学习与工作经历：

2007年师从中国工程院张运院士攻读博士学位，2010年进入山东大学齐鲁医院工作。目前担任山东大学齐鲁医院心内科主任医师，科副主任；山东大学教授，博士生导师。主要从事冠心病、高血压、心力衰竭等心血管疾病的诊治，尤其擅长心血管疾病介入治疗和危重症救治。

研究方向：

心血管重构分子机制、干预靶点和预警策略；临床心血管流行病学。

学术/社会兼职：

《Journal of Geriatric Cardiology》编委

美国心脏病学院Fellow（FACC）

中国医促会心脏重症医学分会常委

中华医学会心血管病学分会急重症学组委员

中国医师协会心内科分会动脉粥样硬化学组委员

山东省医药教育协会心脏重症专业委员会主任委员

山东省医学会心血管病学分会危重症学组组长

山东省医师协会心血管内科诊疗能力提升专委会副主任委员

国家标准化心血管与代谢中心山东省中心主任

山东省医学会地方病学会副主任委员

山东医药教育协会心脏重症专业委员会主任委员

山东省医药教育协会心脏介入专业委员会副主任委员

 

学术奖励:

 《动脉粥样硬化性心血管疾病早期预警和干预体系的建立和临床应用》，山东省科技进步二等奖，2025年，第一完成人

获奖荣誉：

首批山东省齐鲁卫生与健康杰出青年人才，首届山东大学齐鲁医学院名医（杰出青年医师），山东大学齐鲁医院杰出青年人才。

本科生课程：

内科学

研究生课程：

临床心脏病学

（1）山东省自然科学基金重大基础研究项目“基于多组学分析的动脉粥样硬化疾病发生发展的关键机制和干预策略研究”子课题负责人，经费：60万元。

（2）国家重点研发计划“心肌纤维化演变机理探索与无创精准影像评价体系构建”子课题，经费：60万。

（3）国家自然科学基金面上项目“Collectrin调控动脉粥样硬化的作用及机制研究”，负责人，经费：66万。

（4）国家自然科学基金面上项目“ACE2-Ang-(1-7)轴在心肌缺血再灌注损伤中的作用及其机制研究”，负责人，经费：68.4万。

（5）国家自然科学基金青年科学基金“JAML在动脉粥样硬化发生发展中作用机制的研究”，负责人，经费23万。

（6）山东省重点研发计划（科技示范工程）“重大心血管疾病智能化精准诊疗新技术开发与示范应用”，经费：3200万。第5位。

1.        Liu X, Chen L, Liu C, Mei Z, Li J, Zhang Y, Chang M, Zhang H, Guo C, Zhang M, An G, Yang J, Chen W, Xue Y, Zhang C, Ni M, Zhang Y. Percutaneous coronary intervention as an independent predictor of non-target lesion progression in 1658 patients with coronary artery disease. Theranostics. 2026;16:3857-3869.

2.        Leng L, Liu X, Song C, Ran X, Lin Z, Zhai C, Qin X, Cao G, Zhang C, Yang J. Intra-aortic balloon pump implantation in early-stage cardiogenic shock reduces 30-day mortality in patients with ventricular septal defect following myocardial infarction. Int J Cardiol. 2026;442:133895.

3.        Cui X, Wang Y, Lu H, Wang L, Xie X, Zhang S, Kovarik P, Li S, Liu S, Zhang Q, Yang J, Zhang C, Tian J, Liu Y, Zhang W. ZFP36 Regulates Vascular Smooth Muscle Contraction and Maintains Blood Pressure. Adv Sci (Weinh). 2025;12:e2408811.

4.        Sun X, Wu Z, Guo D, Chen S, Song C, Ran X, Liu L, Zhang Y, Liu X, Cao G, Yang J. Triglyceride-glucose index as a superior marker of insulin resistance for predicting long-term major adverse cardiovascular events following coronary artery bypass grafting in China. Sci Rep. 2025;15:6450.

5.        Lu H, Wu Z, Wan M, Xiong S, Huang X, Liu T, Jiang X, He L, Ma C, Cui H, Yue X, Li J, Qin X, Wang Y, Zhang C, Yang J, Liu S, Zhang W. Taurochenodeoxycholic acid alleviates obesity-induced endothelial dysfunction. Eur Heart J. 2025:ehaf766 [pii].

6.        Liu Y, Zheng Y, Zhao X, Dong Z, Zhang M, Fang Y, Wang Y, Wang Z, Liu N, Yan P, Ma Y, Yang F, Zheng Y, Zhang W, Yang J, Sun M. Targeting JAML promotes normalization of tumour blood vessels to antagonize tumour progression via FAK/SRC and VEGF/VEGFR2 signalling pathways. Life Sci. 2025;368:123474.

7.        Chen A, Yuan P, Lu Y, Ma C, Xue F, Yang J, Zhang Y, Zhang W. Smooth muscle-specific HuR knockout attenuates vascular calcification. J Mol Cell Cardiol. 2025;205:117-128.

8.        Cui H, Xie L, Lu H, Cheng C, Xue F, Wu Z, Liu L, Qiao L, Zhang C, Zhang W, Yang J. Macrophage junctional adhesion molecule-like (JAML) protein promotes NLRP3 inflammasome activation in the development of atherosclerosis. Cell Death Differ. 2025;32:1763-1776.

9.        He LF, Wang L, Li JW, Xiong X, Yue XL, Yuan PD, Lu HL, Gao JG, Yu FP, Chen M, Weinstein LS, Yang JM, Zhang C, Qin X, Zhang W. Endothelial Gsα deficiency promotes ferroptosis and exacerbates atherosclerosis in apolipoprotein E-deficient mice via the inhibition of NRF2 signaling. Acta Pharmacol Sin. 2025;46:1289-1302.

10.      Wang Y, Guo D, Wang Y, Yang J, Li P. Correlation analysis of ApoB and TyG index levels with residual cardiovascular risk in patients with acute myocardial infarction. Front Endocrinol (Lausanne). 2025;16:1542190.

11.      Tian Z, Yang L, Li Y, Huang Y, Yang J, Xue F. Associations of different insulin resistance-related indices with the incidence and progression trajectory of cardiometabolic multimorbidity: a prospective cohort study from UK biobank. Cardiovasc Diabetol. 2025;24:257.

12.      Ran X, Wu Z, Guo D, Zhang S, Liu L, Chen S, Song C, Zhang C, Yang J. Association between the atherogenic index of plasma and major adverse cardiovascular events in patients with premature coronary artery disease. Eur J Med Res. 2025;30:511.

13.      Liu L, Peng J, Zang D, Zhang Y, Wu Z, Song C, Chen S, Guo D, Lu F, Zheng T, Yang J. The Chinese visceral adiposity index: a novel indicator more closely related to cardiovascular disease than other abdominal obesity indices among postmenopausal women. J Transl Med. 2024;22:855.

14.      Zhang Y, Peng J, Liu L, Cui H, Zang D, Wu Z, Guo D, Liu X, Lu F, Yang J. Prevalence, characteristics and significant predictors for cardiovascular disease of patients with preserved ratio impaired spirometry: A 10-year prospective cohort study in China. Respir Med. 2024;222:107523.

15.      Lu Y, Meng L, Ren R, Wang X, Sui W, Xue F, Xie L, Chen A, Zhao Y, Yang J, Zhang W, Yu X, Xi B, Xu F, Zhang M, Zhang Y, Zhang C. Paraspeckle protein NONO attenuates vascular calcification by inhibiting bone morphogenetic protein 2 transcription. Kidney Int. 2024;105:1221-1238.

16.      Guo D, Zhang C, Zhang M, Wu Z, Liu X, Zhang Y, Liu L, Sun M, Yang J. Metabolic score for insulin resistance predicts major adverse cardiovascular event in premature coronary artery disease. Aging (Albany NY). 2024;16:6364-6383.

17.      Ma C, Li Y, Tian M, Deng Q, Qin X, Lu H, Gao J, Chen M, Weinstein LS, Zhang M, Bu P, Yang J, Zhang Y, Zhang C, Zhang W. Gsα Regulates Macrophage Foam Cell Formation During Atherosclerosis. Circ Res. 2024;134:e34-e51.

18.      Liu L, Peng J, Wang N, Wu Z, Zhang Y, Cui H, Zang D, Lu F, Ma X, Yang J. Comparison of seven surrogate insulin resistance indexes for prediction of incident coronary heart disease risk: a 10-year prospective cohort study. Front Endocrinol (Lausanne). 2024;15:1290226.

19.      Xie L, Zang D, Yang J, Xue F, Sui W, Zhang Y. Combination of ADAM17 knockdown with eplerenone is more effective than single therapy in ameliorating diabetic cardiomyopathy. Front Pharmacol. 2024;15:1364827.

20.      Xie L, Xue F, Cheng C, Sui W, Zhang J, Meng L, Lu Y, Xiong W, Bu P, Xu F, Yu X, Xi B, Zhong L, Yang J, Zhang C, Zhang Y. Cardiomyocyte-specific knockout of ADAM17 alleviates doxorubicin-induced cardiomyopathy via inhibiting TNFα-TRAF3-TAK1-MAPK axis. Signal Transduct Target Ther. 2024;9:273.

21.      Guo D, Wu Z, Xue F, Chen S, Ran X, Zhang C, Yang J. Association between the triglyceride-glucose index and impaired cardiovascular fitness in non-diabetic young population. Cardiovasc Diabetol. 2024;23:39.

22.      Wu Z, Xie L, Guo D, Chen S, Liu X, Sun X, Wang J, Zhang Y, Liu L, Cui H, Zang D, Yang J. Triglyceride-glucose index in the prediction of adverse cardiovascular events in patients without diabetes mellitus after coronary artery bypass grafting: a multicenter retrospective cohort study. Cardiovasc Diabetol. 2023;22:230.

23.      Wu Z, Cheng C, Sun X, Wang J, Guo D, Chen S, Zhang Y, Liu X, Liu L, Zhang C, Yang J. The synergistic effect of the triglyceride-glucose index and serum uric acid on the prediction of major adverse cardiovascular events after coronary artery bypass grafting: a multicenter retrospective cohort study. Cardiovasc Diabetol. 2023;22:103.

24.      Zhang S, Wu Z, Zhuang Y, Sun X, Wang J, Chen S, Guo D, Xu P, Zhang C, Yang J. The metabolic score for insulin resistance in the prediction of major adverse cardiovascular events in patients after coronary artery bypass surgery: a multicenter retrospective cohort study. Diabetol Metab Syndr. 2023;15:157.

25.      Wu Z, Cui H, Zhang Y, Liu L, Zhang W, Xiong W, Lu F, Peng J, Yang J. The impact of the metabolic score for insulin resistance on cardiovascular disease: a 10-year follow-up cohort study. J Endocrinol Invest. 2023;46:523-533.

26.      Deng Q, Li H, Yue X, Guo C, Sun Y, Ma C, Gao J, Wu Y, Du B, Yang J, Zhang C, Zhang W. Smooth muscle liver kinase B1 inhibits foam cell formation and atherosclerosis via direct phosphorylation and activation of SIRT6. Cell Death Dis. 2023;14:542.

27.      Zhang Y, Cheng C, Wei F, Wu Z, Cui H, Liu L, Lu F, Peng J, Yang J. Reduced peak expiratory flow predicts increased risk of cardiovascular disease: A 10-year prospective cohort study in Eastern China. Respir Med Res. 2023;83:100988.

28.      Wu Z, Li H, Zhang Q, Yang J. Rare exacerbation of myocardial bridge after septal myocardial ablation in hypertrophic obstructive cardiomyopathy: a case report. Eur Heart J Case Rep. 2023;7:ytad168.

29.      Wu Z, Liu Z, Zhang Q, Zhang H, Cui H, Zhang Y, Liu L, Wang H, Yang J. Plasma junctional adhesion molecule C levels are associated with the presence and severity of coronary artery disease. Clin Biochem. 2023;118:110605.

30.      Cheng C, Zhang J, Li X, Xue F, Cao L, Meng L, Sui W, Zhang M, Zhao Y, Xi B, Yu X, Xu F, Yang J, Zhang Y, Zhang C. NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice. Signal Transduct Target Ther. 2023;8:290.

31.      Lu H, Jiang X, He L, Ji X, Li X, Liu S, Sun Y, Qin X, Xiong X, Philipsen S, Xi B, Zhang M, Yang J, Zhang C, Zhang Y, Zhang W. Endothelial Sp1/Sp3 are essential to the effect of captopril on blood pressure in male mice. Nat Commun. 2023;14:5891.

32.      Wu Z, Guo D, Chen S, Sun X, Zhang Y, Liu X, Liu L, Lin Z, Yang J. Combination of the triglyceride-glucose index and EuroSCORE II improves the prediction of long-term adverse outcomes in patients undergoing coronary artery bypass grafting. Diabetes Metab Res Rev. 2023;39:e3710.

33.      Cai G, Li C, Li J, Yang J, Li C, Sun L, Li J, Yu J, Meng X. Cardiac Substructures Dosimetric Predictors for Cardiac Toxicity After Definitive Radiotherapy in Esophageal Cancer. Int J Radiat Oncol Biol Phys. 2023;115:366-381.

34.      Lu H, Yuan P, Ma X, Jiang X, Liu S, Ma C, Philipsen S, Zhang Q, Yang J, Xu F, Zhang C, Zhang Y, Zhang W. Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice. Nat Commun. 2023;14:731.

35.      Wu Z, Liu L, Wang W, Cui H, Zhang Y, Xu J, Zhang W, Zheng T, Yang J. Triglyceride-glucose index in the prediction of adverse cardiovascular events in patients with premature coronary artery disease: a retrospective cohort study. Cardiovasc Diabetol. 2022;21:142.

36.      He L, Lu H, Ji X, Chu J, Qin X, Chen M, Weinstein LS, Gao J, Yang J, Zhang Q, Zhang C, Zhang W. Stimulatory G-Protein α Subunit Modulates Endothelial Cell Permeability Through Regulation of Plasmalemma Vesicle-Associated Protein. Front Pharmacol. 2022;13:941064.

37.      He L, Lu H, Chu J, Qin X, Gao J, Chen M, Weinstein LS, Yang J, Zhang Q, Zhang C, Zhang W. Endothelial G protein stimulatory α-subunit is a critical regulator of post-ischemic angiogenesis. Front Cardiovasc Med. 2022;9:941946.

38.      Zhang Y, Yuan P, Ma X, Deng Q, Gao J, Yang J, Zhang T, Zhang C, Zhang W. Deletion of Smooth Muscle Lethal Giant Larvae 1 Promotes Neointimal Hyperplasia in Mice. Front Pharmacol. 2022;13:834296.

39.      Wu Z, Cui H, Li W, Zhang Y, Liu L, Liu Z, Zhang W, Zheng T, Yang J. Comparison of three non-insulin-based insulin resistance indexes in predicting the presence and severity of coronary artery disease. Front Cardiovasc Med. 2022;9:918359.

40.      Ma L, Yang J, Liu Y, Wang F, Liu T, Wang Y, Sun H, Zhang C, Zhang Y. Case report: Acute ST-elevation myocardial infarction and cardiogenic shock caused by a giant right sinus of Valsalva aneurysm and right coronary artery compression. Front Cardiovasc Med. 2022;9:1013044.

41.      Cai Q, Xing CY, Zhu J, Wang Y, Lu F, Peng J. Associations between triglyceride-glucose index and different hypertension subtypes: A population-based study in China. Front Cardiovasc Med. 2022;9:901180.

42.      Liu L, Wu Z, Zhuang Y, Zhang Y, Cui H, Lu F, Peng J, Yang J. Association of triglyceride-glucose index and traditional risk factors with cardiovascular disease among non-diabetic population: a 10-year prospective cohort study. Cardiovasc Diabetol. 2022;21:256.

43.      Liu S, Jiang X, Cui X, Wang J, Liu S, Li H, Yang J, Zhang C, Zhang W. Smooth muscle-specific HuR knockout induces defective autophagy and atherosclerosis. Cell Death Dis. 2021;12:385.

44.      Zhang J, Yang J, Liu L, Li L, Cui J, Wu S, Tang K. Significant abnormal glycemic variability increased the risk for arrhythmias in elderly type 2 diabetic patients. BMC Endocr Disord. 2021;21:83.

45.      Zhang C, Suo M, Liu L, Qi Y, Zhang C, Xie L, Zheng X, Ma C, Li J, Yang J, Bu P. Melatonin Alleviates Contrast-Induced Acute Kidney Injury by Activation of Sirt3. Oxid Med Cell Longev. 2021;2021:6668887.

46.      Zhang T, Li H, Ouyang C, Cao G, Gao J, Wu J, Yang J, Yu N, Min Q, Zhang C, Zhang W. Liver kinase B1 inhibits smooth muscle calcification via high mobility group box 1. Redox Biol. 2021;38:101828.

47.      Wu Z, Zhang W, Yang J. Letter by Wu et al Regarding Article, "Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis". Circulation. 2021;143:e919-e920.

48.      Tian M, Jiang X, Li X, Yang J, Zhang C, Zhang W. LKB1IP promotes pathological cardiac hypertrophy by targeting PTEN/Akt signalling pathway. J Cell Mol Med. 2021;25:2517-2529.

49.      Fang Y, Yang J, Zu G, Cong C, Liu S, Xue F, Ma S, Liu J, Sun Y, Sun M. Junctional Adhesion Molecule-Like Protein Promotes Tumor Progression and Metastasis via p38 Signaling Pathway in Gastric Cancer. Front Oncol. 2021;11:565676.

50.      Tian M, Wang J, Liu S, Li X, Li J, Yang J, Zhang C, Zhang W. Hepatic HuR protects against the pathogenesis of non-alcoholic fatty liver disease by targeting PTEN. Cell Death Dis. 2021;12:236.

51.      Cheng C, Xue F, Sui W, Meng L, Xie L, Zhang C, Yang J, Zhang Y. Deletion of natriuretic peptide receptor C alleviates adipose tissue inflammation in hypercholesterolemic Apolipoprotein E knockout mice. J Cell Mol Med. 2021;25:9837-9850.