学习与工作经历：

1986-09 ~ 1991-07，泰山医学院，学士

1998-12 ~ 2001-12，山东大学，硕士

2003-09 ~ 2006-07，解放军军医进修学院，博士

1991-10 ~ 2007-05，济南市第二人民医院，眼一科主任

2007-05 ~ 2021-01，山东大学第二医院，眼科主任

2021.02至今，山东省立医院，眼科主任

研究方向：

白内障、眼底病等各类眼科疾病的分子生物学基础

学术/社会兼职：

中华医学会眼科分会委员、中华医学会白内障学组委员、中国老年医学会白内障工作委员会副主委、康复医学会视力康复委员会常委、中国中西医结合学会眼科分会委员、中国医师协会眼科分会委员、山东省康复医学会视力康复委员会主任委员、山东省医学会眼科分会副主任委员、山东医师协会眼科分会副主任委员、山东中西医结合学会眼科分会副主任委员、《中华眼科杂志》通讯编委、《山东大学耳鼻喉眼学报》杂志副主编。

获奖荣誉：

本科生课程：

眼科学

研究生课程：

81873677；糖尿病白内障中Mcl-1调控线粒体凋亡及G2/M周期阻滞的分子机制及功能研究；国家级自然科学基金面上项目；2019.01-2022.12；56万元；项目负责人

1. Zhang, Q., Q. Zhang, H. Li, X. Zhao, and H. Zhang, LiCl induces apoptosis via CHOP/NOXA/Mcl-1 axis in human choroidal melanoma cells. Cancer Cell Int, 2021. 21(1): p. 96.

2. Li, H., X. Wang, X. Zhao, G. Li, F. Pei, H. Zhang, Y. Tan, and F. Chen, Vacancy-Induced Antibacterial Activity of XS2- y Quantum Dots against Drug-Resistant Bacteria for Treatment of Bacterial Keratitis. Small, 2020. 16(42): p. e2004677.

3. Wei, C., X. Zhao, L. Wang, and H. Zhang, TRIP suppresses cell proliferation and invasion in choroidal melanoma via promoting the proteasomal degradation of Twist1. FEBS Lett, 2020. 594(19): p. 3170-3181.

4. Wang, J., X. Gao, J. Liu, J. Wang, Y. Zhang, T. Zhang, and H. Zhang, Effect of intravitreal conbercept treatment on the expression of Long Noncoding RNAs and mRNAs in Proliferative Diabetic Retinopathy Patients. Acta Ophthalmol, 2019. 97(6): p. e902-e912.

5. Li, X., H. Song, F. Kong, Y. Guo, Y. Chen, L. Zhang, D. Gao, X. Zhao, and H. Zhang, Pemetrexed exerts anticancer effects by inducing G0/G1-phase cell cycle arrest and activating the NOXA/Mcl-1 axis in human esophageal squamous cell carcinoma cells. Oncol Lett, 2019. 17(2): p. 1851-1858.

6. Wang, Jiawei; Liu, Yaoming; Zhao, Xiaofei; Zhang, Han , Gastrodin protects retinal ganglion cells through inhibiting microglial-mediated neuroinflammation in an acute ocular hypertension model , INTERNATIONAL JOURNAL OF OPHTHALMOLOGY, 2017.10.18, 10(10): 1483~1489

7. Song, Wei; Zhao, Xiaofei; Xu, Jiarui; Zhang, Han, Quercetin inhibits angiogenesis-mediated human retinoblastoma growth by targeting vascular endothelial growth factor receptor, ONCOLOGY LETTERS, 2017.9, 14(3): 3343~3348

8. Zhao, Xiaofei; Kong, Feng; Wang, Lei; Zhang, Han, c-FLIP and the NOXA/Mcl-1 axis participate in the synergistic effect of pemetrexed plus cisplatin in human choroidal melanoma cells , PLOS ONE, 2017.9.1, 12(9)

9. Yang, Lixia; Xiao, Juan; Wang, Jiawei; Zhang, Han, Clinical Characteristics and Risk Factors of Recurrent Mooren's Ulcer , JOURNAL OF OPHTHALMOLOGY, 2017.6, 2017

10. Zhang, Han ; Zhao, Jun; Zhang, Lijun; Liu, Jing; Liu, Yuan; Song, Wei; Tian, Qingfen; Wang, Qi; Hamilton, David-Rex , Comparison of iris-fixated foldable lens and scleral-fixated foldable lens implantation in eyes with insufficient capsular support , INTERNATIONAL JOURNAL OF OPHTHALMOLOGY, 2016.1 1.18, 9(11): 1608~1613

11. Zhao, Jun; Li, Zhaohui ; Wang, Lei; Liu, Jing; Wang, Dajiang; Chen, Guoling; Wang, Qi; Zhang, Han , Foxp3-expressing sensitized Teff cells prolong survival of corneal allograft in corneal allograft transplantation mouse model , Transplant Immunology, 2015.11, 33(3): 192~197

12. GL Chen, JJ Zhang, H Zhang, Y Xiao, X Kao, Yl Liu, ZY Liu. Anti- inflammatory effect of emodin on lipopolysaccharide-induced keratitis in Wistar rats. Int J Clin Exp Med. 2015;8(8): 12382-12389.

13. Chen, Guoling; Zhang, Jingjing; Zhao, Jun; Wang, Dajiang; Zhang, Han, Evaluation of corneal graft survival in mice model , International Journal of Ophthalmology, 2013, 6(5): 578~583