学习与工作经历：

2023.07至今，山东大学 研究员，临床副教授

2020.01至今，山东大学附属生殖医院，副主任医师

2018.01-2019.12，山东大学附属生殖医院，主治医师

2017.10-2017.12，山东大学附属生殖医院，住院医师 

2016.01-2017.01，香港中文大学，访问学者

2015.10-2017.10，上海交通大学，博士后

2012.09-2015.06，山东大学，医学院，博士

2009.09-2012.06，山东大学，医学院，硕士

2004.09-2009.06，潍坊医学院，临床医学，学士

研究方向：

早发性卵巢功能不全（POI）的遗传学致病机制研究

学术/社会兼职：

妇幼健康研究会生殖内分泌学专业委员会 委员

山东省医师协会妇产科医师分会 委员兼秘书

获奖荣誉：

2022年山东省医学会青年科技一等奖

本科生课程：

妇产科学

生殖医学研究锦囊-从基础到临床

研究生课程：

（1）2022YFC2703000，生殖细胞与性腺组织冻融关键机理研究及功能修复新技术研发应用，国家重点研发计划，2022.12-2025.11，67万元，子课题负责人

（2）2018YFC1003700，原始卵泡库的形成、维持与激活，国家重点研发计划，2018.12-2021.12，195万元，课题骨干

（3）32070847，DNA同源重组基因EXO1和BRCA2在早发性卵巢功能不全发病中的作用和致病机制研究，国家自然科学基金面上项目，2021.01-2024.12，58万元，项目负责人

（4）31601198，DNA损伤修复基因MSH5在卵巢早衰发病中的作用和机制研究，国家自然科学基金青年项目，2017.01-2019.12，20万，项目负责人

（5）ZR2022YQ69，减数分裂起始相关基因在早发性卵巢功能不全中的作用及致病机制研究，山东省优秀青年基金，2023.01 -2025.12，50万元，项目负责人

（6）tsqn202211371，早发性卵巢功能不全的遗传学致病机制研究，泰山学者青年计划，2022.7-2025.07，37.5万元，课题负责人

1.Ke Hanni^#, Tang Shuyan^#,Guo Ting^#, Hou Dong, Jiao Xue, Li Shan, Luo Wei, Xu Bingying, Zhao Shidou, Li Guangyu, Zhang Xiaoxi, Xu Shuhua, Wang Lingbo, Wu Yanhua, Wang Jiucun, Zhang Feng*,Qin Yingying*, Jin Li*, Chen Zi-Jiang*.Landscape of pathogenic mutations in premature ovarian insufficiency.Nature Medicine.2023, 29(2):483-492.

2.Xu Bingying, Li Zhuqing, Li Shan, Ke Hanni, Zhang Qian, Qin Yingying,Guo Ting*. Pathogenic variants in TSC2 might cause premature ovarian insufficiency through activated mTOR induced hyperactivation of primordial follicles.Fertility and Sterility.2022, 118(6):1139-1149.

3.Hou Dong, Yao Chencheng, Xu Bingying, Luo Wei, Ke Hanni, Li Zheng, Qin Yingying,Guo Ting*. Variations of C14ORF39 and SYCE1 identified in idiopathic premature ovarian insufficiency and nonobstructive azoospermia.Journal of Clinical Endocrinology & Metabolism.2022, 107(3):724-734.

4.Li Shan, Xu Weiwei, Xu Bingying, Gao Shuchang., Zhang Qian, Qin Yingying,Guo Ting*. Pathogenic variations of homologous recombination gene HSF2BP identified in sporadic patients with premature ovarian insufficiency,Frontiers in Cell and Developmental Biology.2022;9:768123.

5.Zhang Qian, Tao Chengqiu, Gao Shuchang, Li Shan, Xu Bingying, Ke Hanni, Wang Yiyang, Zhang Feng, Qin Yingying, Zhang Ling*,Guo Ting*. Homozygous variant in KASH5 causes premature ovarian insufficiency by disordered meiotic homologous pairing.Journal of Clinical Endocrinology & Metabolism.2022, 107(9):2589-2597.

6.Zhao Simin, Huang Chengzi, Yang Yajuan, Xu Weiwei, Yu Yongze, Wen Canxin, Cao Lili, Gao Fei, Qin Yingying, Chen Zi-Jiang,Guo Ting*, Zhao Shidou*. DNA repair protein FANCD2 has both ubiquitination-dependent and -independent functions during germ cell development.Journal of Biological Chemistry.2023, 299(3):102905.

7.Yao Chencheng, Hou Dong, Ji Zhiyong, Pang Dongmei, Li Peng, Tian Ruhui, Zhang Yuxiang, Ou Ningjing, Bai Haowei, Zhi Erlei, Huang Yuhua, Qin Yingying, Zhao Jingpeng, Wang Chenchen, Zhou Zhi,Guo Ting*, Li Zheng*. Bi-allelic SPATA22 variants cause premature ovarian insufficiency and nonobstructive azoospermia due to meiotic arrest.Clinical Genetics.2022, 101(5-6):507-516.

8.Luo Wei, Ke Hanni, Tang Shuyan, Jiao Xue, Li Zhuqing, Zhao Shidou, Zhang Feng,Guo Ting*, Yingying Qin*. Next-generation sequencing of 500 POI patients identified novel responsible monogenic and oligogenic variants.Journal of Ovarian Research. 2023, 16(1):39.

9.Huang Chengzi,Guo Ting*, Qin Yingying*. Meiotic recombination defects and premature ovarian insufficiency.Frontiers in Cell and Developmental Biology. 2021, 9:652407.

10.Jiao Wenlin, Zhao Shidou, Liu Ran,Guo Ting*, Qin Yingying*. CPEB1 deletion is not a common explanation for premature ovarian insufficiency in a Chinese cohort.Journal of Ovarian Research.2020, 13:49.

11.Guo Ting, Zhao Shidou, Zhao Shigang, Chen Min, Li Guangyu, Jiao Xue, Wang Zhao, Zhao Yueran, Qin Yingying*, Gao Fei*, Chen Zi-Jiang*. Mutations in MSH5 in primary ovarian insufficiency,Human Molecular Genetics.2017, 26(8): 1452-1457.

12.Wang Yiyang^#,Guo Ting^#, Ke Hanni, Zhang Qian, Li Shan, Luo Wei, Qin Yingying*. Pathogenic variants of meiotic double strand break (DSB) formation genes PRDM9 and ANKRD31 in premature ovarian insufficiency.Genetics in Medicine.2021, 23(12):2309-2315.

13.Qin Yingying^#,Guo Ting^#, Li Guangyu, Tang Tieshan, Zhao Shidou, Jiao Xue, Gong Juanjuan, Gao Fei, Guo Caixia, Simpson Joe Leigh, Chen Zi-Jiang*. CSB-PGBD3 Mutations Cause Premature Ovarian Failure.PLoS Genetics.2015, 11: e1005419.

14.Guo Ting^#,Zheng Ye^#, Li Guangyu, Zhao Shidou, Ma Jinlong, Qin Yingying*. Novel pathogenic mutations in minichromosome maintenance complex component 9 (MCM9) responsible for premature ovarian insufficiency.Fertility and Sterility.2020, 113(4): 845-852.

15.Luo Wei^#,Guo Ting^#, Li Guangyu, Liu Ran, Zhao Shidou, Song Meihui, Zhang Liangran, Wang Shunxin, Chen Zi-Jiang, Qin Yingying*. Variants in homologous recombination genes EXO1 and RAD51 related with premature ovarian insufficiency.Journal of Clinical Endocrinology & Metabolism.2020, 105(10), e3566–e3574.

16.Liu Hongli^#,Guo Ting^#, Gong Zheng, Yu Yongze, Zhang Yingxin, Zhao Shidou*, Qin Yingying*. Novel FSHR mutations in Han Chinese women with sporadic premature ovarian insufficiency.Molecular and Cellular Endocrinology. 2019, (492): 110446.

17.Dou Xiaoyun^#,Guo Ting^#, Li Guangyu, Zhou LiGuang, Qin Yingying*, Chen Zi-Jiang. Minichromosome maintenance complex component 8 mutations cause primary ovarian insufficiency.Fertility and Sterility.2016;106 (6):1485-1489.