1.Zhao Wang; Shawn Rumrill; Dongwei Kang; Samuel Desta Guma; Da Feng; Erik De Clercq; Christophe Pannecouque; Chin Ho Chen; Eddy Arnold; Francesc Xavier Ruiz; Xinyong Liu; Peng Zhan. Development of enhanced HIV-1 non-nucleoside reverse transcriptase inhibitors with improved resistance and pharmacokinetic profiles.Science Advances. 2025, 11(22): eadt8916.
2.Zhao Wang; Heng Zhang; Zhen Gao; Zihao Sang; Erik De Clercq; Christophe Pannecouque; Dongwei Kang; Peng Zhan; Xinyong Liu. Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants.Acta Pharmaceutica Sinica B. 2024, 14(3): 1257-1282.
3.Zhao Wang; Prem Prakash Sharma; Brijesh Rathi; Minghui Xie; Erik De Clercq; Christophe Pannecouque; Dongwei Kang; Peng Zhan; Xinyong Liu. Escaping from flatland: multiparameter optimization leads to the discovery of novel tetrahydropyrido[4,3-d]pyrimidine derivatives as human immunodeficiency virus-1 non-nucleoside reverse transcriptase inhibitors with superior antiviral activities against non-nucleoside reverse transcriptase inhibitor-resistant variants and favorable drug-like profiles.Journal of Medicinal Chemistry. 2023, 66(13): 8643-8665.(封面文章)
4.Zhao Wang; Srinivasulu Cherukupalli; Minghui Xie; Wenbo Wang; Xiangyi Jiang; Ruifang Jia; Christophe Pannecouque; Erik De Clercq; Dongwei Kang; Peng Zhan; Xinyong Liu. Contemporary medicinal chemistry strategies for the discovery and development of novel HIV-1 non-nucleoside reverse transcriptase inhibitors.Journal of Medicinal Chemistry. 2022, 65(5): 3729-3757.
5.Zhao Wang; Waleed A. Zalloum; Wenbo Wang; Xiangyi Jiang; Erik De Clercq; Christophe Pannecouque; Dongwei Kang; Peng Zhan; Xinyong Liu. Discovery of novel dihydrothiopyrano[4,3-d]pyrimidine derivatives as potent HIV-1 NNRTIs with significantly reduced hERG inhibitory activity and improved resistance profiles.Journal of Medicinal Chemistry. 2021, 64(18): 13658-13675.(封面文章)
6. Xiangkai Ji; Xiangyi Jiang; Zhen Gao; Heng Gao; Xing Huang; Fabao Zhao; Erik De Clercq;Zhao Wang*; Christophe Pannecouque; Dongwei Kang; Peng Zhan; Xinyong Liu. Exploring the HIV-1 reverse transcriptase p51/p66 interface: structure-based design and optimization of novel 2,4,6-trisubstituted pyrimidines as potent NNRTIs with improved resistance profiles.Journal of Medicinal Chemistry. 2025, 68(19): 20519-20535.
7.Zhao Wang; Wenbo Wang; Zhen Gao; Huizhan Gao; Erik De Clercq; Christophe Pannecouque; Chin-Ho Chen; Dongwei Kang; Peng Zhan; Xinyong Liu. Structure-based design, synthesis, and biological characterization of indolylarylsulfone derivatives as novel human immunodeficiency virus type 1 inhibitors with potent antiviral activities and favorable drug-like profiles.Journal of Medical Virology. 2024, 96(8): e29830.
8.Zhao Wang; Dongwei Kang; Da Feng; Srinivasulu Cherukupalli; Xiangyi Jiang; Zhipeng Fu; Erik De Clercq; Christophe Pannecouque; Xinyong Liu; Peng Zhan. Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility.European Journal of Medicinal Chemistry. 2020, 206: 112811.
9. Minghui Xie;Zhao Wang*; Fabao Zhao; Ye Li; Zongji Zhuo; Xin Li; Erik De Clercq; Christophe Pannecouque; Peng Zhan; Xinyong Liu; Dongwei Kang. Structure-based design of diarylpyrimidines and triarylpyrimidines as potent HIV-1 NNRTIs with improved metabolic stability and drug resistance profiles.Journal of Medical Virology. 2024, 96(3): e29502.(主编推荐)
10.Zhao Wang; Zhao Yu; Dongwei Kang; Jian Zhang; Ye Tian; Dirk Daelemans; Erik De Clercq; Christophe Pannecouque; Peng Zhan; Xinyong Liu. Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs.Bioorganic & Medicinal Chemistry. 2019, 27(3): 447-456.(封面文章)
