1.Shang P#, Rong N#, Jiang JJ#, Cheng J#, Zhang MH#,Kang D#, Qi L#, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y*, Li Q*, Shao ZH*, Yang F*, Sun JP*. Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.Cell. 2023 Nov 22;186(24):5347-5362.e24.
2.Dong T, Zhao F, Wang M, Lyu K, Zhu J, Zhang W, Li W, An Y, Liu N, Singh AP, Yang Y,Kang D*, Liu X*.G3BP1/2-Targeting PROTAC Disrupts Stress Granules Dependent ATF4 Migracytosis as Cancer Therapy.J Am Chem Soc. 2025 Jan 8;147(1):446-461.
3.Zhou Z, Zhang W, Zhao F, Gao N, Tao S, Wang N, Jiang JJ, Yang F*, Sun JP*, Liu X*,Kang D*. In Silico Discovery of Novel Potent Trace Amine-Associated Receptor TAAR1 Agonists as Promising Drug Candidates for the Treatment of Schizophrenia.J Med Chem.2025 May 22;68(10):10255-10267.
4.ZhouZ, Zhang W, Zhao F, Sun Y, Wang N, Cheng J, Zhan P, Yang F*, Sun JP*, Liu X*,Kang D*.Structure-Based Design of Novel G-Protein-Coupled Receptor TAAR1 Agonists as Potential Antipsychotic Drug Candidates.J Med Chem. 2024 Mar 14;67(5):4234-4249.
5.Zhao F, Zhang H, Xie M, Meng B, Liu N, Dun C, Qin Y, Gao S, De Clercq E, Pannecouque C, Tang YJ, Zhan P*, Liu X*,Kang D*. Structure-Based Optimization of 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Exploiting the Tolerant Regions of the Non-Nucleoside Reverse Transcriptase Inhibitors' Binding Pocket.J Med Chem.2023 Feb 9;66(3):2102-2115.
6.Sun Y, Zhou Z, Feng D, Jing L, Zhao F, Wang Z, Zhang T, Lin H, Song H, De Clercq E, Pannecouque C, Zhan P*, Liu X*,Kang D*. Lead Optimization and Avoidance of Metabolic-perturbing Motif Developing Novel Diarylpyrimidines as Potent HIV-1 NNRTIs.J Med Chem. 2022 Dec 8;65(23):15608-15626.
7.Kang D*, Sun Y, Feng D, Gao S, Wang Z, Jing L, Zhang T, Jiang X, Lin H, De Clercq E, Pannecouque C, Zhan P*, Liu X*. Development of Novel Dihydrofuro[3,4-d]pyrimidine Derivatives as HIV-1 NNRTIs to Overcome the Highly Resistant Mutant Strains F227L/V106A and K103N/Y181C.J Med Chem. 2022 Feb 10;65(3):2458-2470.
8.Kang D*, Ruiz FX, Sun Y, Feng D, Jing L, Wang Z, Zhang T, Gao S, Sun L, De Clercq E, Pannecouque C, Arnold E*, Zhan P*, Liu X*. 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies.J Med Chem.2021 Apr 8;64(7):4239-4256.
9.Kang D, Feng D, Tiziana G, Zou J, Wei F, Zhao T, Huang B, Sun Y, Samuel D, De Clercq E, Pannecouque C, Zhan P*, Liu X*.Exploring the hydrophobic channel of NNIBP led to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs.Acta Pharmaceutica Sinica B.2020 May;10(5):878-894.
10.Kang D, Feng D, Sun Y, Fang Z, Wei F, De Clercq E, Pannecouque C*, Liu X*, Zhan P*. Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties.J Med Chem. 2020 May 14;63(9):4837-4848.