学习与工作经历：

2020.4-至今，山东大学，基础医学院，副研究员

2016/1-2020.3，山东大学，基础医学院，博士后，合作导师:龚瑶琴/马春红

2012/09-2015/12，中国农科院上海兽医研究所，博士，导师：马志永

2009/09-2012/06，山东农业大学，硕士，导师：崔治中

研究方向：

主要从事病毒感染与宿主相互作用研究，致力于发现HBV等病毒感染调控的关键宿主因子及靶向干预新策略

学术/社会兼职：

获奖荣誉：

本科生课程：

医学免疫学、生物医学科学讨论课3、免疫与相关疾病PBL、医学综合试验2、感染免疫与相关疾病(双语1)实验

研究生课程：

1.国家自然科学基金面上项目，82271769，Tim-3棕榈酰化修饰调控CTL/NK细胞功能耗竭的作用及机制研究，2023/1-2026/12，52万元，在研，主持

2.国家自然科学基金青年基金，81902051，ABCF1识别HBV_cccDNA诱导IFN-Lambda应答抑制HBV复制的作用及分子机制，2020/1-2022/12，20万元，在研，主持

3.山东省重点研发计划（公益类），2019GSF108238，ABCF1识别HBV cccDNA诱导IFN-Lambda应答抑制HBV复制的作用机制及应用研究，2019/1-2021/12，15万元，在研，主持

4.武专昌，泰山学者青年专家（tsqn202306008），2023.1.1-2025.12.31, 75万

5.武专昌，山东大学青年学者未来计划，2020.9-2025.8，50万

6.武专昌，山东大学齐鲁医学院高层次人才培育项目B类，2023.1.1-2025.12.31，20万

1.Wang M^#, Zhang J^#, Dou Y^#, Liang M, Xie Y, Xue P, Liu L, Li C, Wang Y, Tao F, Zhang X, Hu H, Feng K, Zhang L,Wu Z*, Chen Y*, Zhan P*, Jia H*. Design, Synthesis, and Biological Evaluation of Novel Thioureidobenzamide (TBA) Derivatives as HBV Capsid Assembly Modulators. J Med Chem. 2023 Oct 26;66(20):13968-13990.

2.Wu Z^#, Lei X^#, Wang X^#, Zhang Z, Li Y, Gao L, Liang X, Wang P, Wang J*, Ma C*. Peptide targeting the interaction of S protein cysteine-rich domain with Ezrin restricts pan-coronavirus infection. Signal Transduct Target Ther. 2023 Jan 18;8(1):19.

3.Li N^#,Wu Z^#, Ma C*. ZHX2 in health and disease. Front Oncol. 2022 Nov 18;12:1038890. doi: 10.3389/fonc.2022.1038890.

4.Wu Z, Wang L, Wang X, Sun Y, Li H, Zhang Z, Ren C, Zhang X, Li S, Lu J, Xu L, Yue X, Hong Y, Li Q, Zhu H, Gong Y, Gao C, Hu H, Gao L, Liang X, Ma C. cccDNA Surrogate MC-HBV-Based Screen Identifies Cohesin Complex as a Novel HBV Restriction Factor. Cell Mol Gastroenterol Hepatol. 2022;14(6):1177-1198.

5.Sun Y, Teng Y, Wang L, Zhang Z, Chen C, Wang Y, Zhang X, Xiang P, Song X, Lu J, Li N, Gao L, Liang X, Xia Y*,Wu Z*, Ma C*. LINC01431 Promotes Histone H4R3 Methylation to Impede HBV Covalently Closed Circular DNA Transcription by Stabilizing PRMT1. Adv Sci (Weinh). 2022 Apr 10:e2103135.

6.Wang L, Sun Y, Song X, Wang Z, Zhang Y, Zhao Y, Peng X, Zhang X, Li C, Gao C, Li N, Gao L, Liang X,Wu Z*, Ma C*. Hepatitis B virus evades immune recognition via RNA adenosine deaminase ADAR1-mediated viral RNA editing in hepatocytes. Cell Mol Immunol. 2021 Aug;18(8):1871-1882.

7.Wu Z^#,*, Zhang Z^#, Wang X^#, Zhang J^#, Ren C, Li Y, Gao L, Liang X, Wang P*, Ma C*. Palmitoylation of SARS-CoV-2 S protein is essential for viral infectivity. Signal Transduct Target Ther. 2021 Jun 11;6(1):231.

8.Wang X^#,Wu Z^#, Li Y, YangY,Xiao C, Liu X, Xiang X, Wei J, Shao D, Liu K, Deng X, Wu J, Qiu Y, Li B*, Ma Z*: p53 promotes ZDHHC1-mediated IFITM3 palmitoylation to inhibit Japanese encephalitis virus replication. Plos Pathogens. 2020 Oct;16(10):e1009035.

9.Wu Z^#, MaH^#, Wang L, Song X, Zhang J, LiuW, Ge Y, Sun Y, Yu X, Wang Z, Wang J, Zhang Y, Li C, Li N, Gao L, Liang X, Yue X*, Ma C*: Tumor suppressor ZHX2 inhibits NAFLD-HCC progression via blocking LPL-mediated lipid uptake.Cell Death and Differentiation.2020 May;27(5):1693-1708.

10.Wu Z,XiaX, Li H, Jiang S, Ma Z*, Wang X*: Tandem repeat sequence of duck circovirus serves as downstream sequence element to regulate viral gene expression. Veterinary microbiology.2019 Dec;239:108496.