学习与工作经历：

1988.09-1993.07 山东大学口腔医学院 本科

1993.07-1999.09 山东省立医院口腔科 主治医师

1999.09-2002.07 山东大学口腔医学院 硕士研究生

2002.09-2005.07 四川大学华西口腔医学院 博士研究生

2005.07-至今 山东大学口腔医院正畸科 教授，主任医师，博士生导师

2005.12-2009.10 北京大学口腔医院 博士后

2009.12-2010.12 美国南加州大学牙学院 访问学者

2012.09-2012.10 日本大学齿学部 访问学者

研究方向：

长期从事口腔正畸临床和基础研究工作，主要研究方向为口腔疾病数字化智能诊治、牙周组织微环境适应牙齿正畸应力的相关机制、正畸牙移动与代谢性骨病等方面的研究。

学术/社会兼职：

中华口腔医学会正畸专委会常委

中华口腔医学会教育专委会常委

山东省医师学会口腔科医师分会副会长

山东省医学会口腔分会副会长

国际牙医师学院（ICD）Fellow

国家十四五规划教材《口腔正畸学》编委

《中华口腔正畸学》杂志、《口腔医学》杂志编委

韩国庆北大学海外讲师

获奖荣誉：

山东省齐鲁卫生与健康领军人才

山东省优秀医师

山东大学优秀教师

本科生课程：

《口腔正畸学》《口腔医学生的职业素养》

研究生课程：

《当代口腔正畸学》（双语）《方丝弓技术》

1. 81771108，国家自然科学基金面上项目，在改善糖尿病大鼠牙齿正畸效果过程中miR-222参与二甲双胍调控骨细胞的相关机制研究，国家自然科学基金委，2018.01-2021.12，54万元，主持

2. 81970964，国家自然科学基金面上项目，正畸牙齿移动过程中骨膜蛋白和HMGB1相互调控参与牙周组织改建的机制，国家自然科学基金委，2020.01-2023.12，55万元，主持

3. 82370999，国家自然科学基金面上项目，压应力下GPX4介导ITG3-THBS1-RUNX1信号轴调控成骨细胞铁死亡的机制研究，国家自然科学基金委，2024.1-2027.12，48万元，主持

4. 科普项目， “如“齿”闪亮--口腔健康科普示范团队”，项目类别：科普志愿服务团队，山东省科学技术协会，2024.7-2024.11，5万元，主持

5. 82571137，国家自然科学基金面上项目，多模态跨组学解析Integrin αvβ3-JMJD3-SLC7A11轴驱动巨噬细胞表型重编程机制及正畸牙移动安全性预警模型构建，国家自然科学基金委，2026.01-2029.12，49万元，主持

6. ZR2025MS1332，山东省自然科学基金面上项目，多组学解析KDM6B-SLC7A11信号枢纽介导巨噬细胞代谢重塑的分子网络及其在正畸安全预警中的转化，山东省科技厅，2025.7.1-2028.6.30，10万元，主持

1.Wang Y, Zeng Z, Cheng Y, Zhao L, Yan Q, Qiu Y, Hu J*,Guo J*. Orthodontic compressive force modulates Ets-1/Tks5 pathway to promote the formation of circumferential invadopodia and the fusion of osteoclast precursors. J Cell Physiol. 2019 Aug;234(8):12685-12691.

2.Wu Z, Zhang X, Li Z, Liu Y, Jin H, Chen Q,Guo J*. A Bayesian network meta-analysis of orthopaedic treatment in Class III malocclusion: Maxillary protraction with skeletal anchorage or a rapid maxillary expander. Orthod Craniofac Res. 2020 Feb;23(1):1-15.

3.Li D, Kou Y, Gao Y, Liu S, Yang P, Hasegawa T, Su R,Guo J*, Li M*. Oxaliplatin induces the PARP1-mediated parthanatos in oral squamous cell carcinoma by increasing production of ROS. Aging (Albany NY). 2021 Jan 20;13(3):4242-4257.

4.Liu Y, Hou R, Jin H, Zhang X, Wu Z, Li Z,Guo J*. Relative effectiveness of facemask therapy with alternate maxillary expansion and constriction in the early treatment of Class III malocclusion. Am J Orthod Dentofacial Orthop. 2021 Mar;159(3):321-332.

5.Qin Q, Yang H, Zhang C, Han X, Guo J, Fan Z*,Guo J*. lncRNA HHIP-AS1 Promotes the Osteogenic Differentiation Potential and Inhibits the Migration Ability of Periodontal Ligament Stem Cells. Stem Cells Int. 2021 Apr 27;2021:5595580.

6.Jiang Y, Yang P, Li C, Lu Y, Kou Y, Liu H,Guo J*, Li M*: Periostin regulates LPS-induced apoptosis via Nrf2/HO-1 pathway in periodontal ligament fibroblasts. Oral Dis. 2022 Mar 17.

7.Fan Z, Zhang Q, Jiang Y, Qin Q, Huang S, Guo J*. Mandibular retromolar space in adults with different sagittal skeletal patterns. Angle Orthod. 2022 Jul 18;92(5):606–12.

8.Yan S, Huang S, Wu Z, Liu Y, Men Y, Nie X,Guo J*. A CBCT Investigation of the Sella Turcica Dimension and Sella Turcica Bridging in Different Vertical Growth Patterns. J Clin Med. 2023 Feb 27;12(5):1890.

9.Nie X, Zhang X, Liu Y, Yan S, Men Y, Yu J,Guo J*. Evaluation of palate-related factors of the effectiveness of microimplant-assisted rapid palatal expansion in late adolescents and adults. Clin Oral Investig. 2023 Mar 29.

10.Zhang, Y., Jiang, S., Xu, D., Li, Z.,Guo, J*., Li, Z., & Cheng, G. (2023). Application of Nanocellulose-Based Aerogels in Bone Tissue Engineering: Current Trends and Outlooks.Polymers,15(10), 2323.

11.Mengjia W, Jun J, Xin Z, Jiahao Z,Guo J*. GPX4-mediated bone ferroptosis under mechanical stress decreased bone formation via the YAP-TEAD signalling pathway. J Cell Mol Med. 2024 Apr;28(7):e18231.

12.Xiao T, Su JY, Lei J, Zhang X, Yu J, Nie XP, Ying QH, Hou JX,Guo J*. Effectiveness of different intrusion modes of maxillary anterior teeth with mini-implants in clear aligner treatment: a three-dimensional finite element analysis. BMC Oral Health. 2024 Jul 2;24(1):758.

13.Liu, T., Wang, L., Shi, T., Liu, H., Liu, B.,Guo, J.*, & Li, M. (2024). ED-71 Ameliorates Bone Loss in Type 2 Diabetes Mellitus by Enhancing Osteogenesis Through Upregulation of the Circadian Rhythm Coregulator BMAL1. Drug design, development and therapy, 18, 3903–3919.

14.Ying, Q., Jiang, Y., Sun, C., Zhang, Y., Gao, R., Liu, H., Liu, H.,Guo, J.*, & Li, M. (2024). AGEs impair osteogenesis in orthodontic force-induced periodontal ligament stem cells through the KDM6B/Wnt self-reinforcing loop. Stem cell research & therapy, 15(1), 431.

15.Ying, Q., Wang, M., Zhao, Z., Wu, Y., Sun, C., Huang, X., Zhang, X., &Guo, J*. (2024). White Matter Imaging Phenotypes Mediate the Negative Causality of Mitochondrial DNA Copy Number on Sleep Apnea: A Bidirectional Mendelian Randomization Study and Mediation Analysis. Nature and science of sleep, 16, 2045–2061.

16.Liu, H., Sun, C., Jiang, Y., Gao, R., Ying, Q., Li, X., Liu, H.,Guo, J.*, & Li, M. (2025). Eldecalcitol alleviates diabetic periodontitis by regulating macrophage efferocytosis and polarization via SOCE machinery. International immunopharmacology, 146, 113894.

17.Zhang, Y., Cui, Y., Sun, C.,Guo, J.*, & Li, M. (2025). ED-71 ameliorates OVX-induced osteoporosis by regulating calcium homeostasis and SIRT1-mediated mitochondrial function, alleviating osteoblast senescence and suppressing osteoclastogenesis. Cellular signalling, 131, 111713. Advance online publication.

18.Zhang, J., Wang, W., Wang, M., Hai, H., Li, K., Wang, L., Lei, M., Cui, L., Liu, H.,Guo, J.*, & Liu, C. (2025). Piezoelectric-IL-4 programmed regulation of immuno-microenvironment-induced mesenchymal stem cell recruitment and differentiation for bone regeneration. Ultrasonics sonochemistry, 120, 107431. Advance online publication.

19.Liu T, Zhang W, Bao W, Wang X, Zhang F,Guo J*, Li M. Aβ impairs bone vascular homeostasis in APP/PS1 mice via disrupting the mitochondrial fission-efferocytosis axis in macrophages. Int Immunopharmacol. 2025 Sep 10;165:115526.

20.Liu H, Jiang Y, Sun C,Guo J*, Li M. Macrophage Efferocytosis Controls Tissue Repair via Mitochondrial Dynamics in Diabetic Periodontitis. J Periodontal Res. 2025 Sep 15.

21.Wu Y, Zhao Z, Lu J, Ying Q, Huang X, Zhang X, Sun C, Yu J,Guo J*. A personalized automated system of 3D facial soft tissue landmarks annotation based on deep learning and computer vision. BMC Oral Health. 2025 Dec 10.

22.陈磊，郭杰. 错��畸形横向问题的诊断方法. 中华口腔医学杂志，2025，60(12):1344-1352.