学习与工作经历：

2006年获山东大学风湿病专业博士学位，博士研究生学历；

1997年至今 在山东大学齐鲁医院风湿科工作， 现为主任医师，科室主任

2007-2008年为美国宾夕法尼亚大学客座教授，从事系统性红斑狼疮研究；2010-2011年在美国密歇根大学博士后工作经历，从事类风湿关节炎研究。

研究方向：

1.早期和难治性类风湿关节炎（RA）的基础与临床；

2.风湿病（CTD）相关肺间质病变（ILD）的临床诊治与应答机制研究；

3.抗磷脂综合征（APS）、风湿病相关不良妊娠慢病患者管理。

学术/社会兼职：

中国医师协会风湿免疫科医师分会 风湿病相关肺血管/间质病学组委员

山东省医师协会风湿免疫学医师分会主任委员

山东省康复医学会风湿病学分会 主任委员

山东省医学会风湿病学分会 副主任委员兼秘书

获奖荣誉：

获得山东科学技术进步奖三等奖，山东医学科技奖二等奖各一项，

2017年被授予齐鲁医学院“齐鲁医学优秀教师”称号，2020年度齐鲁医院疑难危重症病例评比一等奖， 2022年山东省医学会急危重病例奖二等奖。

本科生课程：

1.《内科学》风湿病专业部分

2《感染免疫与相关疾病》的风湿病专业部分

研究生课程：

1.主持开设《风湿免疫病学新进展及临床实践》课程；

2.讲授《骨质疏松》课程

1.SDUZHJ（2023）0716 利妥昔单抗续贯泰它西普治疗系统性红斑狼疮继发抗磷脂综合症的有效性和安全性临床研究 山东省科技厅  2023.02-2023.10 50万 主持

2.ZH2022MH177 Galectin-9 在 RA 中对 TNF-α 介导 FLS 焦亡的调控作用研究 山东省科技厅  2023.01-2025.12， 10万 主持

3.乏氧培养的人脐带间充质干细胞（MSC）治疗RA合并肺间质病变动物模型的疗效和安全性及作用机制的研究，横向，2022.12-2024.05，120万，主持

4.吡非尼酮治疗结缔组织病相关肺间质病变（CTD-ILD）的疗效与免疫功能变化的研究—单中心随机对照前瞻性队列研究。横向课题 2023.02至2025.10，110万,主持

1.Chunfeng Ren^#,Jie Chen^#,Qincheng Che,Qian Jia,Hongqin Lu,Xiaoyan Qi,Xiaojie Zhang,Qiang Shu*.IL-37 alleviates TNF-α-induced pyroptosis of rheumatoid arthritis fibroblast-like synoviocytes by inhibiting the NF-κB/GSDMD signaling pathway.Immunobiology.2023;228(3):152382.PMID: 37075579

2.Che QC#, Jia Q#, Zhang XY, Sun SN, Zhang XJ,Shu Q^#. Aprospectivestudyof theassociationbetweenserumklothoand mortality among adults with rheumatoid arthritis in the USA.Arthritis Res Ther. 2023 Aug 16; 25(1):149. PMID: 37587536

3.Jie Chen,#, Qincheng Che#, Yuying Kou#, Xing Rong, Xiaojie Zhang, Minqi Li,Qiang Shu*.A Novel Drug Combination of Tofacitinib and Iguratimod Alleviates Rheumatoid Arthritis and Secondary Osteoporosis.International Immunopharmacology. 2023,124（PtB):110913

4.Hui-hui Li#, Lin-tao Sai#, Shan Tian, Yuan Liu, Colman Free, Kai Wang, Jing Zheng,Qiang Shu*, Ying-jie Zhao*. Sexual Dimorphisms of Protein-codingGene Profiles in Placentas from Womenwith Systemic Lupus Erythematosus Department of Obstetrics and Gynecology,Frontiers in Medicine2022 Mar 15; 9:798907. doi: 10.3389/fmed.2022.798907. PMID: 35372436;

5.Qi Liu#, Yuxian Zhang#, Hongqin Lu, Peng Yan, Xue Bai, Lili Cao, Xiuli Zuo, Chao Liu,Qiang Shu*. Cholineraic dysautonomia in a patient with systemic lupus ervthematosus.Rheumatology (Oxford).2022 Jul 5; doi:10.1093/rheumatology /keac373;

6.Jiaqi Wang#, Xiao Wang, Xiaoyan Qi, Zhijian Sun, Tao Zhang, Yi Cui,Qiang Shu*.The Efficacy and Safety of Pirfenidone Combined With Immunosuppressant Therapy in Connective Tissue Disease-Associated Interstitial Lung Disease: A 24-Week Prospective Controlled Cohort Study.Frontiers in Medicine. 2022 May 12:9:871861. doi: 10.3389/fmed2022.87161.PMID: 35646960.

7.Hui-hui Li#, Lin-tao Sai#, Yuan Liu, Colman Free, Kai Wang, Chi Zhou, Jing Zheng,Qiang Shu*, Ying-jie Zhao*.Systemic lupus erythematosus dysregulates the expression of long noncoding RNAs in placentas.Arthritis Res Ther.2022 Jun 14; 24(1):142.doi: 10.1186/s13075-022-02825-7.PMID:35701843

8.Sun Z#, Wang F#, Chen J, Liu X, Sun J, Sui Y, Zhang X,Shu Q*.Establishment and verification of a nomogram and a preliminary study on predicting the clinical response of conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) in rheumatoid arthritis patients.Ann Transl Med2022. doi: 10.21037/atm-22-5791PMID:36660697

9.Sun J, Sui Y, Wang Y, Song L, Li D, Li G, Liu JW,Shu Q^*. Galectin-9 expression correlates with therapeutic effect in rheumatoid arthritis.Sci Rep.2021; 11(1):5562. Epub 2021/03/12. doi: 10.1038/s41598-021-85152-2. PMID: 33692448;

10.Wang Y, Song L, Sun J, Sui Y, Li D, Li G, Liu JW,Shu Q^*. Expression of Galectin-9 and correlation with disease activity and vascular endothelial growth factor in rheumatoid arthritis.Clin Exp Rheumatol.2020;38(4):654-61. PMID: 31820713.

11.Li J, Bao J, Zeng J, Yan A, Zhao C,Shu Q^*. Iguratimod: a valuable remedy from the Asia Pacific region for ameliorating autoimmune diseases and protecting bone physiology. Bone Res. 2019; 7:27. PMID: 31646017

12.Song L^#, Wang Y^#, Sui Y, Sun J, Li D, Li G,Liu JW, Li TW*,Shu Q^*. High Interleukin-37 (IL-37) Expression and Increased Mucin-Domain Containing-3 (TIM-3) on Peripheral T Cells in Patients with Rheumatoid Arthritis. Med Sci Monit.2018;24:5660-7. PMID: 30106887

13.O'Brien MJ^#,Shu Q^#, Stinson WA, Tsou PS, Ruth JH, Isozaki T, et al. A unique role for galectin-9 in angiogenesis and inflammatory arthritis.Arthritis Res Ther. 2018; 20(1):31. PMID: 29433546

14.Song LJ^#, Wang X^#, Wang XP, Li D, Ding F, Liu HX,Shu Q^*et al. Increased Tim-3 expression on peripheral T lymphocyte subsets and association with higher disease activity in systemic lupus erythematosus.Diagn Pathol. 2015;10:71. PMID: 26076826

15.Shu Q^#, Amin MA, Ruth JH, Campbell PL, Koch AE^*. Suppression of endothelial cell activity by inhibition of TNFalpha.Arthritis Res Ther.2012;14(2):R88. doi: 10.1186/ar3812. PMID: 22534470

16.Liu Y^#,Shu Q^#, Gao L, Hou N, Zhao D, Liu X, et al. Increased Tim-3 expression on peripheral lymphocytes from patients with rheumatoid arthritis negatively correlates with disease activity.Clin Immunol. 2010;137(2):288-95.PMID: 20805041