学习与工作经历：

2006/9 - 2011/6，山东大学，生理学，博士，导师：郝爱军

2000/9 - 2003/6，山东大学，生理学，硕士，导师：陈连璧

1993/9 - 1998/6，新乡医学院，临床医学，学士

2014/9 - 至今，山东大学，医学院，副教授

2016/2 - 2017/1，美国肯塔基大学，医学院，访问学者

2011/11 - 2014/10, 山东大学，医学院，博士后，已出站

2008/8 - 2009/12，美国肯塔基大学，医学院Gill Heart心脏病研究所，访问学者

2005/9 - 2014/8，山东大学，医学院，讲师

研究方向：

中枢神经系统损伤及功能康复的研究。

学术/社会兼职：

获奖荣誉：

本科生课程：

生理学，人体结构与功能，生理学实验，医学机能学实验

研究生课程：

神经系统疾病基础与临床

1. 国家自然科学基金（面上项目）：82271327, M1区神经元激活释放的EVs介导miR-100-5p motif/TLR7在缺血性脑卒中的作用及机制研究，2023.01-2026.12，52万，在研，主持。

2. 国家自然科学基金（面上项目）：82072535，基于小胶质细胞OPN/CTSB/NLRP3轴介导的炎症反应探讨H2S促进缺氧缺血性脑损伤后神经功能重建的机制研究，2021.01-2024.12，55万，在研，主持。

3. 国家自然科学基金（面上项目）：81873768，H2S调控BMSCs外泌体相关miR-9/TN-C轴对HIBD后的神经保护作用及机制研究，2019.01-2022.12，56万，在研，主持。

4. 国家自然科学基金（面上项目）：81671213，利用条件基因敲除技术研究内源性H2S调控Shh通路对HIBD后新生小鼠海马神经再生的影响，2017.01-2020.12，57万，已结题，主持。

5. 山东省重点研发计划项目：2017GSF218091，左旋半胱氨酸调控Sonic Hedgehog通路对SAH大鼠及患者后认知功能障碍的影响及临床应用初探，2018.01-2019.12，10万，已结题，主持。

6. 山东大学基本科研业务费（交叉学科培育）项目：2015JC008，左旋半胱氨酸在脑出血后认知障碍中的临床应用及机制研究，2015.01-2017.12，35万，已结题，主持。

7. 中国博士后科学基金特别资助，2013T60672，硫化氢对缺血缺氧性脑损伤神经系统发育的影响及机制，2013.07-2015.07，15万，已结题，主持。

8. 国家自然科学基金（青年科学基金项目），81200879，饱和脂肪酸对胚胎神经系统发育的影响及机制研究，2013年01月- 2015年12月，23万，已结题，主持。

9. 山东大学自主创新基金：IIFSDU2012TS120，硫化氢对神经干细胞增殖分化的影响及其机制研究，2013.01-2015.12，7万，已结题，主持。

10. 中国博士后科学基金面上资助，2012M511514，孕期肥胖对胚胎神经系统发育的影响及机制研究，2012.05-2013. 12，5万，已结题，主持。

11. 山东省自然科学基金（青年项目），ZR2011HQ035，清道夫受体CD36在脂肪组织脂类代谢和炎症反应中的作用及机制的研究，2011.07-2014.07，5万，已结题，主持。

1. Chu Xili, Liu Dexiang, Li Tingting, Ke HongFei, Xin Danqing, Wang Shuhan, Cao Ying, Xue Hao,Wang Zhen*（王贞）. Hydrogen sulfide-modified extracellular vesicles from mesenchymal stem cells for treatment of hypoxic-ischemic brain injury. Journal of Controlled Release. 2020 December, 328 (10); 13-27.PubMed(IF 10.413).

2. Xin Danqing, Li Tingting, Chu Xili, Ke Hongfei, Yu Zhuoya, Cao Lili, Bai Xuemei, Liu Dexiang,Wang Zhen*（王贞）.Mesenchymal stromal cell-derived extracellular vesicles modulate microglia/macrophage polarization and protect the brain against hypoxia-ischemic injury in neonatal mice by targeting delivery of miR-21a-5p. Acta Biomaterialia. 2020 Sep 1; 113:597-613.PubMed(IF 9.000).

3. Xin Danqing, Li Tingting, Chu Xili, Xin Danqing Liu Dexiang,Wang Zhen*（王贞）. MSCs-extracellular vesicles attenuated neuroinflammation, synapse damage and microglial phagocytosis after hypoxia-ischemia injury by preventing osteopontin expression. Pharmacological Research. 2021 Feb; 164:105322.PubMed(IF 7.374).

4. Li Tingting ,Xin Danqing ,Ke Hongfei, Chu Xili, Zhao Yijing, Yue Shouwei, Liu Dexiang*,Wang Zhen*（王贞）.L-Cysteine attenuates osteopontin-mediated neuroinflammation following hypoxia-ischemia insult in neonatal mice by inducing S-sulfhydration of Stat3.Acta Pharmacologica Sinica.2022 Jul;43(7):1658-1669.(IF 7.169).

5. Xin Danqing, Chu Xili, Bai Xuemei, Ma Weiwei,Yuan Hongtao,Qiu Jie,Changxing Liu,Tong Li,Xin Zhou,Wenqiang Chen, Liu Dexiang,Wang Zhen*（王贞）. L-Cysteine suppresses hypoxia-ischemia injury in neonatal mice by reducing glial activation, promoting autophagic flux and mediating synaptic modification via H₂S formation. Brain Behavior and Immunity. 2018 October; 73:222-234.PubMed(IF 6.616).

6. Liu Song, Xin Danqing, Wang Lingxiao, Zhang Tiantian,Bai Xuemei,Li Tong,Xie Yuankai,Xue Hao, Bo Shishi, Liu Dexiang,Wang Zhen*（王贞）.Therapeutic effects of L-Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H₂S system: role of oxidative stress and endoplasmic reticulum stress. Redox Biology.2017 July 14; 13:528-540.PubMed(IF 7.613).

7. Chu Xili, Cao Lili, Yu Zhuoya, Xin Danqing, Li Tingting, Ma Weiwei, Zhou Xin,Chen Wenqiang,Liu Dexiang,Wang Zhen*（王贞）.Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation. Journal of Neuroinflammation. 2019 May 18; 16(1):104.PubMed(IF 6.162).

8. Xin Danqing , Zhao Yijing, Li Tingting , Ke Hongfei, Gai Cheng-Cheng, Guo Xiaofan, Chen Wenqiang, Liu Dexiang*,Wang Zhen*（王贞）. The delivery of miR-21a-5p by extracellular vesicles induces microglial polarization via the STAT3 pathway following hypoxia-ischemia in neonatal mice. Neural Regeneration Research. 2022 Oct;17(10):2238-2246. doi: 10.4103/1673-5374.336871.(IF 6.058).

9. Li Tingting, Chu Xili, Xin Danqing, Ke Hongfei, Wang Shuhan, Liu Dexiang, Chen Wenqiang,Wang Zhen*（王贞）. H₂S prevents peripheral immune cell invasion, increasing [Ca²⁺]i and excessive phagocytosis following hypoxia-ischemic injury in neonatal mice.  Biomedicine & Pharmacotherapy. 2021 Mar;135:111207.PubMed(IF 5.979).

10. Han Min, Cao Ying, Guo Xiaofan, Chu Xili, Li Tingting, Xue Hao, Xin Danqing, Yuan Lin, Ke Hongfei, Gang Li*,Wang Zhen*（王贞）. Mesenchymal stem cell-derived extracellular vesicles promote microglial M2 polarization after subarachnoid hemorrhage in rats and involve the AMPK/NF-κB signaling pathway. Biomedicine & Pharmacotherapy.2021 Jan; 133:111048.PubMed(IF 5.979).

11. Li Tingting^#, Li Jiangbing^#, Li Tong^#, Zhao Yijing, Ke Hongfei, Wang Shuanglian, Liu Dexiang*, andWang Zhen**（王贞）. L-Cysteine provides neuroprotection of hypoxia-ischemia injury in neonatal mice via a PI3K/Akt-dependent mechanism.Drug Design Development and Therapy.2021 Feb 11; 15:517-529.PubMed(IF 4.278).

12. Liu Dexiang^#,Bai Xuemei^#, Ma Weiwei, Xin Danqing, Chu Xili, Yuan Hongtao, Qiu Jie,Ke Hongfei,Yin Sen,Chen Wenqiang,Wang Zhen*（王贞）. Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling. Frontiers in Pharmacology. 2020 Mar 4; 11:204.PubMed(IF 6.005).

13. Han Min^#, Liu Dexiang^#,Qiu Jie,Yuan Hongtao, Hu Quan, Xue Hao, Li Tingting, Ma Weiwei, Zhang Qiong, Li Gang*,Wang Zhen*（王贞）.Evaluation of H₂S-producing enzymes in cerebrospinal fluid and its relationship with interleukin-6 and neurologic deficits in subarachnoid hemorrhage. Biomedicine & Pharmacotherapy. 2020 Mar; 123:109722.PubMed(IF 5.979).

14. Xiong Ye^#, Xin Danqing^#, Hu Quan^#, Wang Lingxiao,Qiu Jie,Yuan Hongtao, Chu Xinli, Liu Dexiang, Li Gang*,Wang Zhen*（王贞）.Neuroprotective Mechanism of L-cysteine After Subarachnoid Hemorrhage. Neural Regeneration Research. 2020 Oct; 15(10):1920-1930.PubMed(IF 3.983).

15. Han Min, Cao Ying, Xue Hao, Chu Xili, Li Tingting, Xin Danqing, Yuan Lin, Ke Hongfei, Li Gang*, andWang Zhen*（王贞）. Neuroprotective Effect of Mesenchymal Stromal Cell-Derived Extracellular Vesicles Against Cerebral Ischemia-Reperfusion-Induced Neural Functional Injury: A Pivotal Role for AMPK and JAK2/STAT3/NF-κB Signaling Pathway Modulation. Drug Design Development and Therapy. 2020 Jul 20; 14:2865-2876.PubMed(IF 4.278).

16. Ke Hongfei^#, LiuDexiang^#, Li Tingting , Chu Xili, Xin Danqing, Han Min, Wang Shuanglian,Wang Zhen*（王贞）.Hydrogen-Rich Saline Regulates Microglial Phagocytosis and Restores Behavioral Deficits Following Hypoxia-Ischemia Injury in Neonatal Mice via the Akt Pathway. Drug Design Development and Therapy. 2020 Sep 21; 14:3827-3839.PubMed(IF 4.278).

17. Zhou Xin^#, Chu Xili^#, Xin Danqng, Li Tingting, Bai Xuemei,Qiu Jie,Yuan Hongtao, Liu Dexiang, Wang Dachuan ,Wang Zhen*（王贞）. L-Cysteine-Derived H₂S Promotes Microglia M2 Polarization via Activation of the AMPK Pathway in Hypoxia-Ischemic Neonatal Mice.Frontier in Molecular Neuroscience.2019 March 11; 12:58.PubMed(IF 4.351).

18. Yang Chunlei^#, Tong Li^#, Xue Hao, Wang Lingxiao, Deng Lin, Xie Yunkai, Bai Xuemei, Xin Danqing,Yuan Hongtao,Qiu Jie,Wang Zhen*（王贞）, Gang Li*. Inhibition of Necroptosis Rescues SAH-Induced Synaptic Impairments in Hippocampus via CREB-BDNF Pathway.Frontier in Neuroscience.2019 January 7;12:990.PubMed(IF 4.229).

19. Li Jiangbing,Xue Hao,Li Tingting,Chu Xili,Xin Danqing,Xiong Ye,Qiu Wei,Gao Xiao,Qian Mingyu,Xu Jiangye,Wang Zhen*（王贞）,Li Gang*.Exosomes derived from mesenchymal stem cells attenuate the progression of atherosclerosis in ApoE-/- mice via miR-let7 mediated infiltration and polarization of M2 macrophage.Biochemical and Biophysical Research Communications.2019 March 19:565-572.PubMed(IF 2.750).

20. Xie Yunkai^#, Zhou Xin^#,Yuan Hongtao,Qiu Jie, Xin Danqing, Chu Xili, Wang Dachuan*,Wang Zhen*（王贞）. Resveratrol reduces brain injury after subarachnoid hemorrhage by inhibiting oxidative stress and endoplasmic reticulum stress. Neural Regeneration Research. 2019 Oct; 14(10):1734-1742.PubMed(IF 2.637).

21. Li Tong^#, Wang Lingxiao^#, Hu Quan, Liu Song, Bai Xuemei, Xie Yuankai, Zhang Tiantian, Bo Shishi, Gao Xiangqian, Wu Shuhua, Li Gang*,Wang Zhen*（王贞）.Neuroprotective Roles of L-Cysteine in Attenuating Early Brain Injury and Improving Synaptic Density via the CBS/H₂S Pathway Following Subarachnoid Hemorrhage in Rats.Frontiers in Neurology. 2017 May 2; 8:176.PubMed(IF 4.297).

22. Ge Li, Wei Lihua, Du Changqing, Song Guohua, Xue Yazhuo, Shi Haoshen, Yang Ming, Yin Xinxin, Li Runting, Wang Xueer,Wang Zhen*（王贞）,Song Wen-Gang*.Hydrogen-rich saline attenuates spinal cord hemisection-induced testicular injury in rats.Oncotarget.2017 June 27; 8(26):42314-42331PubMed(IF ).

23. Hu Quan^#,Li Tong^#, Wang Lingxiao, Xie Yunkai, Liu Song, Bai Xuemei, Zhang Tiantian, Bo Shishi, Xin Danqing, Xue Hao, Li Gang*,Wang Zhen*（王贞）.Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats. Frontiers in Cellular Neuroscience. 2017 Januarly 18; 10:306PubMed(IF 4.915).

24. Li Tong,Liu Hansen,Xue Hao,Zhang Jinsen,Han Xiao,Yan Shaofeng,Bo Shishi,Liu Song,Yuan Lin,Deng Lin,Li Gang*,Wang Zhen*（王贞）. Neuroprotective effects of hydrogen sulfide against early brain injury and secondary cognitive deficits following subarachnoid hemorrhage.Brain Pathology. 2017Januarly; 27(1):51-63.PubMed(IF 5.564).

25. Bai Xuemei, Liu Song, Yuan Lin, XieYunka, Li Tong, WangLingxiao, WangXueer, ZhangTiantian, QinShucun, SongGuohau, Ge L*,Wang Zhen*（王贞）.Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice.Brain Research. 2016September 1; 1646:410-7.PubMed(IF 2.750).

26. Zhang Qun, Liu Song, Li Tong, Yuan Lin, Liu Hansen, Wang Xueer, Wang Fuwu, Wang Shuanglian, Hao Aijun, Liu Dexiang*,Wang Zhen*（王贞）. Preconditioning of bone marrow mesenchymal stem cells with hydrogen sulfide improves their therapeutic potential.Oncotarget.2016 September 6; 7(36):58089-58104.PubMed(IF 5.312).

27. Yuan Lin, Liu Song, Bai Xuemei, Gao Yan, Liu Guangheng, Wang Xueer, Liu Dexiang, Li Tong, Hao Aijun,Wang Zhen*（王贞）.Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice.Journal of Neuroinflammation. 2016 April 13; 13(1):77.PubMed(IF 5.717).

28. Zhang Qun^#, Yuan Lin^#, Zhang Qingrui, Gao Yan, LiuGuangheng, Xiu Meng, Wei Xiang,Wang Zhen*（王贞）, Liu Dexiang*.Resveratrol attenuates hypoxia-induced neurotoxicity through inhibiting microglial activation. International Immunopharmacology. 2015 July 27; 28(1):578-587.PubMed(IF 2.752).

29. Zhang Qun, Yuan Lin, Liu Dexiang, Wang Jianmei, Wang Shuanglin, Zhang Qingrui, Gong Yanfeng, Liu Hongdao, Hao Aijun,Wang Zhen*（王贞）.Hydrogen sulfide attenuates hypoxia-induced neurotoxicity through inhibiting microglial activation.Pharmacological Research. 2014 June; 84:32-44.PubMed(IF 4.409).

30. Liu Dexiang,Xie Kai,Yang Xudong,Gu Jianhua,Ge Li,Wang Xueer,Wang Zhen*（王贞）.Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in rats. Behavioural Brain Research.2014 May 1; 264:9-16.PubMed(IF 3.298).

31. Liu Dexiang^#,Zhang Qingrui,Gu Jianhua,Wang Xueer,Xie Kai,Xian Xiuying,Wang Jianmei,Jiang Hong,Wang Zhen*（王贞）.Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats.Progress in Neuro-Psychopharmacology and Biological Psychiatry.2014 March 3; 49:21-9.PubMed(IF 3.797).

【第一作者论文】:

1. Wang Zhen（王贞）,Zhang Qun,Yuan Lin, Wang Shuanglian,Liu Liwei,Yang Xudong,Li Ge*, Liu Dexiang*.The effects of curcumin on depressive-like behavior in mice after lipopolysaccharide administration. Behavioural Brain Research. 2014 November 1; 274:282-90.PubMed(IF 3.298).

2. Wang Zhen（王贞）,Liu Dexiang,Zhang Qun,Wang Jianmei,Zhan Jingmin, Xian Xiuying, Du Zhaoxia, Wang Xueer,Hao Aijun*.Palmitic acid affects proliferation and differentiation of neural stem cellsin vitro.Journal of Neuroscience Research, 2014 May; 92(5):574-86.PubMed(IF 2.772).

3. Jiang Hong^#,Wang Zhen^#（王贞）, Wang Yihe, Xie Kai, Zhang Qingrui, Luan Qinsong, Chen Wenqiang, Liu Dexiang*. Antidepressant-like effects of curcumin in chronic mild stress of rats: Involvement of its anti-inflammatory action.Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2013 December 2; 47:33-9PubMed(IF 3.819).

4. Wang Zhen（王贞）, Liu Dexiang, Zhan Jingmin, Xie Kai, Wang Xueer, Xian Xiuying, Gu Jianhua, Chen Wenqiang, Hao Aijun*. Melatonin improves short and long-term neurobehavioral deficits and attenuates hippocampal impairments after hypoxia in neonatal mice. Pharmacological Research. 2013 Octorber; 76:84-97.PubMed(IF 4.483).

5. Wang Zhen（王贞）, Liu Dexiang, Wang Fuwu, Zhang Qun, Du Zhaoxia, Zhan Jingmin, Yuan Qiuhuan, Ling Eng-Ang, Hao Aijun*.L-cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/H₂S pathway.Neuroscience.2013 May 1,237:106-117.PubMed(IF 3.458).

6. Wang Zhen（王贞）, Zhan Jingmin, Wang Xueer, Gu Jianhua, Xie Kai, Zhang Qingrui, Liu Dexiang*. Sodium hydrosulfide preventshypoxia-induced behavioral impairment in neonatal mice. Brain Research. 2013 November13; 1538:126-34.PubMed(IF 2.957).

7. Wang Zhen（王贞）,Gu Jianhua,Wang Xueer,Xie Kai,Luan Qingsong,WanNianqing,Zhang Qun,Jiang Hong,Liu Dexiang*.Antidepressant-like activity of resveratrol treatment in the forced swim test and tail suspension test in mice: the HPA axis, BDNF expression and phosphorylation of ERK. Pharmacology Biochemistry and Behavior. 2013 November 1; 112:104-10.PubMed(IF 2.772).

8. Wang Zhen^#（王贞）,Liu Dexiang^#, Wang Fuwu, Liu Shangming, Zhao Shidou, Ling Eng-Ang, Hao Aijun*.Saturated fatty acids activate microglia via Toll-like receptor 4/nuclear factor κB signaling. British journal of nutrition. 2012 January 28; 107(2):229-41.PubMed(IF 3.596).

9. Cai Lei^#,Wang Zhen^#（王贞）, Ji Ailing, Meyer Jason M, van der Westhuyzen Deneys R*. Scavenger receptor CD36 expression contributes to adipose tissue inflammation and cell death in diet-induced obesity. Plos one. 2012 May 16;7 (5): e36785.PubMed(IF 4.244).

10. Wang Zhen（王贞）,Liu Dexiang, Wang Juntao, Liu Shangming, Gao Ming, Ling Eng-Ang, Hao Aijun*.Cytoprotective effects of melatonin on astroglial cells subjected to palmitic acid treatment in vitro.Journal of pineal research.2012 Mar;52(2):253-64PubMed(IF 5.451).

11. Liu Dexiang^#,Wang Zhen^#（王贞）,Liu Shangming,Wang Fuwu,Zhao Shidou,Hao Aijun*. Anti-inflammatory effects of fluoxetine in lipopolysaccharide (LPS)-stimulated microglial cells.Neuropharmacology.2011 September; 61(4):592-9.PubMed(IF 3.901).