学习与工作经历：

研究员（Professor） 

2019年2月–至今   山东大学附属生殖医院/医学融合与实践中心                                            

哈佛大学医学院博士后（Postdoctoral Fellow）

2016年7月–2019年2月  美国布莱根妇女医院（BWH）Channing Lab

妇产科生殖内分泌专业研究型博士（Ph.D）       

2011年9月–2015年9月  加拿大英属哥伦比亚大学 （UBC）

妇产科临床医学七年制本硕连读 (M.D)                 

2004年9月–2011年6月    山东大学（SDU）

研究方向：

围绕母胎界面建立和维持调控机制，开展子痫前期、复发性流产等的发病机理及临床诊疗研究，研究方向涉及滋养细胞分化、子宫内膜蜕膜化、母胎界面免疫调控、细胞信号通路、糖代谢、妊娠相关疾病临床诊疗标志物筛查和鉴定。

学术/社会兼职：

国际期刊Front Cell Dev Biol、Biochemistry and Molecular Biology编委；

国际SCI期刊BMC Medicine、Science China Life Sciences、Frontiers in Immunology等20余个SCI期刊审稿人；

2021-2023年美国ENDO年会摘要审稿专家；

获奖荣誉：

山东医学科技奖一等奖（2/7）                  2021年

山东大学未来计划青年学者                    2020年

YW Loke新研究学者奖（国际 IFPA年会，加拿大惠斯勒）  2013年

山东省级优秀毕业生                        2011年 

本科生课程：

妇产科学（必修）、生殖健康与奥秘（选修）

研究生课程：

生殖医院专硕课程

1. 2022YFC2702400，胎盘发育和功能的调节机制，国家重点研发计划，2022-12至2025-11，1000万，科研骨干（54万元）；

2. 82101784，BMP6调控滋养细胞侵袭在子痫前期发病中的作用及机制，国家自然科学基金青年项目， 2022-2024，30万，主持；

3. 2022KJ014，山东省高等学校“青创团队计划”，生殖医学创新团队，山东省教育厅，2022-12至2025-11，15.85万，团队带头人；

4. BK20200223，激活素A促进EVT侵袭力在子痫前期中的作用机制研究，江苏省自然科学基金青年项目，2020-2023， 20万，主持；

5. ZR2020QH051，WNT5A介导BMP2调控滋养细胞侵袭的机制研究及其表达异常与子痫前期病理发生的关系，山东省自然科学基金青年项目，2021-2023，14万，主持；

6. 子痫前期的病因机制和早期诊疗研究，山东大学青年学者未来计划，2020-2025，50万，主持；

7. 转化生长因子-β（TGF-β）家族成员在促进人类绒毛外滋养细胞侵袭力中的作用机制研究，山东大学基本科研业务费，2019-2021，20万，主持；

8. 激活素A促进人类绒毛外滋养细胞侵袭力中的作用机制研究，山东大学齐鲁医学院科研启动基金2019-2021，20万，主持；

9. 2021LCZX02，反复早期妊娠丢失高危因素预测及临床精准治疗关键技术研发与临床应用，山东省重点研发计划（重大科技创新工程），2021-12至2024-12，198万元，骨干研究人员。

1.Jianye Deng^#, Hong-Jin Zhao^#, Ying Zhong^#, Cuiping Hu, Jinlai Meng, Chunling Wang, Xiangxin Lan, Xiyao Wang, Zi-Jiang Chen, Junhao Yan*, Wei Wang*,Yan Li*.H3K27me3-modulated Hofbauer cell BMP2 signalling enhancement compensates for shallow trophoblast invasion in preeclampsia.EBioMedicine.2023 Jul;93:104664. doi: 10.1016/j.ebiom.2023.104664.

2.Chunzi Lyu, Tianxiang Ni, Yaqiu Guo, Tingting Zhou, Zi-Jiang Chen, Junhao Yan*,Yan Li*.Insufficient GDF15 expression predisposes women tounexplained recurrent pregnancy loss by impairingextravillous trophoblast invasion.Cell Proliferation.2023 Jun 4:e13514. doi: 10.1111/cpr.13514.

3.Yan Li^#,Junhao Yan^#, Hsun-Ming Chang, Zi-Jiang Chen*, Peter C.K. Leung*. Roles of TGF-β superfamily proteins in extravillous trophoblast invasion.Trends in Endocrinology & Metabolism.2021 Mar;32(3):170-189.(封面文章)

4.Mingxi Liu#, Yue Niu#, Kongyang Ma#, Peter C. K. Leung, Zi‑Jiang Chen, Daimin Wei*,Yan Li*. Identification of novel first-trimester serum biomarkers for early prediction of preeclampsia.J Transl Med. 2023 Sep 18;21(1):634. doi: 10.1186/s12967-023-04472-1.

5.Xiyao Wang^#, Wenqiang Shi^#, Shaotong Zhao, Deshun Gong, Shuo Li, Cuiping Hu, Zi-Jiang Chen,Yan Li*, Junhao Yan*.Whole exome sequencing in unexplained recurrent miscarriage families identified novel pathogenic genetic causes of euploid miscarriage.Human Reproduction.2023 May 2;38(5):1003-1018. doi: 10.1093/humrep/dead039.

6.Zhaowen Zang, Min Hu, Yueyue Yan, Yaxin Su, Junhao Yan, Zi-Jiang Chen,Yan Li. Pregnancy and neonatal outcomes in infertile patients with positive tuberculin skin test results.Reprod Biomed Online. 2023 Jul 28;47(5):103307. doi: 10.1016/j.rbmo.2023.103307.

7.Ling Guo, Xiyao Wang, Yufeng Wang, Fengxuan Sun, Yifei Song, Caiyi Chen, Junhao Yan,Yan Li.Impact of thyroid autoimmunity on pregnancy outcomes in euthyroid patients with recurrent implantation failure.Reprod Biomed Online.2023 Sep;47(3):103229. doi: 10.1016/j.rbmo.2023.05.001.

8.Ling Guo^#, Xiangxin Lan^#, Shanshan Liu^#, Lianqiong Xu, Shiqin Zhu, Hong-Jin Zhao, Jinlai Meng*,Yan Li*. Distinct cytokine profiles in patients with preeclampsia.Inflammation Research. 2023 Apr;72(4):847-858. doi: 10.1007/s00011-023-01709-z.

9.Yan Li^#, Yue Niu^#, Mingxi Liu, Xiangxin Lan, Rencai Qin, Kongyang Ma, Hong-Jin Zhao*. First-trimester serum antiphosphatidylserine antibodies serve as candidate biomarkers for predicting pregnancy-induced hypertension.Journal of Hypertension. 2023 Sep 1;41(9):1474-1484. doi: 10.1097/HJH.0000000000003498

10.Yue Niu, Lu Suo, Dingying Zhao, Yuhuan Wang, Ruolan Miao, Jialin Zou, Xinwei Han, Zi‑Jiang Chen,Yan Li*, Daimin Wei*.Is artifcial endometrial preparation more associated with early‑onset or late‑onset preeclampsia after frozen embryo transfer?J Assist Reprod Genet.2023 Mar 31. doi: 10.1007/s10815-023-02785-0.

11.Fengxuan Sun, Lei Cheng, Ling Guo, Shizhen Su,Yan Li*, Junhao Yan*.Activin A promotes human trophoblast invasion by upregulating integrin β3 via ALK4-SMAD4 signaling.Placenta. 2022 Nov;129:62-69.doi: 10.1016/j.placenta.2022.10.004.

12.Xiangxin Lan^#, Ling Guo^#, Shiqin Zhu^#, Yongzhi Cao, Yue Niu, Shuwen Han, Zeyan Li,Yan Li*, Junhao Yan*. First-Trimester Serum Cytokine Profile in Pregnancies Conceived After Assisted Reproductive Technology (ART) With Subsequent Pregnancy-Induced Hypertension.Front Immunol. 2022 Jul 1;13:930582. doi: 10.3389/fimmu.2022.930582.

13.Ling Guo^#, Anliang Guo^#, Fang Yang, Li Li, Junhao Yan, Xiaohui Deng, Caifeng Dai*,Yan Li*. Alterations of Cytokine Profiles in Patients With Recurrent Implantation Failure.Front Endocrinol (Lausanne).2022 Jul 11;13:949123. doi: 10.3389/fendo.2022.949123.

14.Hong-Jin Zhao^#*,Yan Li^#, De-Yu Wang, Hai-Tao Yuan*. ARB might be superior to ACEI for treatment of hypertensive COVID-19 patients.J Cell Mol Med. 2021 Dec;25(23):11031-11034.

15.Shiqin Zhu, Zeyan Li, Cuiping Hu, Fengxuan Sun, Chunling Wang, Haitao Yuan*,Yan Li*. Imaging-Based Body Fat Distribution in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.Frontiers in Endocrinology.2021 Sep 9;12:697223. doi: 10.3389/fendo.2021.697223.

16.Yan Li*, Li Zhang, Francesca Polverino, Feng Guo, Yuan Hao, Taotao Lao,Shuang Xu, Lijia Li, Betty Pham, Caroline A. Owen,Xiaobo Zhou*.Hedgehog interacting protein (HHIP) represses airway remodeling and metabolic reprogramming in COPD-derived airway smooth muscle cells.Scientific Reports. 2021 Apr 27;11(1):9074.

17.Shiqin Zhu, Zeyan Li, Linlin Cui, Yanli Ban, Peter C.K. Leung,Yan Li*, Jinlong Ma*.Activin A increases human trophoblast invasion by up-regulating integrinβ1 through ALK4.The FASEB Journal. 2021 Feb;35(2):e21220. doi: 10.1096/fj.202001604R.

18.Hong-Jin Zhao, Christian Klausen, Hua Zhu, Hsun-Ming Chang,Yan Li*, Peter C.K. Leung*.Bone morphogenetic protein 2 promotes human trophoblast cell invasion and endothelial-like tube formation through ID1-mediated up-regulation of IGF binding protein-3.The FASEB Journal.2020 Feb;34(2):3151-3164.

19.Hong-Jin Zhao, Hsun-Ming Chang, Christian Klausen, Hua Zhu,Yan Li*, Peter C.K. Leung*.Bone morphogenetic protein 2 induces the activation of WNT/β-catenin signaling and human trophoblast invasion through up-regulating BAMBI.Cellular Signalling.2020 Mar;67:109489.

20.Hong-Jin Zhao, Xiao-Mei Yang, Ai-Hong Wang*,Yan Li*.Pharmacological Rationale for Antihypertensive Drug Choice on COVID-19 Affected Patients: ACEI/ARB might not increase their susceptibility.J Cell Mol Med. 2020 Sep 17;doi: 10.1111/jcmm.15850

21.Yan Li,Michael H. Cho, Xiaobo Zhou*.What do polymorphisms tell us about the mechanisms of COPD?Clinical Science.2017 Dec 4;131(24):2847-2863. doi: 10.1042/CS20160718.

22.Hongjin Zhao^#,Yan Li^#, Shanmei Liu, Xiangguo Sun, Min Li, Yan Hao, Lianqun Cui*, Aihong Wang*. (2016)Effect of calcium channels blockers and inhibitors of the renin-angiotensin system on renal outcomes and mortality in patients suffering from chronic kidney disease: systematic review and meta-analysis.Renal Failure.2016 Jul;38(6):849-56. doi: 10.3109/0886022X.2016.1165065.

23.Yan Li, Christian Klausen,HuaZhu,Peter C.K. Leung*.(2015)Activin A increases human trophoblast invasion by inducingSNAIL-mediated MMP2 up-regulation through ALK4.J Clin Endocrinol Metab.2015 Nov;100(11):E1415-27. doi: 10.1210/jc.2015-2134.

24.Yan Li, HuaZhu, Christian Klausen,Bo Peng, Peter C.K. Leung*.Vascular endothelial growth factor-A(VEGF-A) mediates activin A-induced human trophoblastendothelial-like tube formation.Endocrinology. 2015 Nov;156(11):4257-68. doi: 10.1210/en.2015-1228.

25.Yan Li, Christian Klausen, Jung-Chien Cheng, Hua Zhu, Peter C.K. Leung*. Activin A, B and AB increase human trophoblast cell invasion by up-regulating N-cadherin.J Clin Endocrinol Metab.2014 Nov;99(11):E2216-25. doi: 10.1210/jc.2014-2118.

26.Yan Li^#, Hongjin Zhao^#, Li Sun, Linjuan Huang, Qifeng Yang*, Beihua Kong*.MDM2 SNP309 Is Associated with Endometrial Cancer Susceptibility: a meta-analysis.HumanCell.2011Jun;24(2):57-64.doi:10.1007/s13577-011-0013-4.