学习与工作经历：

2006/9 - 2011/6，山东大学，生理学，博士，导师：郝爱军

2000/9 - 2003/6，山东大学，生理学，硕士，导师：陈连璧

1993/9 - 1998/6，新乡医学院，临床医学，学士

2014/9 - 至今，山东大学，医学院，副教授

2016/2 - 2017/1，美国肯塔基大学，医学院，访问学者

2011/11 - 2014/10, 山东大学，医学院，博士后，已出站

2008/8 - 2009/12，美国肯塔基大学，医学院Gill Heart心脏病研究所，访问学者

2005/9 - 2014/8，山东大学，医学院，讲师

研究方向：

中枢神经系统损伤及功能康复的研究。

学术/社会兼职：

获奖荣誉：

本科生课程：

生理学，人体结构与功能，生理学实验，医学机能学实验

研究生课程：

神经系统疾病基础与临床

1. 国家自然科学基金（面上项目）：82271327, M1区神经元激活释放的EVs介导miR-100-5p motif/TLR7在缺血性脑卒中的作用及机制研究，2023.01-2026.12，52万，在研，主持。

2. 国家自然科学基金（面上项目）：82072535，基于小胶质细胞OPN/CTSB/NLRP3轴介导的炎症反应探讨H2S促进缺氧缺血性脑损伤后神经功能重建的机制研究，2021.01-2024.12，55万，在研，主持。

3. 国家自然科学基金（面上项目）：81873768，H2S调控BMSCs外泌体相关miR-9/TN-C轴对HIBD后的神经保护作用及机制研究，2019.01-2022.12，56万，在研，主持。

4. 国家自然科学基金（面上项目）：81671213，利用条件基因敲除技术研究内源性H2S调控Shh通路对HIBD后新生小鼠海马神经再生的影响，2017.01-2020.12，57万，已结题，主持。

5. 山东省重点研发计划项目：2017GSF218091，左旋半胱氨酸调控Sonic Hedgehog通路对SAH大鼠及患者后认知功能障碍的影响及临床应用初探，2018.01-2019.12，10万，已结题，主持。

6. 山东大学基本科研业务费（交叉学科培育）项目：2015JC008，左旋半胱氨酸在脑出血后认知障碍中的临床应用及机制研究，2015.01-2017.12，35万，已结题，主持。

7. 中国博士后科学基金特别资助，2013T60672，硫化氢对缺血缺氧性脑损伤神经系统发育的影响及机制，2013.07-2015.07，15万，已结题，主持。

8. 国家自然科学基金（青年科学基金项目），81200879，饱和脂肪酸对胚胎神经系统发育的影响及机制研究，2013年01月- 2015年12月，23万，已结题，主持。

9. 山东大学自主创新基金：IIFSDU2012TS120，硫化氢对神经干细胞增殖分化的影响及其机制研究，2013.01-2015.12，7万，已结题，主持。

10. 中国博士后科学基金面上资助，2012M511514，孕期肥胖对胚胎神经系统发育的影响及机制研究，2012.05-2013. 12，5万，已结题，主持。

11. 山东省自然科学基金（青年项目），ZR2011HQ035，清道夫受体CD36在脂肪组织脂类代谢和炎症反应中的作用及机制的研究，2011.07-2014.07，5万，已结题，主持。

【通讯作者论文】

1. Ke Hongfei, Yang Hongru, Zhao Yijing, Li Tingting, Xin Danqing, Gai Chengcheng, Jiang Zige,Wang Zhen*（王贞）. 3D Gelatin Microsphere Scaffolds Promote Functional Recovery after Spinal Cord Hemisection in Rats. Advanced Science (Weinh). 2023 Jan;10(3):2204528.(IF 16.7).PubMed

2.Jiang Zige^#, Wang Wenhan^#, Zhao Yijing, Li Tingting, Xin Danqing, Gai Chengcheng, Liu Dexiang*,Wang Zhen*（王贞）, Mitochondria-targeted cerium vanadate nanozyme suppressed hypoxia-ischemia injury in neonatal mice via intranasal administration. Journal of Controlled Release.2024 Jan;365:1074-1088.(IF 10.2).PubMed

3. Chu Xili, Liu Dexiang, Li Tingting, Ke HongFei, Xin Danqing, Wang Shuhan, Cao Ying, Xue Hao,Wang Zhen*（王贞）. Hydrogen sulfide-modified extracellular vesicles from mesenchymal stem cells for treatment of hypoxic-ischemic brain injury.Journal of Controlled Release. 2020 December, 328 (10); 13-27.PubMed(IF 10.413).

4. Xin Danqing, Li Tingting, Chu Xili, Ke Hongfei, Yu Zhuoya, Cao Lili, Bai Xuemei, Liu Dexiang,Wang Zhen*（王贞）. Mesenchymal stromal cell-derived extracellular vesicles modulate microglia/macrophage polarization and protect the brain against hypoxia-ischemic injury in neonatal mice by targeting delivery of miR-21a-5p.Acta Biomaterialia. 2020 Sep 1; 113:597-613.PubMed(IF 9.000).

5.Yu Shuwen, Zhao Yijing, Luo Qian, Gu Bing, Wan Xixi, Cheng Jiao,Wang Zhen*（王贞）, Liu Dexiang*, Roger C.M. Ho, Cyrus S.H. Ho. Early life stress enhances the susceptibility to depression and interferes with neuroplasticity in the hippocampus of adolescent mice via regulating miR-34c-5p/SYT1 axis. Journal of Psychiatric Research.2024 Feb;170:262-276.PubMed

6. Zhao Yijing^#, Li Tong^#, Jiang Zige, Gai Chengcheng, Yu Shuwen, Xin Danqing, Li Tingting, Liu Dexiang*,Wang Zhen*（王贞）, The miR-9-5p/CXCL11 pathway is a key target of hydrogen sulfide-mediated inhibition of neuroinflammation in hypoxic ischemic brain injury. Neural Regeneration Research. 2024 May;19(5):1084-1094.(IF 5.1).PubMed

7. Li Tingting^#, Yuan Lin^#, Zhao Yijing, Jiang Zige, Gai Chengcheng, Xin Danqing, Ke Hongfei, Guo Xiaofan, Chen Wenqiang, Liu Dexiang*,Wang Zhen*（王贞）, Cyrus S H Ho. Blocking osteopontin expression attenuates neuroinflammation and mitigates LPS-induced depressive-like behavior in mice. Journal of Affective Disorders. 2023 Feb 24;330:83-93.(IF 6.3).PubMed

8. Gai Chengcheng, Zhao Yijing, Xin Danqing, Li Tingting, Cheng Yahong, Jiang Zige, Yan Song, Liu Dexiang*,Wang Zhen*（王贞）, Mechanistic Insights into the Role of OPN in Mediating Brain Damage via Triggering Lysosomal Damage in Microglia/Macrophage. Cells.2023 Mar 9;12(6):854.(IF 6.7).PubMed

9. Gai Chengcheng^#, Xing Xiaohui^#, Song Yan, Zhao Yijing , Jiang Zige , Cheng Yahong, Xiao Yilei*,Wang Zhen*（王贞）.Up-Regulation of miR-9-5p Inhibits Hypoxia-Ischemia Brain Damage Through the DDIT4-Mediated Autophagy Pathways in Neonatal Mice.Drug Design Development and Therapy. 2023 Apr 21;17:1175-1189.(IF 5.0).PubMed

10. Xin Danqing, Zhao Yijing, Li Tingting, Ke Hongfei, Gai Chengcheng, Guo Xiaofan, Chen Wenqiang, Liu Dexiang*,Wang Zhen*（王贞）. The delivery of miR-21a-5p by extracellular vesicles induces microglial polarization via the STAT3 pathway following hypoxia-ischemia in neonatal mice. Neural Regeneration Research. 2022 Oct;17(10):2238-2246.(IF 5.1).PubMed

11.Li Tingting ,Xin Danqing ,Ke Hongfei, Chu Xili, Zhao Yijing, Yue Shouwei, Liu Dexiang*,Wang Zhen*（王贞）.L-Cysteine attenuates osteopontin-mediated neuroinflammation following hypoxia-ischemia insult in neonatal mice by inducing S-sulfhydration of Stat3.Acta Pharmacologica Sinica.2022 Jul;43(7):1658-1669.(IF 8.2).PubMed

12.Xin Danqing, Li Tingting, Chu Xili, Ke Hongfei, Liu Dexiang,Wang Zhen*（王贞）. MSCs-extracellular vesicles attenuated neuroinflammation, synapse damage and microglial phagocytosis after hypoxia-ischemia injury by preventing osteopontin expression.Pharmacological Research. 2021 Feb; 164:105322.PubMed(IF 8.8).

13. Li Tingting, Chu Xili, Xin Danqing, Ke Hongfei, Wang Shuhan, Liu Dexiang, Chen Wenqiang,Wang Zhen*（王贞）. H₂S prevents peripheral immune cell invasion, increasing [Ca²⁺]i and excessive phagocytosis following hypoxia-ischemic injury in neonatal mice.  Biomedicine & Pharmacotherapy. 2021 Mar;135:111207.PubMed(IF 6.8).

14. Han Min, Cao Ying, Guo Xiaofan, Chu Xili, Li Tingting, Xue Hao, Xin Danqing, Yuan Lin, Ke Hongfei, Gang Li*,Wang Zhen*（王贞）. Mesenchymal stem cell-derived extracellular vesicles promote microglial M2 polarization after subarachnoid hemorrhage in rats and involve the AMPK/NF-κB signaling pathway. Biomedicine & Pharmacotherapy.2021 Jan; 133:111048.PubMed(IF 6.8).

15. Li Tingting^#, Li Jiangbing^#, Li Tong^#, Zhao Yijing, Ke Hongfei, Wang Shuanglian, Liu Dexiang*, andWang Zhen**（王贞）. L-Cysteine provides neuroprotection of hypoxia-ischemia injury in neonatal mice via a PI3K/Akt-dependent mechanism.Drug Design Development and Therapy.2021 Feb 11; 15:517-529.PubMed(IF 5.0).

16. Yin Sen^#, Bai Xuemei^#, Xin Danqing, Li Tingting , Chu Xili, Ke Hongfei, Han Min, Chen Wenqiang, Li Xingang*,Wang Zhen*（王贞）Neuroprotective Effects of the Sonic Hedgehog Signaling Pathway in Ischemic Injury through Promotion of Synaptic and Neuronal Health. Neural Plasticity. 2020 Aug 1; 2020:8815195.PubMed

17. Liu Dexiang^#, Bai Xuemei^#, Ma Weiwei, Xin Danqing, Chu Xili, Yuan Hongtao, Qiu Jie, Ke Hongfei,Yin Sen,Chen Wenqiang,Wang Zhen*（王贞）. Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling. Frontiers in Pharmacology. 2020 Mar 4; 11:204.PubMed(IF 6.005).

18. Han Min^#, Liu Dexiang^#, Qiu Jie, Yuan Hongtao, Hu Quan, Xue Hao, Li Tingting, Ma Weiwei, Zhang Qiong, Li Gang*,Wang Zhen*（王贞）. Evaluation of H₂S-producing enzymes in cerebrospinal fluid and its relationship with interleukin-6 and neurologic deficits in subarachnoid hemorrhage. Biomedicine & Pharmacotherapy. 2020 Mar; 123:109722.PubMed(IF 5.979).

19. Xiong Ye^#, Xin Danqing^#, Hu Quan^#, Wang Lingxiao, Qiu Jie, Yuan Hongtao, Chu Xinli, Liu Dexiang, Li Gang*,Wang Zhen*（王贞）. Neuroprotective Mechanism of L-cysteine After Subarachnoid Hemorrhage. Neural Regeneration Research. 2020 Oct; 15(10):1920-1930.PubMed(IF 3.983).

20. Han Min, Cao Ying, Xue Hao, Chu Xili, Li Tingting, Xin Danqing, Yuan Lin, Ke Hongfei, Li Gang*, andWang Zhen*（王贞）. Neuroprotective Effect of Mesenchymal Stromal Cell-Derived Extracellular Vesicles Against Cerebral Ischemia-Reperfusion-Induced Neural Functional Injury: A Pivotal Role for AMPK and JAK2/STAT3/NF-κB Signaling Pathway Modulation. Drug Design Development and Therapy. 2020 Jul 20; 14:2865-2876.PubMed(IF 4.278).

21.Ke Hongfei^#, LiuDexiang^#, Li Tingting , Chu Xili, Xin Danqing, Han Min, Wang Shuanglian,Wang Zhen*（王贞）.Hydrogen-Rich Saline Regulates Microglial Phagocytosis and Restores Behavioral Deficits Following Hypoxia-Ischemia Injury in Neonatal Mice via the Akt Pathway. Drug Design Development and Therapy. 2020 Sep 21; 14:3827-3839.PubMed(IF 4.278).

22. Chu Xili, Cao Lili, Yu Zhuoya, Xin Danqing, Li Tingting, Ma Weiwei, Zhou Xin,Chen Wenqiang, Liu Dexiang,Wang Zhen*（王贞）. Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation. Journal of Neuroinflammation. 2019 May 18; 16(1):104.PubMed(IF 6.162).

23. Zhou Xin^#, Chu Xili^#, Xin Danqng, Li Tingting, Bai Xuemei, Qiu Jie, Yuan Hongtao, Liu Dexiang, Wang Dachuan,Wang Zhen*（王贞）. L-Cysteine-Derived H₂S Promotes Microglia M2 Polarization via Activation of the AMPK Pathway in Hypoxia-Ischemic Neonatal Mice.Frontier in Molecular Neuroscience.2019 March 11; 12:58.PubMed(IF 4.351).

24 Yang Chunlei^#, Tong Li^#, Xue Hao, Wang Lingxiao, Deng Lin, Xie Yunkai, Bai Xuemei, Xin Danqing, Yuan Hongtao, Qiu Jie,Wang Zhen *（王贞）, Gang Li*. Inhibition of Necroptosis Rescues SAH-Induced Synaptic Impairments in Hippocampus via CREB-BDNF Pathway.Frontier in Neuroscience.2019 January 7;12:990.PubMed(IF 4.229).

25.Li Jiangbing,Xue Hao,Li Tingting,Chu Xili,Xin Danqing,Xiong Ye,Qiu Wei,Gao Xiao,Qian Mingyu,Xu Jiangye,Wang Zhen*（王贞）,Li Gang*. Exosomes derived from mesenchymal stem cells attenuate the progression of atherosclerosis in ApoE-/- mice via miR-let7 mediated infiltration and polarization of M2 macrophage.Biochemical and Biophysical Research Communications.2019 March 19:565-572.PubMed(IF 2.750).

26. Xie Yunkai^#, Zhou Xin^#, Yuan Hongtao, Qiu Jie, Xin Danqing, Chu Xili, Wang Dachuan*,Wang Zhen*（王贞）.Resveratrol reduces brain injury after subarachnoid hemorrhage by inhibiting oxidative stress and endoplasmic reticulum stress.Neural Regeneration Research. 2019 Oct; 14(10):1734-1742.PubMed(IF 2.637).

27. Xin Danqing, Chu Xili, Bai Xuemei, Ma Weiwei, Yuan Hongtao, Qiu Jie, Changxing Liu, Tong Li, Xin Zhou, Wenqiang Chen, Liu Dexiang,Wang Zhen*（王贞）. L-Cysteine suppresses hypoxia-ischemia injury in neonatal mice by reducing glial activation, promoting autophagic flux and mediating synaptic modification via H₂S formation. Brain Behavior and Immunity. 2018 October; 73:222-234.PubMed(IF 6.616).

28. Liu Song, Xin Danqing, Wang Lingxiao, Zhang Tiantian, Bai Xuemei, Li Tong, Xie Yuankai, Xue Hao, Bo Shishi, Liu Dexiang,Wang Zhen*（王贞）. Therapeutic effects of L-Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H₂S system: role of oxidative stress and endoplasmic reticulum stress. Redox Biology.2017 July 14; 13:528-540.PubMed(IF 7.613).

29. Li Tong^#, Wang Lingxiao^#, Hu Quan, Liu Song, Bai Xuemei, Xie Yuankai, Zhang Tiantian, Bo Shishi, Gao Xiangqian, Wu Shuhua, Li Gang*,Wang Zhen*（王贞）.Neuroprotective Roles of L-Cysteine in Attenuating Early Brain Injury and Improving Synaptic Density via the CBS/H₂S Pathway Following Subarachnoid Hemorrhage in Rats.Frontiers in Neurology. 2017 May 2; 8:176.PubMed(IF 4.297).

30. Ge Li, Wei Lihua, Du Changqing, Song Guohua, Xue Yazhuo, Shi Haoshen, Yang Ming, Yin Xinxin, Li Runting, Wang Xueer,Wang Zhen*（王贞）, Song Wengang*.Hydrogen-rich saline attenuates spinal cord hemisection-induced testicular injury in rats.Oncotarget. 2017 June 27; 8(26):42314-42331PubMed(IF ).

31. Hu Quan^#,Li Tong^#, Wang Lingxiao, Xie Yunkai, Liu Song, Bai Xuemei, Zhang Tiantian, Bo Shishi, Xin Danqing, Xue Hao,Li Gang*,Wang Zhen*（王贞）.Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats. Frontiers in Cellular Neuroscience. 2017 Januarly 18; 10:306PubMed(IF 4.915).

32.Li Tong,Liu Hansen,Xue Hao,Zhang Jinsen,Han Xiao,Yan Shaofeng,Bo Shishi,Liu Song,Yuan Lin,Deng Lin,Li Gang*,Wang Zhen*（王贞）. Neuroprotective effects of hydrogen sulfide against early brain injury and secondary cognitive deficits following subarachnoid hemorrhage.Brain Pathology.2017January; 27(1):51-63.PubMed(IF 5.564).

33. Bai Xuemei, Liu Song, Yuan Lin, XieYunka, Li Tong, WangLingxiao, WangXueer, ZhangTiantian, QinShucun, SongGuohau, Ge L*,Wang Zhen*（王贞）.Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice.Brain Research. 2016September 1; 1646:410-7.PubMed(IF 2.750).

34. Zhang Qun, Liu Song, Li Tong, Yuan Lin, Liu Hansen, Wang Xueer, Wang Fuwu, Wang Shuanglian, Hao Aijun, Liu Dexiang*,Wang Zhen*（王贞）. Preconditioning of bone marrow mesenchymal stem cells with hydrogen sulfide improves their therapeutic potential.Oncotarget.2016 September 6; 7(36):58089-58104.PubMed(IF 5.312).

35. Yuan Lin, Liu Song, Bai Xuemei, Gao Yan, Liu Guangheng, Wang Xueer, Liu Dexiang, Li Tong, Hao Aijun,Wang Zhen*（王贞）.Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice.Journal of Neuroinflammation. 2016 April 13; 13(1):77.PubMed(IF 5.717).

36. Zhang Qun^#, Yuan Lin^#, Zhang Qingrui, Gao Yan, LiuGuangheng, Xiu Meng, Wei Xiang,Wang Zhen*（王贞）, Liu Dexiang*.Resveratrol attenuates hypoxia-induced neurotoxicity through inhibiting microglial activation. International Immunopharmacology. 2015 July 27; 28(1):578-587.PubMed(IF 2.752).

37. Zhang Qun, Yuan Lin, Liu Dexiang, Wang Jianmei, Wang Shuanglin, Zhang Qingrui, Gong Yanfeng, Liu Hongdao, Hao Aijun,Wang Zhen*（王贞）.Hydrogen sulfide attenuates hypoxia-induced neurotoxicity through inhibiting microglial activation.Pharmacological Research. 2014 June; 84:32-44.PubMed(IF 4.409).

38.Liu Dexiang,Xie Kai,Yang Xudong,Gu Jianhua,Ge Li,Wang Xueer,Wang Zhen*（王贞）.Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in rats. Behavioural Brain Research.2014 May 1; 264:9-16.PubMed(IF 3.298).

39.Liu Dexiang,Zhang Qingrui,Gu Jianhua,Wang Xueer,Xie Kai,Xian Xiuying,Wang Jianmei,Jiang Hong,Wang Zhen*（王贞）.Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats.Progress in Neuro-Psychopharmacology and Biological Psychiatry.2014 March 3; 49:21-9.PubMed(IF 3.797).

【第一作者论文】:

1.Wang Zhen（王贞）,Zhang Qun,Yuan Lin, Wang Shuanglian,Liu Liwei,Yang Xudong,Li Ge*, Liu Dexiang*.The effects of curcumin on depressive-like behavior in mice after lipopolysaccharide administration.Behavioural Brain Research. 2014 November 1; 274:282-90.PubMed(IF 3.298).

2.Wang Zhen（王贞）,Liu Dexiang,Zhang Qun,Wang Jianmei,Zhan Jingmin, Xian Xiuying, Du Zhaoxia, Wang Xueer,Hao Aijun*.Palmitic acid affects proliferation and differentiation of neural stem cellsin vitro.Journal of Neuroscience Research, 2014 May; 92(5):574-86.PubMed(IF 2.772).

3. Jiang Hong^#,Wang Zhen^#（王贞）, Wang Yihe, Xie Kai, Zhang Qingrui, Luan Qinsong, Chen Wenqiang, Liu Dexiang*. Antidepressant-like effects of curcumin in chronic mild stress of rats: Involvement of its anti-inflammatory action.Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2013 December 2; 47:33-9PubMed(IF 3.819).

4.Wang Zhen（王贞）, Liu Dexiang, Zhan Jingmin, Xie Kai, Wang Xueer, Xian Xiuying, Gu Jianhua, Chen Wenqiang, Hao Aijun*. Melatonin improves short and long-term neurobehavioral deficits and attenuates hippocampal impairments after hypoxia in neonatal mice. Pharmacological Research. 2013 Octorber; 76:84-97.PubMed(IF 4.483).

5.Wang Zhen（王贞）, Liu Dexiang, Wang Fuwu, Zhang Qun, Du Zhaoxia, Zhan Jingmin, Yuan Qiuhuan, Ling Eng-Ang, Hao Aijun*.L-cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/H₂S pathway.Neuroscience.2013 May 1,237:106-117.PubMed(IF 3.458).

6.Wang Zhen（王贞）, Zhan Jingmin, Wang Xueer, Gu Jianhua, Xie Kai, Zhang Qingrui, Liu Dexiang*. Sodium hydrosulfide preventshypoxia-induced behavioral impairment in neonatal mice. Brain Research. 2013 November13; 1538:126-34.PubMed(IF 2.957).

7.Wang Zhen（王贞）,Gu Jianhua,Wang Xueer,Xie Kai,Luan Qingsong,WanNianqing,Zhang Qun,Jiang Hong,Liu Dexiang*.Antidepressant-like activity of resveratrol treatment in the forced swim test and tail suspension test in mice: the HPA axis, BDNF expression and phosphorylation of ERK. Pharmacology Biochemistry and Behavior. 2013 November 1; 112:104-10.PubMed(IF 2.772).

8.Wang Zhen^#（王贞）,Liu Dexiang^#, Wang Fuwu, Liu Shangming, Zhao Shidou, Ling Eng-Ang, Hao Aijun*.Saturated fatty acids activate microglia via Toll-like receptor 4/nuclear factor κB signaling. British journal of nutrition. 2012 January 28; 107(2):229-41.PubMed(IF 3.596).

9. Cai Lei^#,Wang Zhen^#（王贞）, Ji Ailing, Meyer Jason M, van der Westhuyzen Deneys R*. Scavenger receptor CD36 expression contributes to adipose tissue inflammation and cell death in diet-induced obesity. Plos one. 2012 May 16;7 (5): e36785.PubMed(IF 4.244).

10.Wang Zhen（王贞）,Liu Dexiang, Wang Juntao, Liu Shangming, Gao Ming, Ling Eng-Ang, Hao Aijun*.Cytoprotective effects of melatonin on astroglial cells subjected to palmitic acid treatment in vitro.Journal of pineal research.2012 Mar;52(2):253-64PubMed(IF 5.451).

11.Liu Dexiang^#,Wang Zhen^#（王贞）,Liu Shangming,Wang Fuwu,Zhao Shidou,Hao Aijun*. Anti-inflammatory effects of fluoxetine in lipopolysaccharide (LPS)-stimulated microglial cells.Neuropharmacology.2011 September; 61(4):592-9.PubMed(IF 3.901).

【国家授权发明专利】

1.骨桥蛋白在缺氧缺血性脑损伤中的应用

专利号：ZL 2019 1 1214238. 3

授权公告号：CN 110777201 B

2.硫化氢修饰的间充质干细胞外囊泡作为miRNA递送载体在缺氧缺血性脑病损伤中的应用

专利号ZL2019 1 1107525.4

授权公告号：CN 110772483 B

3.用于早期检测动脉瘤性蛛网膜下腔出血严重程度及预后评估的生物标志物及其应用

专利号ZL2019 1 1056539.8

授权公告号：CN 110734956 B

4.间充质干细胞来源的细胞外囊泡在治疗蛛网膜下腔出血中的应用

专利号ZL2019 1 1101638.3

授权公告号：CN 110755450 B

5.间充质干细胞来源的细胞外囊泡在脑缺血再灌注损伤中的应用

专利号：ZL 2020 1 0098965. 4

授权公告号：CN 111297898 B