学习与工作经历：

2002.09-2007.06 滨州医学院 临床医学 本科

2007.09-2010.06 山东大学 硕士研究生

2010.09-2014.06 山东大学 博士研究生

2011.09-2013.09 University of Florida(Joint PhD)

2014.07-2015.05 山东大学齐鲁医院 泌尿外科 住院医师

2015.06-2021.08 山东大学齐鲁医院 泌尿外科 主治医师

2021.09-至今 山东大学齐鲁医院 泌尿外科 副主任医师

2022.05-至今 山东大学齐鲁医院 副教授、硕士研究生导师

研究方向：

1.前列腺癌的纳米材料、免疫、靶向、放射增敏治疗的基础与临床研究；

2.泌尿系结石及脓毒血症的基础与临床研究。 

学术/社会兼职：

山东省医学会泌尿外科分会结石学组委员，山东省医师协会泌尿外科分会结石学组委员，山东省研究型医院协会泌尿外科学分会委员，山东省健康管理协会泌尿结石专业委员会委员，山东省激光医学会生殖医学专业委员会委员，山东省抗癌协会泌尿男生殖系肿瘤分会青年委员会委员，山东省山东省医学伦理学学会转化医学分会常委，山东省研究型医院协会精准肿瘤分会介入微创治疗委员会委员

获奖荣誉：

本科生课程：

《智医-泌尿系统疾病诊疗技术》

《慕课-微创医学-内镜在泌尿系结石手术中的应用及创新》

研究生课程：

82172743  PSMA靶向介导rAVV2-E1A12联合PI3K/AKT/mTOR通路抑制剂治疗前列腺癌的研究  国家自然科学基金(面上项目)  2022.01-2025.12  55万元  项目负责人 

ZR2021MH029 PSMA靶向介导前列腺癌rAAV2-E1A12基因治疗体系的研发  山东省自然科学基金(面上项目)  2022.01-2024.12  10万元  项目负责人 

81502213  腺病毒12型E1A抑制前列腺癌细胞雄激素受体功能的分子机制研究  国家自然科学基金(青年项目)  2016.01-2018.12  21.6万元  项目负责人

1.Liu Z^#, Li D^#, Yan L, Xu Z, Gu G*. Comparison of lateral transperitoneal and retroperitonial approaches for homolateral laparoscopic adrenalectomy. BMC Surgery 2021, 21(1):432.(共同第一).

2.Chen D^#，Li D^#，Cui Z，Zhang C，Zhang Z，Yan L*. Evaluation of the value of Preoperative Sialic Acid Levels in Diagnosis and Localization of Urothelial Tumors. Journal of Cancer 2021, 12(16): 5066-5075.(共同第一).

3.Bing Ji^#, Dawei Li^#, Shuai Fu^#, Zhao Zhang, Tong Yang, Yaohai Wu, You Zuo, Zhonghua Xu , Nengwang Yu*.Propensity-score matched comparison ofpartial versus radical nephrectomy for T1N0M0 sarcomatoid renal cell carcinoma. Transl Androl and Urol 2020,9(2):250-257.(共同第一).

4.Li D^#, Tian G^#, Wang J, Zhao LY, Co O, Underill ZC, Mymryk JS, Claessens F, Dehm SM, Daaka Y, Liao D*.Inhibition of androgen receptor transactivation function by adenovirus type 12 E1A undermines prostate cancer cell survival.Prostate 2018,78(15):1140-1156.(共同第一).

5.Wang Y^#,Li D^#, Luo J, Tian G, Zhao LY, Liao D*. Intrinsic cellular signaling mechanisms determine the sensitivity of cancer cells to virus-induced apoptosis. Sci Rep 2016, 16:37213. (共同第一).

6.Liu J^#,Li D^#, Cao L, Wang Z, Li Y, Liu H, Chen G*. Elevated preoperative plasma fibrinogen level is an independent predictor of malignancy and advanced stage disease in patients with bladder urothelial tumors. Int J Surg 2016, 36(Pt A):249-254. (共同第一).

7.Li D^#, Han Z, Liu J, Zhang X, Ren J, Yan L, Liu H, Xu Z*. Upregulation of nucleus HDGF predicts poor prognostic outcome in patients with penile squamous cell carcinoma bypass VEGF-A and Ki-67. Med Oncol 2013, 30(4):702.(第一作者).

8.Li D^#, Liu J, Zhang W, Ren J, Yan L, Liu H*, Xu Z*. Association between HIF1A P582S and A588T Polymorphisms and the Risk of Urinary Cancers: A Meta-Analysis. PLoS One 2013, 8(5):e63445.(第一作者).

9.Li D^#, Liu J^#, Ren J, Yan L, Liu H*, Xu Z*. Meta-analysis of the urokinase gene 3'-UTR T/C polymorphism and susceptibility to urolithiasis. Biomedical Reports 2013, 1(3):369-374.(共同第一).

10.Li D^#, Liu H^#, Yan L, Tang Y, Ren J, Xu Z*.Lack of association between hOGG1 Ser326Cys polymorphism and the risk of bladder cancer: a meta-analysis. Urol Int 2012(1), 88:88-94.(共同第一).

11.Li D^#, Tian T, Guo C, Ren J, Yan L*, Liu H, Xu Z*.No association of the MTHFR gene A1298C polymorphism with the risk of prostate cancer: A meta-analysis. Exp Ther Med 2012, 3(3):493-498.(第一作者).

12.Zhang C^#, Chang X, Chen D, Yang F, Li Z ,Li D*, Yu N, Yan L, Liu H, Xu Z. Downregulation of HDGF inhibits the tumorigenesis of bladder cancer cells by inactivating the PI3K-AKT signaling pathway. Cancer Management and Research 2019, 11: 7909-7923.(通讯作者).

13.Zhang C^#, Yan L^#, Song H, Ma Z, Chen D, Yang F, Fang L, Li Z, Li K,Li D*, Yu N, Liu H, Xu Z. Elevated Serum Sialic Acid levels Predict Prostate Cancer As Well As Bone Metastases. Journal of Cancer 2019, 10(2): 449-457.(通讯作者).

14.Zhang C^#, Yu N, Yang F, Wang H, Zhang Z,Li D*,Yan L, Liu H, Xu Z. Cystoscopic Biopsy Should Be a Remedy for The Failing of Postoperative Pathology in Patients with Bladder Urothelial Tumors: A Single Center Study Based on Eight Years’ Experience. Journal of Urology and Renal Disease 2018,5: DOI: 10.29011/2575-7903.000096.(通讯作者).

15.Wang H^#, Gao L^#, Meng C, Yu N, Yang F, Zhang C,Li D*,Yan L, Liu H, Xu Z.Serum Cystatin C levels Is Not a Promising Biomarker for Predicting Clinicopathological Characteristics.Biomed Res Int 2018, 2617439: DOI: 10.1155/2018/2617439.(通讯作者).

16.Yang F^#, Yu N^#, Wang H, Zhang C, Zhang Z, Li Y,Li D*,Yan L, Liu H, Xu Z.Downregulated expression of hepatoma-derived growth factor inhibits migration and invasion of prostate cancer cells by suppressing epithelial-mesenchymal transition and MMP2, MMP9.Plos One 2018, 13(1): e0190725.(通讯作者).

17.Yang F^#,Li D^#*,Di Y, Zhang Y, Zang Y, Ren J, Yan L, Zhou Z, Liu H, Xu Z.Pretreatment Serum Cystatin C Levels Predict Renal Function, but Not Tumor Characteristics, in Patients with Prostate Neoplasia.Biomed Res Int 2017, 7450459: DOI: 10.1155/2018/2617439.(通讯作者).