学习经历：

2001.09-2006.06，第三军医大学，医学检验，学士

2008.09-2013.06，第三军医大学，临床检验诊断学（硕博连读），博士

2015.01-2017.11，济南军区总医院，临床医学，博士后

工作经历：

2006.07-2008.08，济南军区第88医院，技师

2013.07-2020.08，解放军第960医院，主管技师

2020.09-2022.03，济南市中心医院，主任技师 

2022.04-至今，山东省第二人民医院（山东省耳鼻喉医院、山东省耳鼻喉研究所），科研处兼临床检验中心，主任/主任技师

研究方向：

炎症相关疾病分子调控机制及靶向治疗策略研究，目前聚焦内耳免疫

学术/社会兼职：

中国遗传学会女科学家分会委员；中国抗癌协会肿瘤临床检验与伴随诊断专业委员会委员；中国医学装备协会应急救治装备分会常务委员；山东省医学会临床检验学分会委员、青年学组副组长等。

获奖荣誉：

山东省泰山学者青年专家（2024）

中国生物物理学会第二届女科学家优秀科研成果二等奖（2023）

本科生课程：

研究生课程：

1.82371154，前庭巨噬细胞cGAS-STING通路活化介导免疫微环境失衡在梅尼埃病中的作用及机制研究，国家自然科学基金面上项目，2024/01-2027/12，49万元，主持。

2.81501721，外体miR-25靶向KLF2/4介导内皮细胞炎症损伤在幽门螺杆菌感染诱发冠心病中的作用机制研究，国家自然科学基金青年项目，2016/01-2018/12，18万元，主持。

3.ZR2021MH385，巨噬细胞脂噬受抑致焦亡发生在幽门螺杆菌促动脉粥样硬化中的机制研究，山东省自然科学基金面上项目，2022/01-2024/12，10万元，主持。

4.YXH2024QS052，D-二聚体和FDP检测试剂的抗干扰能力评估，山东省医学会一般项目（青年项目），2024/12-2026/12，10万元，主持。

5.202307010258，基于Olink靶向蛋白质组学技术探究梅尼埃病患者血浆生物标志物，山东省医药卫生科技项目重点项目，2024/01-2025/12，10万元，主持。

1.Na Zhang #, Yongdong Song #, Hanyue Wang, Xiaofei Li, Yafeng Lyu, Jiahui Liu, Yurong Mu, Yan Wang, Yao Lu, Guorong Li, Zhaomin Fan, Haibo Wang*, Daogong Zhang*,Na Li*. IL-1β promotes glutamate excitotoxicity: indications for the link between inflammatory and synaptic vesicle cycle in Ménière's disease. Cell Death Discovery. 2024 Nov 20;10(1):476. (*通讯作者)

2.Shuai Leng, Haijie Li, Pengfei Zhang, Zhiqiao Dang, Baowei Shao, Shishan Xue, Yansong Ning, Xilong Teng, Leilei Zhang, Honglu Wang,Na Li*, Fengquan Zhang*, Wenqian Yu*. SGK1-Mediated Vascular Smooth Muscle Cell Phenotypic Transformation Promotes Thoracic Aortic Dissection Progression. Arteriosclerosis Thrombosis And Vascular Biology. 2024 Dec 5. (*通讯作者)

3.Wenqian Yu, Xiaona Lin, Shuai Leng, Yiming Hou, Zhiqiao Dang, Shishan Xue,Na Li*, Fengquan Zhang*. The PRC2 complex epigenetically silences GATA4 to suppress cellular senescence and promote the progression of breast cancer. Translational oncology. 2024 Aug;46:102014. (*通讯作者)

4.Wandi Xu, Xiaofei Li, Yongdong Song, Ligang Kong, Na Zhang, Jiahui Liu, Guorong Li, Zhaomin Fan, Yafeng Lyu, Daogong Zhang, Haibo Wang, Na Li*. Ménière's disease and allergy: Epidemiology, pathogenesis, and therapy. Clinical And Experimental Medicine. 2023 Nov;23(7):3361-3371. (*通讯作者)

5.Yiming Hou#, Wenqian Yu#, Gaoyi Wu, Zhaoling Wang, Shuai Leng, Ming Dong,Na Li*, Lei Chen*. Carcinogenesis promotion in oral squamous cell carcinoma: KDM4A complex-mediated gene transcriptional suppression by LEF1. Cell Death & Disease. 2023 Aug 8;14(8):510. (*通讯作者)

6.Daogong Zhang; Wenqian Yu; Jiahui Liu; Ligang Kong; Na Zhang; Yongdong Song; Xiaofei Li; Zhaomin Fan; Yafeng Lyu;Na Li*; Haibo Wang* ; Serum/glucocorticoid-inducible kinase 1 deficiency induces NLRP3 inflammasome activation and autoinflammation of macrophages in a murine endolymphatic hydrops model, Nature communications, 2023, 14(1): 1249. (*通讯作者)

7.Na Zhang#,Na Li#, Siyue Wang, Wandi Xu, Jiahui Liu, Yafeng Lyu, Xiaofei Li, Yongdong Song, Ligang Kong, Yalan Liu, Jia Guo, Zhaomin Fan, Daogong Zhang*, Haibo Wang*. Protective effect of anakinra on audiovestibular function in a murine model of endolymphatic hydrops, Frontiers in Cellular Neuroscience, 2022 Dec 15;16:1088099. ( #共同第一作者)

8.Na Zhang, Yafeng Lyu, Jia Guo, Jiahui Liu, Yongdong Song, Zhaomin Fan, Xiaofei Li,Na Li*, Daogong Zhang*, Haibo Wang*. Bidirectional Transport of IgE by CD23 in the Inner Ear of Patients with Meniere's Disease, Journal of Immunology, 2022, 208(4): 827-838. (*通讯作者)

9.Wenqian Yu, Baowei Shao, Meng Li, Pengfei Zhang, Haijie Li, Xilong Teng, Honglu Wang, Fengquan Zhang, andNa Li *. Influence of sex and menopausal status on the relationship between metabolic syndrome and coronary artery calcification: a Chinese community-based cross-sectional study, Menopause, 2021 Feb 22;28(5):546-553. (*通讯作者)

10.Na Li, Shi-feng Liu, Kai Dong, Gui-chun Zhang, Jing Huang, Zhi-heng Wang，Tong-jian Wang. Exosome-transmitted miR-25 induced by H. pylori promotes vascular endothelial cell injury by targeting KLF2, Front Cell Infect Microbiol, 2019 Oct 29,9:366.

11.Na Li, Jianlong Wang, Wenqian Yu, Kai Dong, Feng You, Biao Si, Bin Tang, Yan Zhang, Tongjian Wang*, Bin Qiao*. MicroRNA-146a negatively modulates the interleukin-17A induced inflammatory responses during Helicobacter pylori infection, Mol Med Rep, 2019 Feb;19(2):1388-1395. (IF=2.100)

12.Na Li, Bin Tang, Yin-ping Jia, Pan Zhu, Yuan Zhuang, Yao Fang, Qian Li, Kun Wang, Weijun Zhang, Gang Guo, Tong-jian Wang, You-jun Feng, Bin Qiao*, Quanming Zou*, Xuhu Mao*, Helicobacter pylori CagA protein negatively regulates autophagy and promotes inflammatory response via c-Met-PI3K/Akt-mTOR signaling pathway, Front Cell Infect Microbiol, 2017, 7: 417. (IF=4.300)

13.Na Li, Biao Si, Ji-Feng Ju, Meng Zhu, Feng You, DongWang, Jie Ren, Yan-Song Ning, Feng-Quan Zhang, Kai Dong, Jing Huang, Wen-Qian Yu, Tong-Jian Wang*, Bin Qiao*, Nicotine induces cardiomyocyte hypertrophy through TRPC3-mediated Ca2+/ NFAT signaling pathway, Canadian Journal of Cardiology, 2016 Oct;32(10):1260. (IF=5.592)

14.Tang B#,Li N#, Gu J, Zhuang Y, Li Q, Wang HG, Fang Y, Yu B, Zhang JY, Xie QH, Chen L, Jiang XJ, Xiao B, Zou QM*, Mao XH*, Compromised autophagy by MIR30B benefits the intracellular survival of Helicobacter pylori, Autophagy, 2012 Jul 1, 8(7):1045-57. ( #共同第一作者)

15.Li N#, Xu X#, Xiao B*, Zhu ED, Li BS, Liu Z, Tang B, Zou QM, Liang HP*, Mao XH*, H. pylori related proinflammatory cytokines contribute to the induction of miR-146a in human gastric epithelial cells, Mol Biol Rep, 2012 Apr, 39(4):4655-61.

16.Li N, Tang B, Zhu ED, Li BS, Zhuang Y, Yu S, Lu DS, Zou QM, Xiao B*, Mao XH*, Increased miR-222 in H. pylori-associated gastric cancer correlated with tumor progression by promoting cancer cell proliferation and targeting RECK, FEBS Lett, 2012 Mar 23, 586(6):722-8.