学习与工作经历：

1996.9-2001.7 济宁医学院 本科 学士

2001.9-2006.6 山东大学 博士研究生

2006.7-2013.4 山东省立医院  主治医师

2013.4-2017.12 山东省立医院 副主任医师

2017.12-2020.12 山东省耳鼻喉医院   副主任医师

2020.12-2023.8  山东省第二人民医院（山东省耳鼻喉医院）   主任医师

2023.8-至今    山东省第二人民医院（山东省耳鼻喉医院） 副院长，主任医师 

研究方向：

耳科学、眩晕与前庭疾病基础与临床研究

学术/社会兼职：

中华医学会耳鼻咽喉头颈外科分会第十三届委员会耳科学组委员

中国研究型医院学会眩晕医学专业委员会副主任委员

中国中西医结合学会第二届眩晕病专业委员会副主任委员

中国医疗保健国际交流促进会眩晕医学分会第三届委员会副主任委员

山东省医师协会眩晕病诊疗专业委员会第一届委员会主任委员

获奖荣誉：

2020.2 齐鲁卫生与健康领军人才

2021.4 山东省就业创业工作先进个人

2021.8 2021年度山东好医生

2019.11 敬佑生命·荣耀医者——青年创新奖

本科生课程：

耳鼻咽喉科学

研究生课程：

耳鼻咽喉科学

82471175 IL-1β介导的谷氨酸通路在梅尼埃病中的作用及机制研究 国家自然基金委 2025.01- 2028.12 68万 负责人

82171150 PARP-1介导的Treg细胞调控在梅尼埃病中的作用及机制研究 国家自然基金委 2022.01- 2025.12 57万 负责人

山东省域重点疾病诊疗能力提升项目（眩晕疾病诊疗项目） 山东省卫生健康委员会 2022.1- 2025.12 400万 负责人

81200744 PARP-1介导的AIF通路在链霉素致内耳毛细胞凋亡中的作用及机制研究 国家自然基金委 2013.1- 2015.12 23万 负责人

ZR2024MH027 FXYD3在小鼠内淋巴积水中的作用机制研究 山东省自然科学基金委 2025.1- 2027.12 10万 负责人

ZR2020MH179 SLC4A1在小鼠膜迷路积水中的作用与机制研究 山东省自然科学基金委 2021.1- 2023.12 10万 负责人

2018GSF121027 半规管阻塞术治疗  梅尼埃病的机理研究 山东省科技厅 2018.1- 2020.12 15万 负责人

2011GGH21839 AIF在药物性前庭损伤致毛细胞凋亡中的作用及机制研究 山东省科技厅 2011.1- 2012.12 6万 负责人

Zhang DG, Yu WQ, Liu JH, Kong LG, Zhang N, Song YD, Li XF, Fan ZM, Lyu YF, Li N, Wang HB.（并列第一）Serum/glucocorticoid-inducible kinase 1 deficiency induces NLRP3 inflammasome activation and autoinflammation of macrophages in a murine endolymphatic hydrops model.Nat Commun.2023 Mar 6;14(1):1249.

Bi X, Zhou J, Li P, Song Y, Liu Z, Si N, Shen S, Li W, Wu Y, Zhao X, Hong G, Zhang Y, Guo S, Xiao Y, Zhao M, Yu Y, Xia M, Zhang H,Zhang D, Fu X.（并列通讯）Inhibiting ferroptosis in type I hair cells of the utricle might be a promising strategy for treating cisplatin-induced vestibulotoxicity.Mol Ther. 2025 Oct 16:S1525-0016(25)00853-6.

Zheng L, Shen Q, Zhao T, Liu Q, Huang Z, Zhao F, Zhang M, Song Y,Zhang D, Liu D, Chen F.（并列通讯）A Novel Functional Method of Protector Screening for Zebrafish Lateral Line Hair Cells via the Acoustic Escape Response.Neurosci Bull.2025 Sep;41(9):1537-1552.

Zhang N, Song Y, Wang H, Li X, Lyu Y, Liu J, Mu Y, Wang Y, Lu Y, Li G, Fan Z, Wang H,Zhang D, Li N.（并列通讯）IL-1β promotes glutamate excitotoxicity: indications for the link between inflammatory and synaptic vesicle cycle in Ménière's disease.Cell Death Discov. 2024 Nov 20;10(1):476.

Li X,Zhang D, Xu L, Han Y, Liu W, Li W, Fan Z, Costanzo RM, Strauss Iii JF, Zhang Z, Wang H.（并列第一作者）Planar cell polarity defects and hearing loss in sperm-associated antigen 6 ( Spag6)-deficient mice.Am J Physiol Cell Physiol. 2021320(1):C132-C141.

Zhang N, Li N, Wang S, Xu W, Liu J, Lyu Y, Li X, Song Y, Kong L, Liu Y, Guo J, Fan Z,Zhang D, Wang H.（并列通讯作者）Protective effect of anakinra on audiovestibular function in a murine model of endolymphatic hydrops.Front Cell Neurosci.202216;1088099.

Zhang D, Lv Y, Li X, Li Y, Song Y, Fan Z, Wang HLong-term efficacy of triple semicircular canal plugging in the treatment of patients with ipsilateral delayed endolymphatic hydrops.Sci Rep.202111(1):3156.

Zhang D, Lv Y, Han Y, Sun G, Li Y, Li X, Sun L, Gong R, Fan Z, Wang H.Revision surgery after triple semicircular canal plugging and morphologic changes of vestibular organ.Sci Rep. 201918;9(1):19397.

Zhang D, Lv Y, Li X, Li Y, Song Y, Fan Z, Wang HLong-term efficacy of triple semicircular canal plugging in the treatment of patients with ipsilateral delayed endolymphatic hydrops.Sci Rep.202111(1):3156.

Zhang D, Lv Y, Han Y, Sun G, Li Y, Li X, Sun L, Gong R, Fan Z, Wang H.Revision surgery after triple semicircular canal plugging and morphologic changes of vestibular organ.Sci Rep. 201918;9(1):19397.

Zhang N, Lyu Y, Guo J, Liu J, Song Y, Fan Z, Li X, Li N,Zhang D, Wang H.（并列通讯作者）Bidirectional Transport of IgE by CD23 in the Inner Ear of Patients with Meniere's Disease.J Immunol.2022208(4):827-838 .

Zhang D, Lv Y, Han Y, Li Y, Li X, Wang J, Song Y, Kong L, Jian H, Fan Z, Wang H.Long-term outcomes of triple semicircular canal plugging for the treatment of intractable Meniere's disease: A single center experience of 361 cases.J Vestib Res. 202029(6):315-322.

Li X,Zhang D, Xu L, Liu W, Zhang N, Strauss JF 3rd, Zhang Z, Wang H.（并列第一作者）Sperm-associated antigen 6 (Spag6) mutation leads to vestibular dysfunction in mice.J Pharmacol Sci.2021147(4):325-330.

Xiong W, Dai Q, Wang Y, Hou Z, Lu K, Sun X, Duan F, Wang H,Zhang D, Wang M.（并列通讯作者）Idiopathic Sudden Sensorineural Hearing Loss in Different Ages: Prognosis of Patients With Initial Total Hearing Loss.Front Psychol.202213;818967.

Lyu Y, Guo J, Li X, Jian H, Li Y, Wang J, Fan Z, Wang H,Zhang D.（通讯作者）Long-term efficacy of dexamethasone treatment via tympanic antrum catheterization for intractable Meniere's disease.Front Neurol.202213:1056724.

Li X, Liu Y, Lyu Y, Li Y, Jian H, Li X, Fan Z, Wang H,Zhang D. （通讯作者）Sensory organization of balance control in children with vestibular migraine and recurrent vertigo of childhood.Front Neurol.20228;13:9706.

Zhang D, Lv Y, Li X, Song Y, Kong L, Fan Z, Wang H.Efficacy of Resection of Lateral Wall of Endolymphatic Sac for Treatment of Meniere's Disease.Front Neurol.2022 13:827462.

Wang R,ZhangD, Luo J, Chao X, Xu J, Liu X, Fan Z, Wang H, Xu L.（并列第一作者）Influence of Cochlear Implantation on Vestibular Function in Children With an Enlarged Vestibular Aqueduct.Front Neurol.202112:663123.

Chen D,Zhang D, Xu L, Han Y, Wang H.（并列第一作者）The alterations of matrix metalloproteinase-9 in mouse brainstem during herpes simplex virus type 1-induced facial palsy.J Mol Neurosci.201330(6):736-740.

Zhang D, Lyu Y, Fan Z, Wang H.Vestibule Plugging for Patient with Isolated Otolith Dysfunction: A Case Report.Laryngoscope.2023133：1734–1736.

Jian H, Wang S, Li X, Zhao H, Liu S, Lyu Y, Fan Z, Wang H,Zhang D.（通讯作者）Effect of Late-Stage Meniere's Disease and Vestibular Functional Impairment on Hippocampal Atrophy.Laryngoscope. 2024 Jan;134(1):410-418.

Li X, Lyu Y, Li Y, Jian H, Wang J, Song Y, Kong L, Fan Z, Wang H,Zhang D（通讯作者）Triple Semicircular Canal Plugging versus Labyrinthectomy for Meniere Disease: A Retrospective Study.Laryngoscope.2023133(11):3178-3184.

Li Y, Lv Y, Hu N, Li X, Wang H,Zhang D.（通讯作者）Imaging Analysis of Patients With Meniere's Disease Treated With Endolymphatic Sac-Mastoid Shunt Surgery.Front Surg. 2022 12;8:673323.

Li X, Lv Y, Wang R, Chao X, Fan Z, Wang H,Zhang D.（通讯作者）Intraoperative auditory brainstem response monitoring during semicircular canal plugging surgery in treatment of Meniere's disease.Acta Otolaryngol.2021141(1):73-77.

Lyu Y,Zhang D, Li X, Han Y, Li Y, Wang J, Song Y, Kong L, Jian H, Fan Z, Wang H.（并列第一作者）Dexamethasone protects the hearing of Meniere's disease patients after triple semicircular canal plugging.Acta Otolaryngol.2020140(10):803-807.

Zhang D, Fan Z, Han Y, Lv Y, Li Y, Wang HTriple semicircular canal plugging: a novel modality for the treatment of intractable Meniere's disease.Acta Otolaryngol.2016 136(12):1230-1235.

Song Y, Fan Z, Bai X, Liu W, Han Y, Xu L, Wang M, Li J, Zheng Q,Zhang D, Wang H.（并列通讯作者）PARP-1-modulated AIF translocation is involved in streptomycin-induced cochlear hair cell death.Acta Otolaryngol.2016136(6):545-50.

【中文系列】

张道宫，史宏璐，樊兆民，王光彬，韩月臣，李亚伟，王海波.经鼓室钆注射内耳成像磁共振检查在梅尼埃病中的应用.中华耳鼻咽喉头颈外科杂志.201348(8):628-633.

李霄飞，李兵，吕亚峰， 菅慧蓉， 李亚伟， 樊兆民， 张道宫，王海波（并列通讯作者）健康人群脉冲-阶跃-正弦试验结果的初步分析.中华耳鼻咽喉头颈外科杂志.202257(6):671-676.

菅慧蓉，胡娜，李霄飞，吕亚峰，李亚伟，樊兆民，王海波，张道宫.（通讯作者）前庭神经炎患者内耳3D-FLAIR MRI特点与前庭功能相关性分析.中华耳鼻咽喉头颈外科杂志.202257(5):578-583.

张道宫，徐磊，韩月臣,吕亚峰，罗建芬，李亚伟，王睿婕，樊兆民，王海波.半规管阻塞术联合人工耳蜗植入治疗晚期梅尼埃病疗效分析.中华耳鼻咽喉头颈外科杂志. 201752(1):25-30.

张道宫，樊兆民，韩月臣，李亚伟，王海波.内淋巴囊乳突引流术治疗梅尼埃病疗效分析.中华耳鼻咽喉头颈外科杂志.201550(9):729-732.