学习与工作经历：

毕业于山东大学，美国伊利诺伊大学联合培养博士。从事普外科及腹腔镜外科工作10余年，现任普通外科主任助理、山东大学齐鲁医院副主任医师、副教授、硕士研究生导师，病理生理学博士后。

研究方向：

胃肠道良恶性肿瘤的临床、手术及耐药机制研究。

学术/社会兼职：

山东省医学会胃肠外科学组副组长；

山东省康复医学会消化道微创外科分会副主任委员；

山东省医药教育协会肿瘤干细胞与耐药专委会常务委员；

山东省医师协会肿瘤医师分会委员；

山东省研究型医院协会杰出青年学者分会委员；

山东省青年医务工作者协会会员；

Frontiers in surgery、Frontiers in Oncology客座编辑；

《腹腔外科杂志》编委。

获奖荣誉：

山东省科技进步二等奖（第二位）

本科生课程：

外科学

研究生课程：

腔镜外科学

1.D44107FD1D970AD2E053BE07C2CA0A82，中枢GLP-1调控Rab10及GLUTs 通路在袖状胃切除术后脑组织糖代谢及认知功能改善中的作用机制，山东省自然科学基金，10万，2022.01-2024.12，项目负责人。

2.十二指肠空肠旁路术后中枢GLP-1在糖尿病大鼠脑组织糖代谢及认知功能改善中的作用及机制研究，中国博士后基金，8万，2020.12-2022.11，项目负责人。

3.kyxm-62290，p18及Cdc42/PKCα介导VE-cadherin再循环调控内皮屏障功能的作用及机制研究，国家自然科学基金（青年基金），18万，2017.01-2019.12，项目负责人。

4.巨噬细胞NLRP3炎性体在胃旁路术后胰岛β细胞功能改善中作用机制研究，山东省自然科学基金，12万，2014.09-2017.09，项目负责人。

1.Yu A, Li Y, Zhang H, Hu G, Zhao Y, Guo J, Wei M, Yu W,Yan Z.Development and validation of a preoperative nomogram for predicting the surgical difficulty of laparoscopic colectomy for right colon cancer: a retrospective analysis. International Journal of Surgery. 2023; 109(4): p 870-878.

2.Ruze R, Xu Q, Liu G, Li Y, Chen W, Cheng Z, Xiong Y, Liu S, Zhang G, Hu S,Yan Z.Central GLP-1 contributes to improved cognitive function and brain glucose uptake after duodenum-jejunum bypass on obese and diabetic rats. American Journal of Physiology-Endocrinology and Metabolism. 2021 Sep 1;321(3):E392-409.

3.Liu Y, Liu J, Xu Q, Zhang B, Wang M, Zhang G,Yan Z.Objective follow-up after transection of uterine round ligament during laparoscopic repair of inguinal hernias in women: assessment of safety and long-term outcomes. Surgical Endoscopy. 2022 Jun;36(6):3798-804.

4.Xu B, Cheng Z, Zhi X, Yang X,Yan Z.Effect of p18 on endothelial barrier function by mediating vascular endothelial Rab11a-VE-cadherin recycling. Bioscience, Biotechnology, and Biochemistry. 2021 Dec;85(12):2392-403.

5.Xu Q, Zhang G, Li L, Xiang F, Qian L, Xu X,Yan Z.Non-closure of the free peritoneal flap during laparoscopic hernia repair of lower abdominal marginal hernia: a retrospective analysis. Frontiers in Surgery. 2021;8.

6.Yu A, Cheng Z, Bi D,Yan Z.Polymer-ligating clips used as line stoppers during closing the peritoneum of the pelvic floor. Techniques in Coloproctology. 2022 Feb;26(2):147-8.

7.Yan Z,Liu Y, Ruze R, Xiong Y, Han H, Zhan H, Wang M, Zhang G. Continuation of low-dose acetylsalicylic acid during perioperative period of laparoscopic inguinal hernia repair is safe: results of a prospective clinical trial. Hernia. 2019 Dec;23(6):1141-8.

8.Wu D,Yan Z, Cheng YG, Zhong MW, Liu SZ, Zhang GY, Hu SY. Deactivation of the NLRP3 inflammasome in infiltrating macrophages by duodenal-jejunal bypass surgery mediates improvement of beta cell function in type 2 diabetes. Metabolism. 2018 Apr 1;81:1-2.(Co-first author)

9.Yan Z, Zhang H, Zhan H, Wu D, Cheng Y, Wu Q, Zhang G. The modified laparoscopic keyhole parastomal hernia repair with in situ re-ostomy has low recurrence rate. Hernia. 2018 Aug;22(4):685-90.

10.Yan Z,Wang ZG, Segev N, Hu S, Minshall RD, Dull RO, Zhang M, Malik AB, Hu G. Rab11a mediates vascular endothelial-cadherin recycling and controls endothelial barrier function. Arteriosclerosis, thrombosis, and vascular biology. 2016 Feb;36(2):339-49.

11.Wu J,Yan Z,Schwartz DE, Yu J, Malik AB, Hu G. Activation of NLRP3 inflammasome in alveolar macrophages contributes to mechanical stretch-induced lung inflammation and injury. The Journal of Immunology. 2013 Apr 1;190(7):3590-9.(Co-first author)

12.Yan Z,Chen W, Liu S, Zhang G, Sun D, Hu S. Myocardial insulin signaling and glucose transport are up-regulated in Goto–Kakizaki type 2 diabetic rats after ileal transposition. Obesity surgery. 2012 Mar;22(3):493-501.

13.Cheng Z, Ren P, Wang X, Wang K,Yan Z, Bi D, Wang Y, Dai Y, Zhang X. Exploring Central Vascular Anatomy With Axial Computed Tomography During Surgery for Sigmoid Colon and Rectal Cancer: New Insights Into the Anatomical Relationship Between the Inferior Mesenteric Artery and the Duodenum. Frontiers in Surgery. 2021;8.

14.Wang M, Xiong Y, Zhu W, Ruze R, Xu Q,Yan Z,Zhu J, Zhong M, Cheng Y, Hu S, Zhang G. Sleeve Gastrectomy Ameliorates Diabetes-Related Spleen Damage by Improving Oxidative Stress Status in Diabetic Obese Rats. Obesity Surgery. 2021 Mar;31(3):1183-95.

15.Ruze R, Li J, Xu Q, Zhong M, Xiong Y,Yan Z,Zhu J, Cheng Y, Ma Z, Hu S, Zhang G. Sleeve gastrectomy ameliorates alveolar structures and surfactant protein expression in lungs of obese and diabetic rats. International Journal of Obesity. 2020 Dec;44(12):2394-404.

16.Yang X, Chen L, Li Y, Gao F,Yan Z,Zhang P, Wu J, Wang H, Sun B. Protective effect of Hydroxysafflor Yellow A on cerebral ischemia reperfusion-injury by regulating GSK3β-mediated pathways. Neuroscience Letters. 2020 Sep 25;736:135258.

17.Xiong Y, Zhu W, Xu Q, Ruze R,Yan Z, Li J, Hu S, Zhong M, Cheng Y, Zhang G. Sleeve gastrectomy attenuates diabetic nephropathy by upregulating nephrin expressions in diabetic obese rats. Obesity surgery. 2020 Aug;30:2893-904.

18.Gao C, Zeng R, Xiong Y, Ruze R,Yan Z, Zhang G. The Learning Curve for Laparoscopic Inguinal Hernia Repair: an Analysis of the First 109 Cases. Indian Journal of Surgery. 2020 Jul 16:1-7.

19.Ruze R, Yan Z,Wu Q, Zhan H, Zhang G. Correlation between laparoscopic transection of an indirect inguinal hernial sac and postoperative seroma formation: a prospective randomized controlled study. Surgical endoscopy. 2019 Apr;33(4):1147-54.

20.Yang Z, Sun D,Yan Z, Reynolds AB, Christman JW, Minshall RD, Malik AB, Zhang Y, Hu G. Differential role for p120-catenin in regulation of TLR4 signaling in macrophages. The Journal of Immunology. 2014 Aug 15;193(4):1931-41.

21.Wubulikasimu M, Haifeng H,Zhibo Y, Xiang Z, Shaozhuang L, Guangyong Z, Aimaiti K, Sanyuan H. Duodenal-jejunal bypass surgery on type 2 diabetic rats reduces the expression of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in the thoracic aorta. Chinese medical journal. 2014 Jul 5;127(13):2423-8.

22.Chen W,Yan Z, Liu S, Zhang G, Sun D, Hu S. The better effect of Roux-en-Y gastrointestinal reconstruction on blood glucose of nonobese type 2 diabetes mellitus patients. The American Journal of Surgery. 2014 Jun 1;207(6):877-81.

23.Jiao H, Zhang Y,Yan Z, Wang ZG, Liu G, Minshall RD, Malik AB, Hu G. Caveolin-1 Tyr14 phosphorylation induces interaction with TLR4 in endothelial cells and mediates MyD88-dependent signaling and sepsis-induced lung inflammation. The Journal of immunology. 2013 Dec 15;191(12):6191-9.

24.Sun D, Wang K,Yan Z, Zhang G, Liu S, Liu F, Hu C, Hu S. Duodenal–jejunal bypass surgery up-regulates the expression of the hepatic insulin signaling proteins and the key regulatory enzymes of intestinal gluconeogenesis in diabetic Goto–Kakizaki rats. Obesity surgery. 2013 Nov;23(11):1734-42.

25.Liu S, Zhang G, Wang L, Sun D, Chen W,Yan Z, Sun Y, Hu S. The entire small intestine mediates the changes in glucose homeostasis after intestinal surgery in Goto-Kakizaki rats. Annals of surgery. 2012 Dec 1;256(6):1049-58.

26.Sun D, Liu S, Zhang G, Chen W,Yan Z, Hu S. Type 2 diabetes control in a nonobese rat model using sleeve gastrectomy with duodenal–jejunal bypass (SGDJB). Obesity surgery. 2012 Dec;22(12):1865-73.

27.Liu D,Yan Z, Minshall RD, Schwartz DE, Chen Y, Hu G. Activation of calpains mediates early lung neutrophilic inflammation in ventilator-induced lung injury. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2012 Feb 15;302(4):L370-9.

28.Chen W,Yan Z, Liu S, Zhang G, Sun D, Hu S. The changes of pro-opiomelanocortin neurons in type 2 diabetes mellitus rats after ileal transposition: the role of POMC neurons. Journal of Gastrointestinal Surgery. 2011 Sep;15(9):1618-24.

29.Wei M, Liang Y, Wang L, Li Z, Chen Y,Yan Z,Sun D, Huang Y, Zhong X, Liu P, Yu W. Clinical application of indocyanine green fluorescence technology in laparoscopic radical gastrectomy. Frontiers in Oncology. 2022 Mar 4; 12:847341.

30.Liu C,Yan Z,Fang C, Cao G, Wang B, Li S, Wu S. Establishment and comparison of two reliable hyperkinetic pulmonary hypertension models in rabbits. The Journal of Thoracic and Cardiovascular Surgery. 2014 Nov 1;148(5):2353-9.

31.Zhang W, Liu S, Zhan H,Yan Z,Zhang G. Transcriptome sequencing identifies key pathways and genes involved in gastric adenocarcinoma. Molecular medicine reports. 2018 Oct 1;18(4):3673-82.

32.Ruze R, Xiong YC, Li JW, Zhong MW, Xu Q,Yan ZB, Zhu JK, Cheng YG, Hu SY, Zhang GY. Sleeve gastrectomy ameliorates endothelial function and prevents lung cancer by normalizing endothelin-1 axis in obese and diabetic rats. World Journal of Gastroenterology. 2020 May 5;26(20):2599.