学习与工作经历：

1994.9-1999.7  原山东医科大学   口腔医学            学士

2001.9-2004.7     山东大学    口腔临床医学            硕士

2004.9-2007.7      山东大学    口腔临床医学            博士

2007.8—2010.11  首都医科大学附属北京口腔医院        博士后

2010.12—2017.2     山东大学口腔医院          副主任医师/副教授

2017.03-至今         山东大学口腔医院            主任医师/教授

研究方向：

正畸牙齿移动骨改建

干细胞与牙齿及相关组织再生

学术/社会兼职：

2023.12-2026.12 中华口腔医学会口腔生物医学专业委员会    常委

2020.09-2023.09 中华口腔医学会口腔正畸专业委员会        常委

2018.11-2021.11 山东省研究型医院协会杰出青年学者分会  副主任委员

2023.05-2026.05 山东省医学会再生医学分会              副主任委员

2023.11-2026.11 山东省医院协会口腔医院分会              副主委

获奖荣誉：

2018 山东省医学科技奖 二等奖（第一位）

2019 山东省科技进步奖 二等奖（第一位）

本科生课程：

口腔生物学，口腔正畸学，骨生物学，口腔正畸学实验，口腔创新能力培养

研究生课程：

口腔生物力学，当代口腔正畸学（英文），骨生物学

1.人工智能辅助口腔正畸治疗及评估研究, 山东大学集成攻关培育项目（Integrated Research and Cultivation Project of Shandong University），No. 2022JC017，2022/07-2024/06，主持，第一立项人

2.神经血管化的牙周膜干细胞膜片实现牙周组织再生的作用及其机制研究，国家自然基金面上项目（National Natural Science Foundation of China，NSFC），No. 82071080，2021/01/01-2014/12/31，56万，主持，第一立项人

3.CircPRKD3调控机械力下牙周膜干细胞成骨分化及牙周组织改建的研究，国家自然基金面上项目（National Natural Science Foundation of China，NSFC），No. 81771030，2018/01/01-2021/12/31，56万，主持，第一立项人

4.长链非编码RNA TUG1调控牙周膜干细胞成骨分化及组织再生的研究，国家自然基金面上项目（National Natural Science Foundation of China，NSFC），No. 81470709，2015/01/01-2018/12/31，73万，主持，第一立项人

5.miR-21调控牙周膜干细胞成骨分化及组织再生的研究（National Natural Science Foundation of China，NSFC），No. 81200758，2013/01/01-2015/12-31，25万，主持，第一立项人

6.山东省泰山学者青年专家项目（Construction Engineering Special Fund of “Taishan Scholars”），No. tsqn201611068，2017/01/01-2021/12/31，主持

1. Cui S, Zhang Z, Cheng C, Tang S, Zhai M, Li L, Wei, F*, Ding G. Small Extracellular Vesicles from Periodontal Ligament Stem Cells Primed by Lipopolysaccharide Regulate Macrophage M1 Polarization via miR-433-3p Targeting TLR2/TLR4/NF-κB. Inflammation 2023, 46 (5): 1849-1858.

2. Liu B, Wang B, Wang Z, Meng Y, Li Y, Li L, Wang J, Zhai M, Liu R, Wei F*. Near-Infrared Light-Controlled MicroRNA-21-Loaded Upconversion Nanoparticles to Promote Bone Formation in the Midpalatal Suture. ACS applied materials & interfaces 2023, 15 (37): 43503-43514.

3. Zhang Z, Cui S, Fu Y, Wang J, Liu J, Wei F*. Mechanical force induces mitophagy-mediated anaerobic oxidation in periodontal ligament stem cells. Cellular & molecular biology letters 2023, 28 (1): 57.

4. Li Y, Zhao D, Wang Z, Meng Y, Liu B, Li L, Liu R, Dong S, Wei F*. Minimally invasive bone augmentation through subperiosteal injectable hydroxylapatite/laponite/alginate nanocomposite hydrogels. International journal of biological macromolecules 2023, 231, 123232.

5. Meng Y, Zhao D, Yang X, Li Y, Liu B, Zhang Z, Cui S, Wei F*. Near-Infrared Ratiometric Hemicyanine-Based pH Fluorescence Probe with Bone Targetability for Monitoring Bone Resorption. Analytical chemistry 2023, 95 (7): 3736-3745.

6. Wang J, Yang H, Ma X, Liu J, Li L, Chen L, Wei, F*. LRP6/filamentous-actin signaling facilitates osteogenic commitment in mechanically induced periodontal ligament stem cells. Cellular & molecular biology letters 2023, 28 (1): 7.

7. Zhai M, Cui S, Li L, Cheng C, Zhang Z, Liu J, Wei F*. Mechanical Force Modulates Alveolar Bone Marrow Mesenchymal Cells Characteristics for Bone Remodeling during Orthodontic Tooth Movement through Lactate Production. Cells 2022, 11 (23).

8. Zhang Z, He Q, Yang S, Zhao X, Li X, Wei F*. Mechanical force-sensitive lncRNA SNHG8 inhibits osteogenic differentiation by regulating EZH2 in hPDLSCs. Cellular signalling 2022, 93: 110285.

9. Liu J, Wang H, Zhang L, Li X, Ding X, Ding G, Wei F*. Periodontal ligament stem cells promote polarization of M2 macrophages. Journal of leukocyte biology 2022.

10. Wang M, Zhang B, Li L, Zhai M, Wang Z, Wei F*. Vertical stability of different orthognathic treatments for correcting skeletal anterior open bite: a systematic review and meta-analysis. European journal of orthodontics 2022, 44(1): 1-10.

11. Gu X, Li X, Jin Y, Zhang Z, Li M, Liu D, Wei F*. CDR1as regulated by hnRNPM maintains stemness of periodontal ligament stem cells via miR-7/KLF4. Journal of cellular and molecular medicine 2021, 25(9): 4501-4515.

12. Wang H, Feng C, Li M, Zhang Z, Liu J, Wei F*. Analysis of lncRNAs-miRNAs-mRNAs networks in periodontal ligament stem cells under mechanical force. Oral diseases 2020.

13. Wang H, Li X, Zhang Z, Zhao X, Wang C, Wei F*. MicroRNA-21 promotes bone reconstruction in maxillary bone defects. Journal of oral rehabilitation 2020, 47 Suppl 1: 4-11.

14. Li X, Zhang B, Wang H, Zhao X, Zhang Z, Ding G, Wei F*. The effect of aging on the biological and immunological characteristics of periodontal ligament stem cells. Stem cell research & therapy 2020, 11(1): 326.

15. Yang S, Hu L, Wang C, Wei F*. PERK-eIF2α-ATF4 signaling contributes to osteogenic differentiation of periodontal ligament stem cells. Journal of molecular histology 2020, 51(2): 125-135.

16. Li M, Zhang Z, Gu X, Jin Y, Feng C, Yang S, Wei F*. MicroRNA-21 affects mechanical force-induced midpalatal suture remodelling. Cell proliferation 2020, 53(1): e12697.

17. Wang H, Feng C, Jin Y, Tan W, Wei F*. Identification and characterization of circular RNAs involved in mechanical force-induced periodontal ligament stem cells. Journal of cellular physiology 2019, 234(7): 10166-10177.

18. Wang H, Feng C, Wang M, Yang S, Wei F*. Circular RNAs: Diversity of Functions and a Regulatory Nova in Oral Medicine: A Pilot Review. Cell transplantation 2019, 28(7): 819-830.

19. He Q, Yang S, Gu X, Li M, Wang C, Wei F*. Long noncoding RNA TUG1 facilitates osteogenic differentiation of periodontal ligament stem cells via interacting with Lin28A. Cell death & disease 2018, 9(5): 455.

20. Gu X, Li M, Jin Y, Liu D, Wei F*. Identification and integrated analysis of differentially expressed lncRNAs and circRNAs reveal the potential ceRNA networks during PDLSC osteogenic differentiation. BMC genetics 2017, 18(1): 100.

21. Li M, Feng C, Gu X, He Q, Wei F*. Effect of cryopreservation on proliferation and differentiation of periodontal ligament stem cell sheets. Stem cell research & therapy 2017, 8(1): 77.

22. Wei F, Qu C, Song T, Ding G, Fan Z, Liu D, Liu Y, Zhang C, Shi S, Wang S. Vitamin C treatment promotes mesenchymal stem cell sheet formation and tissue regeneration by elevating telomerase activity. Journal of cellular physiology 2012, 227, (9), 3216-24.