学习与工作经历：

2000-2006，中国科学院植物研究所，博士

2006-2011，哈佛大学，博士后

2011-2015，哈佛大学，Research Associate

2015-至今，山东大学，教授，博士生导师

研究方向：

长期从事减数分裂及其异常导致的不孕不育分子机制的研究：发现女性特异的“交叉重组成熟缺陷”是导致高频率的染色体分离错误和非整倍体的根本原因；揭示染色体轴长变化调控减数分裂重组的新规律并阐明染色体轴长调控的分子通路；鉴定多个新的减数分裂重组调控因子并解析其作用机制。成果发表于Cell、Nature、PNAS等期刊。

学术/社会兼职：

中国生理学会生殖科学委员会理事，中国动物学会生殖生物学委员会理事，中国细胞学会发育生物学委员会委员，山东省细胞生物学学会常务理事

获奖荣誉：

国家高层次人才引进计划入选者，山东省杰出青年基金获得者

本科生课程：

研究生课程：

1. 2018YFC1003400，生殖细胞染色体行为的分子调控，科技部重点研发计划项目，2018–2021，3099万元，主持。

2. 31893078012，减数分裂DNA双链断裂修复途径和修复中间产物解体方式的选择调控，国家自然科学基金委，325万元，2019-2023，主持。 

3. 减数分裂，海外高层次人才青年项目，2015-2018，300万元，主持。

4. 3167080123，细胞大小对减数分裂重组频率的调节及其机制，国家自然科学基金委，2017-2020，60万元，主持。

5. 32070575，酿酒酵母拓扑异构酶II调控减数分裂交叉干涉的分子机制，国家自然科学基金委，2021-2024，60万元，主持。

6. JQ201605，减数分裂，山东省杰出青年基金，2016-2019，60万元，主持。

1. Shunxin Wang#*, Carl Veller#, Fei Sun, Aurora Ruiz-Herrera, Yongliang Shang, Hongbin Liu, Denise Zickler, Zijiang Chen, Nancy Kleckner*,Liangran Zhang*(2019) Per-nucleus crossover covariation and implications for evolution.Cell, 177(2):326-338.

2. Shunxin Wang, Terry Hassold, Patricia Hunt, Martin A White, Denise Zickler, Nancy Kleckner*,Liangran Zhang* (2017)Inefficient crossover maturation underlies elevated aneuploidy in human female meiosis.Cell168(6):977-989.e17.

3. Taicong Tan, Yingjin Tan, Ying Wang, Xiao Yang, Binyuan Zhai, Shuxian Zhang, Xuan Yang, Hui Nie, Jinmin Gao, Jun Zhou,Liangran Zhang*, Shunxin Wang*(2022). Negative supercoils regulate meiotic crossover patterns in budding yeast.Nucleic Acids Res.50(18):10418-10435.

4. Xiao Yang, Meihui Song, Ying Wang, Taicong Tan, ZHongyu Tian, Binyuan Zhai, Xuan Yang, Yingjin Tan, Yanding Cao, Shaojun Dai, Shunxin Wang,Liangran Zhang* (2022). The ubiquitin-proteasome system regulates meiotic chromosome organization.Proc Natl Acad Sci USA.119(17):e2106902119.

5. Xuan Yang#, Binyuan Zhai#, Shunxin Wang#, Xiangfei Kong, Yingjin Tan, Lin Liu, Xiao Yang, Taicong Tan, Shuxian Zhang,Liangran Zhang* (2021)RNA-DNA hybrids regulate meiotic recombination.Cell Reports, 37(10): 110097.

6. Meihui Song, Binyuan Zhai, Xiao Yang, Taicong Tan, Ying Wang, Xuan Yang, Yingjin Tan, Tingting Chu, Yanding Cao, Yulong Song, Shunxin Wang,Liangran Zhang* (2021)Interplay between Pds5 and Rec8 in regulating chromosome axis length and crossover frequency.Sci Adv.7(11):eabe7920.

7. Ying Wang, Binyuan Zhai, Taicong Tan, Xiao Yang, Jiaming Zhang, Meihui Song, Yingjin Tan, Xuan Yang, Tingting Chu, Shuxian Zhang, Shunxin Wang,Liangran Zhang*(2021)ESA1 regulates meiotic chromosome axis and crossover frequency via acetylating histone H4.Nucleic Acids Res. 49(16):9353-9373.

8. Yongliang Shang#, Tao Huang#, Hongbin Liu, Yanlei Liu, Heng Liang, Xiaoxia Yu, Mengjing Li, Binyun Zhai, Xiao Yang, Yudong Wei, Guoqiang Wang, Zijiang Chen*, Shunxin Wang*,Liangran Zhang*(2020) MEIOK21: a new component of meiotic recombination bridges required for spermatogenesis.Nucleic Acids Res. 48(12):6624-6639.

9. Liangran Zhang, Shunxin Wang, Shen Yin, Soogil Hong, Keun P. Kim, Nancy Kleckner* (2014) Topoisomerase II mediates meiotic crossover interference.Nature511: 551–556.

10. Liangran Zhang, Eric Espagne, Arnaud De Muyt, Denise Zickler, Nancy Kleckner* (2014) Interference-mediated synaptonemal complex formation with embedded crossover-designation.Proc Natl Acad Sci USA111(47):E5059-68.

11. Arnaud De Muyt#,Liangran Zhang#, Tristan Piolot, Nancy Kleckner, Eric Espagne* and Denise Zickler* (2014) E3 ligase Hei10: a multi-faceted structure-based signaling molecule with roles within and beyond meiosis.Genes Dev28: 1111-1123.

12. Liangran Zhang, Keun P Kim, Nancy E Kleckner*, Aurora Storlazzi* (2011) Meiotic double-strand breaks occur once per pair of (sister) chromatids and, via Mec1/ATR and Tel1/ATM, once per quartet of chromatids.Proc Natl Acad Sci USA. 108(50):20036–20041.