,Zhang, Tingguo,Zhang, Jianping,Zhang, Cuijuan*. Loss of heterozygosity and methylation of multiple tumor suppressor genes on chromosome 3 in hepatocellular carcinoma. J Gastroenterol,2013,48(1):132-143.

4. Yao, Shuzhe，Zhang, Jianping , Chen, Haiyan, Sheng, Yan, Zhang, Xiaoying, Liu, Zhiyan, Zhang, Cuijuan*. Diagnostic value ofimmunohistochemical staining of GP73, GPC3, DCP, CD34, CD31, and reticulinstaining in hepatocellular carcinoma. J Histochem Cytochem. 2013, 61(9): 639-648.

5.Cheng Zhang, Yunfgei Peng, Fan Yang, Ruixi Qin, Wenjun Liu,CuijuanZhang*. PCDH8 is Frequently Inactivated by Promoter Hypermethylation in Liver Cancer: Diagnostic and Clinical Significance. Journal of Cancer. 2016, 7(4): 446-452.

6.Sheng, Yan, Wang, Hongtao, Liu, Dongchen, Zhang, Cheng, Deng, Yupeng, Yang, Fan, Zhang, Tingguo*, Zhang, Cuijuan*.Methylation of tumorsuppressor gene CDH13 and SHP1 promoters and their epigenetic regulation by theUHRF1/PRMT5 complex in endometrial carcinoma.Gynecologic Oncology, 2016, 140(1): 145-151.

7.Chen, Haiyan, Zhang, Tingguo, Sheng, Yan, Zhang, Cheng, Peng, Yunfei, Wang, Xiao, Zhang, Cuijuan*. Methylation Profiling of Multiple TumorSuppressor Genes in Hepatocellular Carcinoma and the Epigenetic Mechanism of3OST2 Regulation. Journal of Cancer. 2015, 6(8): 740-749.

8. Chen, Haiyan^#,Zhang, Cuijuan^#,*, Sheng, Yan, Yao, Shuzhe, Liu, Zhiyan, Zhang, Cheng, Zhang, Tingguo*.Frequent SOCS3 and 3OST2 promoter methylation and their epigenetic regulation in endometrial carcinoma.American Journal of Cancer Research. 2015, 5(1): 180-190.

9.Liang K^#, Wang J^#, Wang Y, Zhou Z, Ge S, Mei S, Li H, Jing X,Zhang C*.The histologic, immunohistochemical, and genetic features of classical Hodgkin lymphoma and anaplastic large cell lymphoma with aberrant T-cell/B-cell antigen expression.Hum Pathol. 2019,84:309-320.

10.Zhang C, Ge S, Wang J, Jing X, Li H, Mei S, Zhang J, Liang K, Xu H, Zhang X,Zhang C*.Epigenomic profiling of DNA methylation for hepatocellular carcinoma diagnosis and prognosis prediction. J Gastroenterol Hepatol.2019,34(10):1869-1877.

11.Xu H, Duan N, Wang Y, Sun N, Ge S, Li H, Jing X, Liang K, Zhang X, Liu L, Xue C,Zhang C*. The clinicopathological and genetic features of ovarian diffuse large B-cell lymphoma. Pathology. 2020;52(2):206-212.

12. Wang J, Xu H, Ge S, Xue C, Li H, Jing X, Liang K, Zhang X,Zhang C*.EHMT2 (G9a) activation in mantle cell lymphoma and its associated DNA methylation and gene expression. Cancer Biol Med. 2021;19(6):836-49.

13.Yawei Feng, Shiguan Wang, Jianjun Xie, Bin Ding, Min Wang, Peng Zhang, Ping Mi, Chunxue Wang, Ruirui Liu, Tingguo Zhang, Xiaojing Yu, Detian Yuan,Cuijuan Zhang*.Spatial transcriptomics reveals heterogeneity of macrophages in the tumor microenvironment of granulomatous slack skin.J Pathol.2023;261(1):105-119.

14.Zhang X, Liang K, Chen H, Liu L, Liu R, Wang C,Zhang C*.Genomic analysis reveals molecular characterization of CD30+ and CD30- extranodal natural killer/T-cell lymphomas (ENKTLs).Hum Pathol. 2024 Aug 24;152:105650.