学习与工作经历：

2023-06 至今，山东大学，生殖医院、妇儿与生殖健康研究院，副研究员/硕导

2022-01 至 2023-05，山东大学，生殖医院、生殖医学研究中心，副研究员

2012-07 至 2018-08，山东大学，生殖医院，生殖医学研究中心，科研助理

2018-09 至 2021-12，山东大学、基础医学院，细胞生物学专业，博士

2009-09 至 2012-06，南开大学、医学院，生理学专业，硕士

2005-09 至 2009-06，山东大学、生命科学学院，生物科学专业，本科

研究方向：

1. 基础研究：利用分子生物学、细胞生物学、动物模型和多种微量组学技术等研究高等生物配子发生和早期胚胎发育的分子调控机制。科研方向包括PGC和SSC的发育调控机制研究以及减数分裂同源重组调控机制研究，重点关注表观遗传尤其是组蛋白修饰及其识别分子、核心转录因子等在以上发育过程中的动态变化及分子调控机制。

2. 转化及应用研究：无创诊断技术研发及应用，重点关注基于血浆游离DNA和RNA的序列信息及其修饰信息的诊断方法研发及其推广应用。

学术/社会兼职：

中国医师协会医学遗传学分会委员、中国非公立医疗机构协会男性生殖与性医学专业委员会委员、山东省研究型医院协会杰出青年学者分会委员、山东省医学会医学细胞生物学分会科普学组委员、山东省医学会健康教育与健康促进学组委员。

获奖荣誉：

青年泰山学者 2024年

本科生课程：

本科生选修课《发育生物学》

研究生课程：

研究生必修课《妇儿与生殖健康前沿进展》

1. 82371618，ZCWPW2介导减数分裂重组位点处DNA双链断裂的产生及其分子机 制研究，国家自然科学基金面上项目，2024.01-2027.12，49万元，主持

2.精源性疾病的发病机制及防治策略，国家自然科学基金重大项目，2025.01-2028.12，80万，课题骨干

3.2024YFC2706800，父源遗传物质调控机理及其对子代健康的影响，国家重点研发计划，2024.12-2027.11，75万，课题骨干

4.2024YFC2707300，亲代肥胖暴露影响子代发育异常的机制研究，国家重点研发计划，2024.12-2027.11，75万，课题骨干

5. Tsqn202408397,泰山学者（青年专家）项目，2025.01-2027.12, 37.5万，主持

6. 2220023011，胚胎植入前染色体非整倍体检测试剂盒（联合探针锚定聚合测序法）临床试验 ，横向项目，2023.10-2024.10，48万，主持

1.Shiyu Wang^#, Yuling Cai^#, Tongtong Li, Yan Wang, Ziyou Bao, Renxue Wang, Junchao Qin, Ziqi Wang,Yining Liu, Zhaojian Liu, Wai-Yee Chan, Xiangfeng Chen, Gang Lu*, Zi-Jiang Chen*,Tao Huang*, and Hongbin Liu*. CWF19L2 is Essential for Male Fertility and Spermatogenesis by Regulating Alternative Splicing.Advanced Science; 2024 Jun 18: e2403866.(JCR一区，IF16.3.共同通讯作者)

2.Tao Huang^#, Xinyue Wu^#, Shiyu Wang, Ziyou Bao, Yanling Wan, Ziqi Wang, Mengjing Li, Xiaochen Yu, Yue Lv, Zhaojian Liu, Xiangfeng Chen, Wai-Yee Chan, Fei Gao, Gang Lu*, Zi-Jiang Chen*，Hongbin Liu*.SPIDR is Required for Homologous Recombination During Mammalian Meiosis.Nucleic Acids Research; 2023 May 8;51(8):3855-3868.(JCR一区，IF 19.16.第一作者)

3.Shenli Yuan^#,Tao Huang^#*,Ziyou Bao^#,Shiyu Wang^#, Xinyue Wu^#, Jiang Liu*, Hongbin Liu*, Zi-Jiang Chen*. The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots.Genome Biology; 2022 Sep 6;23(1):187.（JCR一区，IF 20.36.共同第一作者和共同通讯作者）

4.Junchao Qin^#,Tao Huang^#, Zixiang Wang^#, Xiyu Zhang, Jing Wang, Qianli Dang, Donghai Cui, Xinyu Wang, Yunjiao Zhai, Ling Zhao, Gang Lu, Changshun Shao, Shiyang Li, Hongbin Liu*, Zhaojian Liu*.Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation.Cell Death and Differentiation; 2023 Jan;30(1):184-194.(JCR一区，IF 12.89.共同第一作者)

5.Shixiong Tian^#, Ziqi Wang^#, Liting Liu^#, Yiling Zhou, Yue Lv, Dongdong Tang, Jiaxiong Wang, Jing Jiang, Huan Wu, Shuyan Tang, Guanxiong Wang, Hao Geng, Fangbiao Tao, Hongbin Liu, Xiaojin He, Feng Zhang, Jinsong Li, Li Jin,Tao Huang*, Chunyu Liu*, Yunxia Cao*. A homozygous frameshift mutation in ADAD2 cause male infertility with spermatogenic impairments.Journal of Genetics and Genomics; 2023 Jan 3; S1673-8527(22)00284-3.(JCR一区，IF 5.75.共同通讯作者)

6.Tao Huang^#, Shenli Yuan^#, Lei Gao, Mengjing Li, Xiaochen Yu, Jianhong Zhan, Yingying Yin, Chao Liu, Chuanxin Zhang, Gang Lu, Wei Li, Jiang Liu*, Zi-Jiang Chen*, and Hongbin Liu*. The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair.eLife; Vol.9;2020; e53459.(JCR一区，IF 9.05.第一作者)

7.Tao Huang^#,YingyingYin^#, ChaoLiu, MengjingLi, XiaochenYu, XiugeWang, HaoboZhang, Tahir Muhammad, FeiGao, WeiLi, Zi-JiangChen*, HongbinLiu*, JinlongMa*. Absence of murine CFAP61 causes male infertility due to multiple morphological abnormalities of the flagella.Science Bulletin; Vol.65(10);2020;854-864.(JCR一区，IF11.78.第一作者)

8.Yongliang Shang^#,Tao Huang^#, Hongbin Liu, Yanlei Liu, Heng Liang, Xiaoxia Yu, Mengjing Li, Binyuan Zhai, Xiao Yang, Yudong Wei, Guoqiang Wang, Zijiang Chen*, Shunxin Wang*, Liangran Zhang*.MEIOK21: a new component of meiotic recombination bridges required for spermatogenesis.Nucleic Acids Research; Vol.48(12);2020;6624-663.(JCR一区，IF 15.54.共同第一作者)

9.Miao Li^#,Tao Huang^#, Meng-Jing Li^#, Chuan-Xin Zhang^#, Xiao-Chen Yu, Ying-Ying Yin, Chao Liu, Xin Wang, Hai-Wei Feng, Tuo Zhang, Mo-Fang Liu, Chun-Sheng Han, Gang Lu, Wei Li, Jin-Long Ma, Zi-Jiang Chen, Hong-Bin Liu*,Kui Liu*. The histone modification reader ZCWPW1 is required for meiosis prophase I in male but not in female mice.Science Advances; Vol.5, no.8;2019; eaax1101.(JCR一区，IF 14.09.共同第一作者)

10.Hongbin Liu^#,Tao Huang^#,Mengjing Li^#, Miao Li, Chuanxin Zhang, Jing Jiang, Xiaochen Yu, Yingying Yin, Fan Zhang, Gang Lu, Meng-Cheng Luo, Liang-Ran Zhang, Jinsong Li, Kui Liu*, Zi-Jiang Chen*. SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis.Nucleic Acids Research; Vol.47(11);2019;5670-5683.(JCR一区，IF 11.79.共同第一作者)

11.Yining Liu, Tongtong Li, Mingze Shi, Yanling Wan, Hanzhen Li, Mingyu Zhang, Ziqi Wang, Shiyu Wang, Yue Lv, Gang Lu, Hongbin Liu, Haobo Zhang*,Tao Huang*. MORN2 regulates the morphology and energy metabolism of mitochondria and is required for male fertility in mice.J Transl Med, 2024. 2024 Mar 5;22(1):240.(JCR一区，IF 7.4.最后通讯作者)

12.Ziqi Wang, Tongtong Li, Dongkai Liu, Mengjing Li, Shangming Liu, Xiaochen Yu, Hanzhen Li, Hui Song, Wei Zhao, Zhaojian Liu, Xiangfeng Chen, Yuan Gao, Zi-Jiang Chen*,Tao Huang*, Hongbin Liu*. The deubiquitinase cofactor UAF1 interacts with USP1 and plays an essential role in spermiogenesis.iScience, 2024 Mar 11;27(4):109456.(JCR一区，IF 5.8.共同通讯作者)

13.Yingying Yin, Wenyu Mu, Xiaochen Yu, Ziqi Wang, Ke Xu, Xinyue Wu, Yuling Cai, Mingyu Zhang, Gang Lu, Wai-Yee Chan, Jinlong Ma,Tao Huang*, Hongbin Liu*.LRRC46 Accumulates at the Midpiece of Sperm Flagella and Is Essential for Spermiogenesis and Male Fertility in Mouse.International Journal of Molecular Sciences; 2022 Jul 31;23(15):8525.(JCR二区，IF 6.62.共同通讯作者)

14.Ziqi Wang^#, Kailun Fang, Yanling Wan, Yingying Yin, Mengjing Li, Ke Xu, Tongtong Li, Yongzhi Cao, Yue Lv, Gang Lu, Hongbin Liu,Tao Huang*.TTC6-Mediated Stabilization of the Flagellum Annulus Ensures the Rapid and Directed Motion of Sperm.Cells; 2023 Aug 18;12(16):2091.(JCR二区，IF 6.7.唯一通讯作者)

15.Junchao Qin,Tao Huang, Jing Wang, Limei Xu, Qianli Dang, Xiuhua Xu, Hongbin Liu, Zhaojian Liu, Changshun Shao, Xiyu Zhang. RAD51 is essential for spermatogenesis and male fertility in mice.Cell Death Discovery; Vol.8(1);2022;118.（JCR二区，IF5.302，第二位）