学习与工作经历：

2022/10至今，山东大学，药物化学研究所，教授

2017/11- 2022/09，美国弗吉尼亚联邦大学，药物化学系，博士后

2012/09 - 2017/06，山东大学，药物化学专业，博士

2008/09 - 2012/06，山东大学，制药工程专业，学士

研究方向：

1.靶向阿片受体的创新药物研究（镇痛药物、抗成瘾治疗药物）

2.靶向GPCR异源二聚体的小分子探针设计、合成与功能探究

3.具有镇痛活性的天然产物发现

4.基于结构/机制的抗艾滋病药物研究

学术/社会兼职：

Pharmaceutical Science Advances杂志Scientific Editor；Pharmaceuticals、Molecules等杂志Guest Editor；担任十余个SCI期刊特邀审稿人。山东省自然科学基金会议评审专家；深圳市医学研究专项资金项目通讯评审与会议评审专家。

获奖荣誉：

国家海外高层次青年人才（2022）

本科生课程：

Inorganic Chemistry（留学生）、Inorganic Chemistry Experiments（留学生）

研究生课程：

实验室有机制备与分离技术、高等有机化学

国家海外高层次青年人才项目，抗病毒药物化学研究，2023/01-2025/12，主持

山东大学杰出中青年学者科研启动基金，2022/11-2027/10，主持

1.Huang, B.^#;Li, M.^#; Klongkumnuankarn, P.; Mendez, R.E.;Gillespie,J.C.; Stevens, D.L.; Dewey, W.L.; Selley, D.E.; Zhang, Y.* Rational Design, Chemical Syntheses, and Biological Evaluations of Peripherally Selective Mu Opioid Receptor Ligands as Potential Opioid Induced Constipation Treatment.J. Med. Chem.2022,65, 4991-5003

2.Huang, B.; Wang, H.; Zheng, Y.; Li, M.; Kang, G.; Barreto-de-Souza, V.; Nassehi, N.; Knapp, P.E.; Selley, D.E.; Hauser, K.F.; Zhang, Y.* Structure-Based Design and Development of Chemical Probes Targeting Putative MOR-CCR5 Heterodimers to Inhibit Opioid Exacerbated HIV-1 Infectivity.J. Med. Chem.2021,64, 7702–7723.

3.Huang, B.; Ginex, T.; Luque, F. J.; Jiang, X.; Gao, P.; Zhang, J.; Kang, D.; Daelemans, D.; De Clercq, E.; Pannecouque, C.; Zhan, P.*; Liu, X.* Structure-based Design and Discovery of Pyridyl-bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies.J. Med. Chem.2021,64, 13604-13621. (当期封面文章)

4.Huang, B.; Chen, W.; Zhao, T.; Li, Z.; Jiang, X.; Ginex, T.; Vílchez, D.; Luque, F. J.; Kang, D.; Gao, P.; Zhang, J.; Tian, Y.; Daelemans, D.; De Clercq, E.; Pannecouque, C.*; Zhan, P.*; Liu, X.* Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles.J. Med. Chem.2019,62, 2083-2098.

5.Huang, B.; Li, C.; Chen, W.; Liu, T.; Yu, M.; Fu, L.; Sun, Y.; Liu, H.; De Clercq, E.; Pannecouque, C.; Balzarini, J.; Zhan, P.*; Liu, X.* Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and physicochemical property-driven approaches.Eur. J. Med. Chem.2015,92, 754-765.

6.Huang, B.^#; Liang, X.^#; Li, C.; Chen, W.; Liu, T.; Li, X.; Sun, Y.; Fu, L.; Liu, H.; De Clercq, E.; Pannecouque, C.; Zhan, P.*; Liu, X.* Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 4: design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazines.Eur. J. Med. Chem.2015,93, 330-337.

7.Huang, B.;Gunta, R.; Wang, H.; Li, M.; Cao, D.; Mendez, R.E.;Gillespie,J.C.; Chen, C.; Huang, L.H.M.; Liu-Chen, L.Y.; Selley, D.E.;Zhang, Y.* Verifying the role of 3-hydroxy of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[(4′-pyridyl) carboxamido]morphinan derivatives via their binding affinity and selectivity profiles on opioid receptors.Bioorg. Chem.2021,109, 104702.

8. Henneh, I.T.^#;Huang, B.^#; Musayev, F.N.; Hashimi, R.A.; Safo, M.K.; Armah, F.A.; Ameyaw, E.O.; Adokoh, C.K.; Ekor, M.*; Zhang, Y.* Structural elucidation andin vivoanti-arthritic activity of β-amyrin and polpunonic acid isolated from the root bark of Ziziphus abyssinica HochstEx. A Rich (Rhamnaceae).Bioorg. Chem.2020,98, 103744.

9.Huang, B.;Zhang, Y.* Teaching an old dog new tricks: Drug discovery by repositioning natural products and their derivatives.Drug Discov. Today.2022,27, 1936-1944.

10.Huang, B.; St. Onge, C.; Ma, H.; Zhang, Y.* Design of bivalent ligands targeting putative GPCR dimers.Drug Discov. Today.2021,26, 189-199.