学习与工作经历：

1979.09-1985.07   山东医科大学 本科/学士

1985.09-1988.12    山东医科大学 硕士研究生/硕士

1993.09-1996.05    瑞典哥德堡大学 博士研究生/博士

1989.01-1990.04   山东大学齐鲁医院   住院医师

1990.04-1996.09   山东大学齐鲁医院   主治医师

1996.09-1999.01   山东大学齐鲁医院   副主任医师

1999.01 -至今     山东大学齐鲁医院   主任医师

1999.01 -至今     山东大学齐鲁医院   研究员

2000.05 -2022.10  山东大学齐鲁医院   血液科主任

2001.01 -至今     山东大学           教授、博士生导师

研究方向：

血小板相关疾病的诊断与干预; 血小板免疫学;原发免疫性血小板减少症(ITP) 

学术/社会兼职：

ITP国际工作组指南制定专家组         成员

美国血液学会                         资深会员

亚太血栓与止血学会                   执行委员

中华医学会血液学分会                 常务委员

中国病理生理学会实验血液学分会       常务委员

中国医师协会血液科医师分会           副会长

中国生理学会血栓与止血专业委员会     副主任委员

中国老年医学会血液学分会             副会长

山东省医学会血液病学分会             候任主任委员

山东省医学会临床分析细胞学专业委员会 主任委员

山东省抗癌协会                       副理事长

山东省抗癌协会血液肿瘤分会           主任委员

《中华血液学杂志》                   编委

Journal of Translational Internal Medicine   副主编

获奖荣誉：

教育部自然科学奖一等奖2项（第1位）

教育部自然科学奖二等奖1项（第1位）

教育部科技进步奖二等奖1项（第1位）

山东省自然科学奖二等奖4项（第1位）

山东省科技进步奖二等奖1项（第1位）

中华医学科技奖三等奖1项（第1位）

教育部科技进步奖一等奖1项

中华医学科技奖二等奖1项

华夏医学科技奖一等奖1项

华夏医学科技奖三等奖1项

泰山学者特聘专家

卫生部有突出贡献中青年专家

享受国务院政府特殊津贴

山东省医学领军人才

山东省有突出贡献的中青年专家

山东省十佳医师

山东省优秀研究生指导教师

山东大学优秀研究生指导教师

山东大学杰出医学专家

本科生课程：

《内科学》

研究生课程：

《血液系统疾病的诊断与治疗进展》、《血液免疫学：从基础到临床/Immunohematology: from bench to bedside》

1. 81973994 通过调控树突状细胞IDO 组蛋白乙酰化水平恢复 ITP 免疫耐受的机制研究 国家自然科学基金委 2020.01-2023.12 55万 主持

2. 81770114 TNFα 调控单核/巨噬系统亚群平衡从而恢复ITP 免疫耐受的机制研究 国家自然科学基金委 2018.01-2021.12 55万 主持

3. 81470284 去唾液酸化在原发免疫性血小板减少症发病中的作用和机制研究 国家自然科学基金委 2015.01-2018.12 80万 主持

4. ZR2016QZ008 ITP 中血小板自身抗体介导的非 Fc受体依赖的发病机制研究——领军人才前瞻性研究专题 山东省自然科学基金委 2016.11-2019.11 100万 主持

5. 侯明科技领军人才创新工作室 山东省科学技术厅 2018.04-2021.04 300万 主持

6. 2021LCZX05 免疫性血小板减少症中血小板生成的调控机制及联合治疗临床研究 山东省科学技术厅 2021.12-2024.12 300万 主持

1. Panpan Han, Yu Hou, Yajing Zhao, Yang Liu, Tianshu Yu, Yunqi Sun, Haoyi Wang, Pengcheng Xu, Guosheng Li, Tao Sun, Xiang Hu, Xinguang Liu, Lizhen Li, Jun Peng, Hai Zhou, Ming Hou（共同通讯）. Low-dose decitabine modulates T-cell homeostasis and restores immune tolerance in immune thrombocytopenia. Blood. 2021. 138(8):674-688

2. Hong-Yu Zhao, Ya-Hui Ma, Da-Qi Li, Tao Sun, Li-Zhen Li, Ping Li, Xin-Guang Liu, Hai Zhou, Yu Hou, Yang Liu, Pan-Pan Han, Ya-Jing Zhao, Fang-Miao Jing, Jun Peng, Ming Hou（共同通讯）. Low-dose chidamide restores immune tolerance in ITP in mice and humans. Blood. 2019. 133(7):730-742

3. Zhangyuan Kong, Ping Qin, Shan Xiao, Hai Zhou, Hong Li, Renchi Yang, Xiaofan Liu, Jianmin Luo, Zhichun Li, Guochao Ji, Zhongguang Cui, Yusheng Bai, Yuxia Wu, Linlin Shao, Jun Peng, Jun Ma, Ming Hou（共同通讯）. A novel recombinant human thrombopoietin therapy for the management of immune thrombocytopenia in pregnancy. Blood. 2017. 130(9):1097-1103

4. Yafei Yu, Miaomiao Wang, Yu Hou, Ping Qin, Qingshu Zeng, Wenzheng Yu, Xinhong Guo, Jingxia Wang, Xiaomin Wang, Guoqiang Liu, Xiaoxia Chu, Lan Yang, Ying Feng, Fang Zhou, Zhaogang Sun, Mei Zhang, Xin Wang, Zhencheng Wang, Xuehong Ran, Hongguo Zhao, Lei Wang, Haiyan Zhang, Kehong Bi, Daqi Li, Chenglu Yuan, Ruirong Xu, Yili Wang, Yuhong Zhou, Jun Peng, Xin-Guang Liu, Ming Hou （共同通讯）. High-dose dexamethasone plus recombinant human thrombopoietin vs high-dose dexamethasone alone as frontline treatment for newly diagnosed adult primary immune thrombocytopenia: A prospective, multicenter, randomized trial. American Journal of Hematology. 2020. 95(12):1542-1552

5. Hai Zhou, Ping Qin, Qiang Liu, Chenglu Yuan, Yunliang Hao, Haiyan Zhang, Zhencheng Wang, Xuehong Ran, Xiaoxia Chu, Wenzheng Yu, Xin Wang, Yu Hou, Jun Peng, Ming Hou（独立通讯）. A prospective, multicenter study of low dose decitabine in adult patients with refractory immune thrombocytopenia. American Journal of Hematology. 2019. 94(12):1374-1381

6. Qian Wang, Juan Li, Tian-Shu Yu, Yu Liu, Kai Li, Shuang Liu, Yang Liu, Qi Feng, Lei Zhang, Guo-Sheng Li, Lin-Lin Shao, Jun Peng, Ming Hou, Xin-Guang Liu（共同通讯）. Disrupted balance of CD4 + T-cell subsets in bone marrow of patients with primary immune thrombocytopenia. International Journal of Biological Sciences. 2019. 15(13):2798-2814

7. Shuang Wang, Yang Liu, Guosheng Li, Qi Feng, Ming Hou, Jun Peng（共同通讯）. Reduced intracellular antioxidant capacity in platelets contributes to primary immune thrombocytopenia via ROS-NLRP3-caspase-1 pathway. Thrombosis Research. 2021. 199:1-9

8. Ju Li, Mingqiang Hua, Xiang Hu, Yanqi Zhang, Qi Feng, Jihua Qiu, Linlin Shao, Nailin Li, Ming Hou, Jun Peng（共同通讯）. Dexamethasone suppresses the Th17/1 cell polarization in the CD4 + T cells from patients with primary immune thrombocytopenia. Thrombosis Research. 2020. 190:26-34

9. Fang-Miao Jing, Xiao-Lin Zhang, Fan-Li Meng, Xiao-Ming Liu, Yan Shi, Ping Qin, Lin Wang, Hai Zhou, Yu Hou, Qiang Song, Jun Peng, Ming Hou（共同通讯）. Anti-c-Mpl antibodies in immune thrombocytopenia suppress thrombopoiesis and decrease response to rhTPO. Thrombosis Research. 2018. 170:200-206

10. Panpan Han, Tianshu Yu, Yu Hou, Yajing Zhao, Yang Liu, Yunqi Sun, Haoyi Wang, Pengcheng Xu, Guosheng Li, Tao Sun, Xiang Hu, Xinguang Liu, Lizhen Li, Jun Peng, Hai Zhou, Ming Hou（共同通讯）. Low-Dose Decitabine Inhibits Cytotoxic T Lymphocytes-Mediated Platelet Destruction via Modulating PD-1 Methylation in Immune Thrombocytopenia. Frontiers in Immunology. 2021. 12:630693

11. Xinru Wang, Lizhen Li, Yuanjian Wang, Xin Li, Qi Feng, Yu Hou, Chunhong Ma, Chengjiang Gao, Ming Hou, Jun Peng（共同通讯）. High-Dose Dexamethasone Alters the Increase in Interleukin-16 Level in Adult Immune Thrombocytopenia. Frontiers in Immunology. 2019. 10:451

12. Ju Li, Sai Ma, Linlin Shao, Chunhong Ma, Chengjiang Gao, Xiao-Hui Zhang, Ming Hou, Jun Peng（共同通讯）. Inflammation-Related Gene Polymorphisms Associated With Primary Immune Thrombocytopenia. Frontiers in Immunology. 2017. 8:744

13. Yafei Yu, Yu Hou, Yajing Zhao, Hai Zhou, Fangmiao Jing, Yanfeng Liu, Jun Peng, Xinguang Liu, Ming Hou（共同通讯）. Platelet autoantibody specificity and response to rhTPO treatment in patients with primary immune thrombocytopenia. British Journal of Haematology. 2021. 194(1):191-194

14. Yajing Zhao, Pengcheng Xu, Li Guo, Haoyi Wang, Yanan Min, Qi Feng, Yu Hou, Tao Sun, Guosheng Li, Xuebin Ji, Jihua Qiu, Jun Peng, Xinguang Liu, Ming Hou（共同通讯）. Tumor Necrosis Factor-α Blockade Corrects Monocyte/Macrophage Imbalance in Primary Immune Thrombocytopenia. Thrombosis and Haemostasis. 2021. 121(6):767-781

15. Xin Li, Shu-Wen Wang, Qi Feng, Yu Hou, Nan Lu, Chun-Hong Ma, Cheng-Jiang Gao, Ming Hou, Jun Peng（共同通讯）. Novel Murine Model of Immune Thrombocytopaenia through Immunized CD41 Knockout Mice. Thrombosis and Haemostasis. 2019. 119(3):377-383

16. Yang Liu, Rui Wang, Panpan Han, Yajing Zhao, Guijie Li, Guosheng Li, Mu Nie, Lingjun Wang, Jian Chen, Xuena Liu, Ming Hou （共同通讯）. Effect of recombinant human thrombopoietin on immune thrombocytopenia in pregnancy in a murine model. International Immunopharmacology. 2019. 67:287-293

17. Yang Liu, Shidong Qiu, Lingjun Wang, Na Zhang, Yan Shi, Hai Zhou, Xinguang Liu, Linlin Shao, Xuena Liu, Jian Chen, Ming Hou（独立通讯）. Reproductive and developmental toxicity study of caffeic acid in mice. Food And Chemical Toxicology. 2019. 123:106-112

18. Yajing Zhao, Panpan Han, Lei Liu, Xiaojie Wang, Pengcheng Xu, Haoyi Wang, Tianshu Yu, Yunqi Sun, Lizhen Li, Tao Sun, Xinguang Liu, Hai Zhou, Jihua Qiu, Liang Wang, Jun Peng, Shuqian Xu, Ming Hou（共同通讯）. Indirubin modulates CD4 + T-cell homeostasis via PD1/PTEN/AKT signalling pathway in immune thrombocytopenia. Journal Of Cellular And Molecular Medicine. 2019. 23(3):1885-1898

19. Liang Wang, Lei Xu, Hongyuan Hao, A J Gerard Jansen, Guoqiang Liu, Honglei Li, Xinguang Liu, Yajing Zhao, Jun Peng, Ming Hou （独立通讯）. First line treatment of adult patients with primary immune thrombocytopenia: a real-world study. Platelets. 2020. 31(1):55-61

20. Ming-Ming Qu, Xue-Na Liu, Xin-Guang Liu, Qi Feng, Yang Liu, Xu Zhang, Shuang Liu, Lei Zhang, Guo-Sheng Li, Yuan-Yuan Zhu, Ming-Yun Lv, Jun Peng, Ming Hou （共同通讯）. Cytokine changes in response to TPO receptor agonist treatment in primary immune thrombocytopenia. Cytokine. 2017. 92:110-117

21. Chun-Yan Wang, Sai Ma, Shao-Jie Bi, Le Su, Shu-Ya Huang, Jun-Ying Miao, Chun-Hong Ma, Cheng-Jiang Gao, Ming Hou, Jun Peng（共同通讯）. Enhancing autophagy protects platelets in immune thrombocytopenia patients. Annals of Translational Medicine. 2019. 7(7):134

22. Xin-Guang Liu, Xiao-Chuan Bai, Fang-Ping Chen, Yun-Feng Cheng, Ke-Sheng Dai, Mei-Yun Fang, Jian-Ming Feng, Yu-Ping Gong, Tao Guo, Xin-Hong Guo, Yue Han, Luo-Jia Hong, Yu Hu, Bao-Lai Hua, Rui-Bing Huang, Yan Li, Jun Peng, Mi-Mi Shu, Jing Sun, Pei-Yan Sun, Yu-Qian Sun, Chun-Sen Wang, Shu-Jie Wang, Xiao-Min Wang, Cong-Ming Wu, Wen-Man Wu, Zhen-Yu Yan, Feng-E Yang, Lin-Hua Yang, Ren-Chi Yang, Tong-Hua Yang, Xu Ye, Guang-Sen Zhang, Lei Zhang, Chang-Cheng Zheng, Hu Zhou, Min Zhou, Rong-Fu Zhou, Ze-Ping Zhou, Hong-Li Zhu, Tie-Nan Zhu, Ming Hou（独立通讯）. Chinese guidelines for treatment of adult primary immune thrombocytopenia. International Journal of Hematology. 2018. 107(6):615-623