学习与工作经历：     

教育经历

2009.9 - 2014.6     吉林大学，病理学与病理生理学，   硕博连读

2002.9 - 2007.6     山东大学，护理学，               学士

工作经历

2018.6 – 至今      山东大学护理与康复学院， 教授、博士生导师

2013.8 - 2014.6     美国路易斯维尔大学，     博士后研究员

研究方向：

老年与慢性病发病机制与康护

学术/社会兼职：

山东省营养学会常务理事、委员

山东省康复医学护理学会委员

获奖荣誉：

山东省泰山学者青年专家

山东省优秀硕士学位论文指导教师

山东大学齐鲁青年学者

省部级自然科学学术成果奖一等奖

本科生课程：

《儿科护理学》、《Pediatric Nursing》、《新生研讨课》

研究生课程：

《临床护理研究思路与方法》

1.82272601，FGF21介导有氧运动改善衰老心肌易损性的作用及机制研究，国家自然科学基金面上项目，2024.01-2026.12，52万元，主持人

2.8160063，成纤维细胞生长因子 21 通过抑制 p53 活性对糖尿病心肌病保护作用的研究国家自然科学基金青年项目，2017.01-2019.12，17万元 主持人

3.ZR2021MH330，P53-TRB3信号通路在SFN改善心肌胰岛素抵抗治疗糖尿病心肌病的作用和机制研究，省自然科学基金面上项目，10万元，主持人

（1）Ting Gao, Yufeng Tang, Tao Zeng, Jie Wang, Xiaohui Zhang, Qingbo Liu, Xun Guan, Xinyu Tang, Guangping Lu, Jiahao Li, Mingrui Liu, Dongmei Zhang, Sixuan Lv, Junlian Gu*. Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α. Advanced Science. 2025.

（2）Yuanfang Guo, Jie Wang, Dongmei Zhang, Yufeng Tang, Quanli Cheng, Jiahao Li, Ting Gao, Xiaohui Zhang, Guangping Lu, Mingrui Liu, Xun Guan, Xinyu Tang, Junlian Gu*. Diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of NADPH oxidase 4. Acta Pharmaceutica Sinica B. Available online 2025 Jan 2.

（3）Guangping Lu, Yufeng Tang, Ou Chen, Yuanfang Guo, Mengjie Xiao, Jie Wang, Qingbo Liu, Jiahao Li, Ting Gao, Xiaohui Zhang, Jingjing Zhang, Quanli Cheng, Rong Kuang, Junlian Gu*. Aberrant activation of p53-TRIB3 axis contributes to diabetic myocardial insulin resistance and sulforaphane protection. Journal of Advanced Research. 2024 Jul 26:S2090-1232(24)00307-2.

（4）Jiahao Li, Yufeng Tang, Guangping Lu, Qingbo Liu, Yuanfang Guo, Jie Wang, Mengjie Xiao, Ting Gao, Xiaohui Zhang, Junlian Gu*. Elevation of p53 sensitizes obese kidney to adriamycin-induced aberrant lipid homeostasis via repressing HNF4α-mediated FGF21 sensitivity. Journal of Advanced Research. 2024 Jul 15:S2090-1232(24)00299-6.

（5）Jie Wang, Ting Gao, Dongmei Zhang, Yufeng Tang, Junlian Gu*. Phospholipase C epsilon 1 as a therapeutic target in cardiovascular diseases. Journal of Advanced Research. 2025 Jan 22:S2090-1232(25)00051-7.

（6）Mengjie Xiao, Yufeng Tang, Jie Wang (a) , Guangping Lu, Jianlou Niu, Jie Wang (b), Jiahao Li, Qingbo Liu, Zhaoyun Wang, Zhifeng Huang, Yuanfang Guo, Ting Gao, Xiaohui Zhang, Shouwei Yue, Junlian Gu*. A new FGF1 variant protects against adriamycin-induced cardiotoxicity via modulating p53 activity. Redox Biology. 2022 Feb:49:102219.

（7）Jie Wang A, Yufeng Tang, Jingjing Zhang, Jie Wang B, Mengjie Xiao, Guangping Lu, Jiahao Li, Qingbo Liu, Yuanfang Guo, Junlian Gu*. Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2. Redox Biology. 2022 Jun:52:102310.

（8）Junlian Gu†, Xiaoqing Yan†, Xiaozhen Dai, Yuehui Wang, Qian Lin, Jian Xiao, Shanshan Zhou, Jian Zhang, Kai Wang, Jun Zeng, Ying Xin, Michelle T Barati, Chi Zhang, Yang Bai, Yan Li, Paul N Epstein, Kupper A Wintergerst, Xiaokun Li, Yi Tan, Lu Cai. Metallothionein preserves Akt2 activity and cardiac function via inhibiting TRB3 in diabetic hearts. Diabetes. 2018 Mar;67(3):507-517.

（9）Junlian Gu†, Yanli Cheng†, Hao Wu, Lili Kong, Shudong Wang, Zheng Xu, Zhiguo Zhang, Yi Tan, Bradley B Keller, Honglan Zhou, Yuehui Wang, Zhonggao Xu, Lu Cai. Metallothionein is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy. Diabetes. 2017 Feb;66(2):529-542.

（10）Zhifeng Huang†, Yi Tan†, Junlian Gu†, Yang Liu, Lintao Song, Jianlou Niu, Longwei Zhao, Lakshmi Srinivasan, Qian Lin, Jingjing Deng, Yang Li, Daniel J Conklin, Thomas A Neubert, Lu Cai, Xiaokun Li, Moosa Mohammadi. Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability. Cell Reports. 2017 Aug 15;20(7):1717-1728.

（11）Mengjie Xiao, Yufeng Tang, Jie Wang A, Jie Wang B, Guangping Lu, Yuanfang Guo, Jingjing Zhang, Junlian Gu*. Regulatory role of endogenous and exogenous fibroblast growth factor 1 in the cardiovascular system and related diseases. Pharmacological Research. 2021 Jul:169:105596.

（12）Jie Wang B, Shudong Wang, Mengjie Xiao, Jingjing Zhang, Jie Wang A , Yuanfang Guo, Yufeng Tang, Junlian Gu*. Regulatory mechanisms of Sesn2 and its role in multi-organ diseases. Pharmacological Research. 2021 Feb:164:105331.

（13）Guangping Lu, Jiahao Li, Ting Gao, Qingbo Liu, Ou Chen, Xiaohui Zhang, Mengjie Xiao, Yuanfang Guo, Jie Wang, Yufeng Tang, Junlian Gu*. Integration of dietary nutrition and TRIB3 action into diabetes mellitus. Nutrition Reviews. 2024 Feb 12;82(3):361-373.

（14）Ting Gao, Jie Wang (b), Mengjie Xiao, Jie Wang (a), Shudong Wang, Yufeng Tang, Jingjing Zhang, Guangping Lu, Hua Guo, Yuanfang Guo, Qingbo Liu, Jiahao Li, Junlian Gu*. SESN2-Mediated AKT/GSK-3β/NRF2 Activation to Ameliorate Adriamycin Cardiotoxicity in High-Fat Diet-Induced Obese Mice. Antioxid Redox Signal. 2024 Apr;40(10-12):598-615.

（15）Jianlou Niu†, Jing Zhao†, Jiamin Wu†, Guanting Qiao, Junlian Gu, Chuanren Zhou, Qi Li, Lei Ying, Dezhong Wang, Huan Lin, Xiaokun Li, Moosa Mohammadi , Zhifeng Huang. Curtailing FGF19's mitogenicity by suppressing its receptor dimerization ability. Proceedings of the National Academy of Sciences of the United States of America. 2020 Nov 17;117(46):29025-29034.