学习与工作经历：

1992年获得山东医科大学临床医学学士学位

2002年获得山东大学临床医学硕士学位

2012年获得山东大学临床医学博士学位

1992年至1996年在齐鲁医院胸外科工作

1997年至今在山东大学第二医院胸外科工作，教授/博导

其中2013.01-2023.07,山东大学第二医院副院长

2023.02至今,山东大学第二医院胸外科主任

研究方向：

胸部肿瘤（肺癌/食管癌）发生发展机制研究、早期诊断标志物发现及药物治疗靶点筛选

学术/社会兼职：

国家临床重点专科和山东省临床重点专科（胸外科）学科带头人、山东省临床精品特色专科（肺部疾病精准诊疗）学科带头人、山东省胸部肿瘤精准诊疗工程实验室主任、山东省高等学校胸部肿瘤基础研究与临床转化重点实验室、山东省高校“十三五”重点实验室（胸部肿瘤实验室）主任、山东大学胸部疾病研究中心主任、济南市胸部肿瘤临床医学研究中心主任。国家科技奖、国家自然科学基金及国家重点研发计划评审专家。

获奖荣誉：

泰山学者特聘专家，山东省有突出贡献的中青年专家，山东省齐鲁卫生与健康领军人才，山东大学齐鲁医学院杰出医学专家，山东大学先进教育工作者，山东大学“我心目中的好导师”。研究成果曾获山东省科技进步一等奖和教育部优秀科研成果二等奖。

本科生课程：

外科学、临床疾病研究概论

研究生课程：

1. 肺癌多学科精准诊疗   国家卫生健康委  2020-2024   500万    负责人

2. 81874396 雷公藤甲素逆转肺腺癌紫杉醇耐药作用特征及靶点网络构建  国自然基金委   2019-2022   61万     负责人

3. ZR2018ZC0232超声/氧化还原双重靶向肺部肿瘤细胞的硫酸软骨素纳米载体构建与体内外生物学评价  山东省科技厅   2019-2021   100万     负责人

4. 2020CXGC011303基于高通量测序的食管癌精准诊疗模型的构建及产业化应用   山东省科技厅  2020-2023    100万    负责人

1. Xue X, Zhang Y, Liao Y, Sun D, Li L, Liu Y, Wang Y, Jiang W, Zhang J, Luan Y,Zhao X^*. Design, synthesis and biological evaluation of dual HDAC and VEGFR inhibitors as multitargeted anticancer agents. 2022;40(1):10-20.

2. Zhao Y, Wang Y, Shan L, Peng C, Zhang W,Zhao X^*. A network meta-analysis for neoadjuvant and adjuvant treatments for resectable squamous cell carcinoma of esophagus. Biomaterials science. 2021;11(1):6800.

3. Zhao Y, Shan L, Peng C, Cong B,Zhao X^*. Learning curve for minimally invasive oesophagectomy of oesophageal cancer and survival analysis. Investigational new drugs. 2021;16(1):328.

4. Zhang Y, Qiu N, Zhang Y, Yan H, Ji J, Xi Y, Yang X^*,Zhao X^*, Zhai G^*. Oxygen-carrying nanoparticle-based chemo-sonodynamic therapy for tumor suppression and autoimmunity activation. 2021;9(11):3989-4004.

5. Zhang Y, Khan AR, Yang X, Shi Y,Zhao X^*, Zhai G^*. A sonosensitiser-based polymeric nanoplatform for chemo-sonodynamic combination therapy of lung cancer. Journal of nanobiotechnology. 2021;19(1):57.

6. Zhang C, Wu L, de Perrot M,Zhao X^*. Carbon Nanotubes: A Summary of Beneficial and Dangerous Aspects of an Increasingly Popular Group of Nanomaterials. Frontiers in oncology. 2021;11:693814.

7. Tian Y, Li P, Xiao Z, Zhou J, Xue X, Jiang N, Peng C, Wu L, Tian H, Popper H, Poh ME, Marcucci F, Zhang C^*,Zhao X^*. Triptolide inhibits epithelial-mesenchymal transition phenotype through the p70S6k/GSK3/β-catenin signaling pathway in taxol-resistant human lung adenocarcinoma. Translational lung cancer research. 2021;10(2):1007-19.

8. Li P, Zhang X, Murphy AJ, Costa M,Zhao X^*, Sun H. Downregulation of hedgehog-interacting protein (HHIP) contributes to hexavalent chromium-induced malignant transformation of human bronchial epithelial cells. Carcinogenesis. 2021;42(1):136-47.

9. Jiang N, Zhou J, Zhang W, Li P, Liu Y, Shi H, Zhang C, Wang Y, Zhou C, Peng C, Zhang W, Hao Y, Sun Q, Li Y^*,Zhao X^*. RNF213 gene mutation in circulating tumor DNA detected by targeted next-generation sequencing in the assisted discrimination of early-stage lung cancer from pulmonary nodules. 2021;12(2):181-93.

10. Zhao Y, Han L, Zhang W, Shan L, Wang Y, Song P, Peng C,Zhao X^*. Preoperative chemotherapy compared with postoperative adjuvant chemotherapy for squamous cell carcinoma of the thoracic oesophagus with the detection of circulating tumour cells randomized controlled trial. International journal of surgery (London, England). 2020;73:1-8.

11. Xiao Z, Tian Y, Jia Y, Shen Q, Jiang W, Chen G, Shang B, Shi M, Wang Z,Zhao X^*. RUNX3 inhibits the invasion and migration of esophageal squamous cell carcinoma by reversing the epithelial‑mesenchymal transition through TGF‑β/Smad signaling. Oncology reports. 2020;43(4):1289-99.

12. Zhao Y, Zhao S, Chen Y, Dong X, Peng C, Sun Q, Shan L, Wang Z,Zhao X^*. Isolation of circulating tumor cells in patients undergoing surgery for esophageal cancer and a specific confirmation method. Oncology letters. 2019;17(4):3817-25.

13. Zhang W, Luo J, Dong X, Zhao S, Hao Y, Peng C, Shi H, Zhou Y, Shan L, Sun Q, Li Y,Zhao X^*. Salivary Microbial Dysbiosis is Associated with Systemic Inflammatory Markers and Predicted Oral Metabolites in Non-Small Cell Lung Cancer Patients. Journal of Cancer. 2019;10(7):1651-62.

14. Shi H, Zhang L, Zhang C, Hao Y,Zhao X^*. Rapamycin may inhibit murine S180 sarcoma growth by regulating the pathways associated with autophagy and cancer stem cells. Journal of cancer research and therapeutics. 2019;15(2):398-403.

15. Liu Y, Zou ZQ, Xiao J, Zhang M, Yuan L,Zhao X^*. A nomogram prediction model for recurrent laryngeal nerve lymph node metastasis in thoracic oesophageal squamous cell carcinoma. Journal of thoracic disease. 2019;11(7):2868-77.

16. Zhang C, Hao Y, Wu L, Dong X, Jiang N, Cong B, Liu J, Zhang W, Tang D, De Perrot M^*,Zhao X^*. Curcumin induces apoptosis and inhibits angiogenesis in murine malignant mesothelioma. International journal of oncology. 2018;53(6):2531-41.

17. Jiang N, Dong XP, Zhang SL, You QY, Jiang XT,Zhao XG^*. Triptolide reverses the Taxol resistance of lung adenocarcinoma by inhibiting the NF-κB signaling pathway and the expression of NF-κB-regulated drug-resistant genes. Molecular medicine reports. 2016;13(1):153-9.