学习与工作经历：

2005.09-2009.06 山东大学 生命科学学院 学士

2009.09-2015.07 中国科学院 上海生物化学与细胞生物学研究所 博士

2015.07-2018.03 武汉大学 生命科学学院 博士后

2018.03-2022.07 美国杰克森实验室（The Jackson Laboratory） 博士后

2022.09-今 山东大学 基础医学院 研究员 齐鲁青年学者

研究方向：

代谢过程对T细胞抗肿瘤免疫活性的调控

结合糖脂代谢与T细胞代谢调控的研究基础，聚焦代谢与免疫调节交叉领域，探索肿瘤微环境代谢变化在 T细胞耗竭中的作用与机制；以相关代谢通路为靶标，发展提高T细胞免疫活性的新方法。从糖脂代谢的角度探索肿瘤浸润T细胞免疫抑制的机理，研究成果有助于优化肿瘤免疫疗法。

学术/社会兼职：

山东免疫学会基础免疫专业委员会委员

Frontiers in Immunology杂志Review Editor

Frontiers in Oncology杂志 Review Editor

Cancer and Metastasis Reviews杂志审稿人

获奖荣誉：

泰山学者（青年专家）

山东省优秀青年科学基金(海外)

本科生课程：

生理学、人体结构与功能、生理学实验

研究生课程：

8237175，丙酮酸代谢命运对肿瘤浸润T细胞耗竭的调控与机制，国家自然科学基金，2024.01-2027.12，49万，主持

2023HWYQ-036，脂代谢与肿瘤免疫代谢调控，山东省优秀青年科学基金项目（海外），2023.01-2025.12, 60万，主持

Tsqn202312082,泰山学者（青年专家）项目，2024.01-2026.12, 37.5万，主持

21510082263061,山东大学齐鲁青年学者，山东大学，2022.09-2027.08，100万，主持

31601147, VPS53调控细胞内胆固醇转运的机制与生理功能，国家自然科学基金，2017.01-2019.12，18万，主持

ZR2023MH163, T细胞-嗜碱性粒细胞互作在肿瘤免疫中的效应及代谢调控，山东省自然科学基金，2024.01-2026.12,10万，主持

1.Jian Wei^#, Yingyu Zhang^#, Jie Luo, Juqiong Wang, Yuxia Zhou, Honghua Miao, Xiongjie Shi, Yuxiu Qu, Jie Xu, Boliang Li, Baoliang Song*, The GARP complex is involved in intracellular cholesterol transport via targeting NPC2 to lysosomes,Cell Reports, 2017, 19: 2823–2835. (^#first author, *corresponding author)

2.Yingyu Zhang^#, Zhenyan Fu^#,Jian Wei^#, Wei Qi, Gulinaer Baituola, Jie Luo, Yajie Meng, Shuyuan Guo, Huiyong Yin, Shiyou Jiang, Yunfeng Li, Honghua Miao, Yong Liu, Yan Wang, Boliang Li, Yitong Ma*, Baoliang Song*, A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption,Science, 2018, 360 (6393): 1087-1092.(^#first author, *corresponding author)

3.John J Wilson^#,Jian Wei^#,Andrea R Daamen^#,John D Sears,Elaine Bechtel,Colleen L Mayberry,Grace A Stafford,Lesley Bechtold,Amrie C Grammer,Peter E Lipsky,Derry C Roopenian,Chih-Hao Chang*,Glucose oxidation-dependent survival of activated B cells provides a putative novel therapeutic target for lupus treatment,iScience, 2023,26, 107487. (^#first author, *corresponding author)

4.Yacheng Liao^#,Jian Wei^#, Juqiong Wang, Xiongjie Shi, Jie Luo, Baoliang Song*,The non-canonical NF-κB pathway promotes NPC2 expression and regulates intracellular cholesterol trafficking,Science China Life Sciences, 2018, 61(10): 1222-1232. (^#first author, *corresponding author)

5.Xuemin Gong^#, Yunfeng Li^#, Jie Luo^#, Jiqiu Wang^#,Jian Wei^#, Juqiong Wang, Ting Xiao, Chang Xie, Jie Hong, Guang Ning, Xiongjie Shi, Boliang Li, Wei Qi *, Baoliang Song*, Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance,Nature Metabolism, 2019, 1:570-583. (^#first author, *corresponding author)

6.Jian Wei^#, Zhenyan Fu^#, Peishan Li^#, Honghua Miao, Boliang Li, Yitong Ma*, Baoliang Song*, The clathrin adaptor proteins ARH, Dab2, and numb play distinct roles in Niemann-Pick C1-Like 1 versus low density lipoprotein receptor-mediated cholesterol uptake,Journal of Biological Chemistry, 2014, 289 (48): 33689-33700. (^#first author, *corresponding author)

7.魏健，江路易，宋保亮，胆固醇的内源合成与小肠吸收，生命科学，2015，(07)：847-858.

8.Ju-Qiong Wang^#, Liang-Liang Li,Jian Wei, Yun-Feng Li, Xiao-Yi Lu, Zhi-Ping Qiu, Xiong-Jie Shi, Jie Luo, Bao-Liang Song*, Inhibition ofESFCR1decreases lipid levels by promoting cholesterol excretion,Nature,2022, 608(7922):413-420. (^#first author, *corresponding author)

9.Zheng Gong^#,Qing Li^#,Jiayuan Shi,Jian Wei,Peishan Li,Chih-Hao Chang,Leonard D Shultz,Guangwen Ren*, Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment,Immunity,2022 Aug 9;55(8):1483-1500.(^#first author, *corresponding author)

10.Yu-Xia Zhou^#,Jian Wei,Gang Deng,Ao Hu,Pu-Yu Sun,Xiaolu Zhao,Bao-Liang Song*,Jie Luo*, Delivery of low-density lipoprotein from endocytic carriers to mitochondria supports steroidogenesis,Nature Cell Biology,2023, 25: 937–949.(^#first author, *corresponding author)

11.Jie Gao^#, Yanbo Liu,Jian Wei, Linlan Jiang, Jianwen Mao, Chih-Hao Chang*, Duojiao Wu*,Targeting T cell metabolism for immunotherapy,Journal of Leukocyte Biology, 2021, 110:1081-1090.(^#first author, *corresponding author)

12.John D. Sears^#, Kevin J. Waldron,Jian Wei, Chih-Hao Chang*,Targeting metabolism to reverse T-cell exhaustion in chronic viral infections,Immunology, 2020,162: 135–144.(^#first author, *corresponding author)

13.Shuaiya Ma^#,Qi Wu^#,Wenxian Wu^#,Ye Tian,Jie Zhang,Chaojia Chen,Xue Sheng,Fangcheng Zhao,Lu Ding,Taixia Wang,Laixi Zhao,Yuying Xie,Yongxiang Wang,Xuetian Yue,Zhuanchang Wu,Jian Wei,Kun Zhang,Xiaohong Liang,Lifen Gao,Hongyan Wang,Guihua Wang*,Chunyang Li*,Chunhong Ma*, Urolithin A hijacks ERK1/2-ULK1 cascade to improve CD8+T cell fitness for antitumor immunity,Advanced Science, 2024, 2310065.(^#first author, *corresponding author)

14.Dilare Adi^#, Xiaoyi Lu^#, Zhenyan Fu^#,Jian Wei, Gulinaer Baituola, Yajie Meng, Yuxia Zhou, Ao Hu, Jinkai Wang, Xiangfeng Lu, Yan Wang, Baoliang Song, Yitong Ma*, Jie Luo*, IDOL G51S variant is associated with high blood cholesterol and increases low-density lipoprotein receptor degradation,Arteriosclerosis, Thrombosis, and Vascular Biology, 2019, 39:2468–2479. (^#first author, *corresponding author)

15.Luyi Jiang^#, Wei Jiang^#, Na Tian, Yanni Xiong, Jie Liu,Jian Wei, Kaiyue Wu, Jie Luo, Xiongjie Shi, Baoliang Song*,Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase,Journal of Biological Chemistry, 2018, 293: 4047-4055. (^#first author, *corresponding author)

16.Jinfeng Su^#,Jian Wei, Peishan Li, Honghua Miao, Yongchao Ma, Yuxiu Qu, Jie Xu, Jie Qin, Boliang Li, Baoliang Song, Zhengping Xu*, Jie Luo*, Numb directs the subcellular localization of EAAT3 through binding the YxNxxF motif,Journal of Cell Science, 2016, 129 (16): 3104-3114. (^#first author, *corresponding author)

17.Qinghua Yuan^#, Zhenyan Fu,Jian Wei, Peishan Li, Honghua Miao, Yuxiu Qu, Jie Xu, Jie Qin, Boliang Li, Baoliang Song, Yitong Ma*, Identification and characterization of NPC1L1 variants in Uygur and Kazakh with extreme low-density lipoprotein cholesterol,Biochemical and Biophysical Research Communications, 2016, 479 (4): 628-635. (^#first author, *corresponding author)