学习与工作经历：

1996-2000      山东大学生命科学学院，生物技术专业，学士

2000-2003      山东大学生命科学学院，微生物学专业，硕士

2007-2011      山东大学医学院，病原生物学专业，博士

2003-2005      助教，山东大学基础医学院

2005-2011      讲师，山东大学基础医学院

2011-2020      副教授，山东大学基础医学院

2020-至今      教授，山东大学基础医学院

研究方向：

肾脏损伤机制与干预策略

学术/社会兼职：

中国药理学会肾脏药理专业委员会委员

获奖荣誉：

本科生课程：

医学微生物学

研究生课程：

现代医学微生物学、医学分子病毒学与细菌学

1. 182270718，肾脏损伤修复的新机制：Bud31介导的可变剪接重编程，国家自然科学基金（面上项目），2023.01-2026.12,53万，项目负责人

2. 81970580，ISG20介导的氧化RNA降解在急性肾损伤中的作用与机制，国家自然科学基金（面上项目），2020.01-2024.12，53万，项目负责人

3. 81670629，p204/IFI16介导的免疫调控在急性肾损伤中的作用与机制，国家自然科学基金（面上项目），2017.01-2020.12，62万，项目负责人

4. 81102229，生长因子Progranulin结合TNFR2的关键氨基酸鉴定与结合模式分析，国家自然科学基金（青年基金项目），2012.01-2014.12，28万，项目负责人

1. Liu F*, Wei B, Xu X, Ma B, Zhang S, Duan J, Kong Y, Yang H, Sang Y, Wang S, Tang W#, Liu C#, Liu H#. Nanocellulose-Reinforced Hydroxyapatite Nanobelt Membrane as a Stem Cell Multi-Lineage Differentiation Platform for Biomimetic Construction of Bioactive 3D Osteoid Tissue In Vitro. Adv Healthc Mater. 2021 Apr;10(8):e2001851.

2. Zhou D*, Zhou M*, Wang Z, Fu Y, Jia M, Wang X, Liu M, Zhang Y, Sun Y, Zhou Y, Lu Y, Tang W#, Yi F#. Progranulin alleviates podocyte injury via regulating CAMKK/AMPK-mediated autophagy under diabetic conditions. J Mol Med (Berl). 2019 Nov;97(11):1507-1520.

3. Zhou D*, Zhou M, Wang Z, Fu Y, Jia M, Wang X, Liu M, Zhang Y, Sun Y, Lu Y, Tang W#, Yi F#. PGRN acts as a novel regulator of mitochondrial homeostasis by facilitating mitophagy and mitochondrial biogenesis to prevent podocyte injury in diabetic nephropathy. Cell Death Dis. 2019 Jul 8;10(7):524.

4. Baojin Ma*, Feng Liu, Shan Zhang, Jiazhi Duan, Ying Kong, Zhao Li, Dongqi Tang, Wenjuan Wang, Shaohua Ge#, Wei Tang#, Hong Liu#. Two-photon fluorescent polydopamine nanodots for CAR-T cell function verification and tumor cell/tissue detection. J. Mater. Chem. B, 2018, 6, 6459-6467.

5. Li X*, Zuo Z, Chen Q, Li J, Tang W#, Yang P#. Progranulin is highly expressed in patients with chronic periodontitis and protects against experimental periodontitis in rats. J Periodontol. 2018 Dec;89(12):1418-1427.

6. Ma B*, Zhang S, Liu F, Duan J, Wang S, Han J, Sang Y, Yu X, Li D, Tang W#, Ge S#, Liu H#. One-Dimensional Hydroxyapatite Nanostructures with Tunable Length for Efficient Stem Cell Differentiation Regulation. ACS Appl Mater Interfaces. 2017 Oct 4;9(39):33717-33727.

7. Zhou M*, Tang W*, Fu Y, Xu X, Wang Z, Lu Y, Liu F, Yang X, Wei X, Zhang Y, Liu J, Geng X, Zhang C, Wan Q, Li N, Yi F#. Progranulin protects against renal ischemia/reperfusion injury in mice. Kidney Int. 2015 May;87(5):918-29.

8. Feng T*, Zheng L*, Liu F, Xu X, Mao S, Wang X, Liu J, Lu Y, Zhao W, Yu X, Tang W#. Growth factor progranulin promotes tumorigenesis of cervical cancer via PI3K/Akt/mTOR signaling pathway. Oncotarget. 2016 Sep 6;7(36):58381-58395.

9. Yu Y*, Xu X, Liu L, Mao S, Feng T, Lu Y, Cheng Y, Wang H, Zhao W, Tang W#. Progranulin deficiency leads to severe inflammation, lung injury and cell death in a mouse model of endotoxic shock. J Cell Mol Med. 2016 Mar;20(3):506-17.

10. Xu X*, Gou L, Zhou M, Yang F, Zhao Y, Feng T, Shi P, Ghavamian A, Zhao W, Yu Y, Lu Y, Yi F, Liu G#, Tang W#. Progranulin protects against endotoxin-induced acute kidney injury by downregulating renal cell death and inflammatory responses in mice. Int Immunopharmacol. 2016 Sep;38:409- 419.

11. Lu Y*, Zheng L, Zhang W, Feng T, Liu J, Wang X, Yu Y, Qi M, Zhao W, Yu X#, Tang W#. Growth factor progranulin contributes to cervical cancer cell proliferation and transformation in vivo and in vitro. Gynecol Oncol. 2014 Aug;134(2):364-71.

12. Zheng L*, Tang W*, Wei F, Wang H, Liu J, Lu Y, Cheng Y, Bai X, Yu X#, Zhao W#. Radiation-inducible protein RbAp48 contributes to radiosensitivity of cervical cancer cells. Gynecol Oncol. 2013 Sep;130(3):601-8.

13. Tang W*, Lu Y*, Tian QY*, Zhang Y, Guo FJ, Liu GY, Syed NM, Lai Y, Lin EA, Kong L, Su J, Yin F, Ding AH, Zanin-Zhorov A, Dustin ML, Tao J, Craft J, Yin Z, Feng JQ, Abramson SB, Yu XP, Liu CJ#. The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science. 2011 Apr 22;332(6028):478-84.